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John Sanseverino et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(1), 122-134 (2008-11-11)
Saccharomyces cerevisiae bioluminescent bioreporter assays were developed previously to assess a chemical's estrogenic or androgenic disrupting potential. S. cerevisiae BLYES, S. cerevisiae BLYAS, S. cerevisiae BLYR, were used to assess their reproducibility and utility in screening 68, 69, and 71
X Xu et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 9(8), 781-786 (2000-08-22)
Isoflavones are soy phytoestrogens that have been suggested to be anticarcinogenic. Our previous study in premenopausal women suggested that the mechanisms by which isoflavones exert cancer-preventive effects may involve modulation of estrogen metabolism away from production of potentially carcinogenic metabolites
S E Kulling et al.
Journal of agricultural and food chemistry, 49(6), 3024-3033 (2001-06-21)
The soy isoflavones daidzein and genistein are found in high concentrations in human plasma and urine after soy consumption. However, in vitro and in vivo data regarding the oxidative metabolism of isoflavones in humans are scarce. Therefore, we have studied
Chao Wu Xiao et al.
Experimental biology and medicine (Maywood, N.J.), 239(6), 707-714 (2014-03-29)
Protein disulfide isomerase (PDI) is a multifunctional protein and plays important roles in protein folding, triglyceride transfer, insulin degradation, and thyroid hormone transportation. This study examined the modulation of PDI expression by soy consumption using rat as a model. Sprague-Dawley
Bidyadhar Das et al.
Experimental parasitology, 153, 151-159 (2015-03-31)
Pyruvate kinase (PK; EC 2.7.1.40) and phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) are essential regulatory enzymes of glucose oxidation in helminths, the PK/PEPCK branch point being the first divergent step between carbohydrate catabolism of the parasites and their hosts. Recently, PEPCK
Fang-Rong Chang et al.
Journal of natural products, 68(7), 971-973 (2005-07-26)
The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and
Lizhen Qiao et al.
Journal of chromatography. A, 1396, 62-71 (2015-04-22)
Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chromatography. The obtained columns of tricationic ionic liquids were evaluated respectively in the
Meimei Yang et al.
Journal of cardiovascular pharmacology, 66(1), 16-24 (2015-07-15)
Transient receptor potential melastatin 7 (TRPM7) is a Ca, Mg permeable nonselective cation channel of the TRP channel superfamily and plays an important role in cell growth and proliferation. Compounds that alter the activity and expression of the channel protein
Chung-Hsi Chou et al.
Food chemistry, 168, 63-69 (2014-08-31)
Black vinegar (BV) contains abundant essential and hydrophobic amino acids, and polyphenolic contents, especially catechin and chlorogenic acid via chemical analyses. K and Mg are the major minerals in BV, and Ca, Fe, Mn, and Se are also measured. After
Jutarmas Jungsukcharoen et al.
Bioscience, biotechnology, and biochemistry, 78(6), 917-926 (2014-07-19)
We investigated the major leaf isoflavonoid contents of Pueraria mirifica from three different cultivars (PM-III, PM-IV, and PM-V) using reverse RP-HPLC analysis. The proportions and net levels of puerarin, daidzin, genistin, and daidzein in P. mirifica leaves were found to
J W Lampe et al.
The American journal of clinical nutrition, 60(1), 122-128 (1994-07-01)
Lignans and isoflavonoid phytoestrogens, produced from plant precursors by colonic bacteria, may protect against certain cancers. We examined the effects of flaxseed consumption on urinary lignans and isoflavonoids. Eighteen women consumed their usual omnivorous diets for three menstrual cycles and
I R Rowland et al.
Nutrition and cancer, 36(1), 27-32 (2000-05-08)
The soy isoflavones, daidzein and genistein, and the lignans, matairesinol and secoisolariciresinol, are phytoestrogens metabolized extensively by the intestinal microflora. Considerable important evidence is already available that shows extensive interindividual variation in isoflavone metabolism, and we have investigated the extent
Oussama Ahrazem et al.
Plant science : an international journal of experimental plant biology, 234, 60-73 (2015-03-26)
Glycosyltransferases play diverse roles in cellular metabolism by modifying the activities of regulatory metabolites. Three stress-regulated UDP-glucosyltransferase-encoding genes have been isolated from the stigmas of saffron, UGT85U1, UGT85U2 and UGT85V1, which belong to the UGT85 family that includes members associated
M L de Lemos
The Annals of pharmacotherapy, 35(9), 1118-1121 (2001-09-28)
To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth. Systematic search through primary English-language literature on MEDLINE (1966-January 2001), EMBASE (1982-January 2001) and Current Contents (1998-January 2001). Genistein and daidzein at low concentrations
Columba de la Parra et al.
The Journal of biological chemistry, 287(50), 41640-41650 (2012-10-26)
Dietary soy is thought to be cancer-preventive; however, the beneficial effects of soy on established breast cancer is controversial. We recently demonstrated that dietary daidzein or combined soy isoflavones (genistein, daidzein, and glycitein) increased primary mammary tumor growth and metastasis.
H Gu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 689-692 (2013-01-29)
Daidzein, an estrogen-like product, has become increasingly popular as a dietary supplement, particularly for postpeak-estrus animals seeking a safe natural alternative to play a role of estrogen. However, there is little available safety data of it for raisers and consumers.
Azadeh Matin et al.
Journal of medicinal chemistry, 52(21), 6835-6850 (2009-10-08)
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARalpha and gamma agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel
S Paoletta et al.
Bioorganic & medicinal chemistry, 16(18), 8466-8470 (2008-09-10)
Random Forest screening of the phytochemical constituents of 240 herbs used in traditional Chinese medicine identified a number of compounds as potential inhibitors of the human aromatase enzyme (CYP19). Molecular modelling/docking studies indicated that three of these compounds (myricetin, liquiritigenin
Danielle R Ribeiro et al.
Basic & clinical pharmacology & toxicology, 117(2), 85-95 (2015-01-06)
We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by high-performance liquid chromatography (HPLC). Carcinogenesis was topically
Jorge Jesús Veloz et al.
BioMed research international, 2015, 291351-291351 (2015-08-08)
The chemical composition of propolis varies according to factors that could have an influence on its biological properties. Polyphenols from propolis have demonstrated an inhibitory effect on Streptococcus mutans growth. However, it is not known if different years of propolis
Eleonora Rizzi et al.
Bioorganic & medicinal chemistry letters, 15(19), 4313-4316 (2005-07-26)
A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.
Ronald Maul et al.
The British journal of nutrition, 103(11), 1569-1572 (2010-01-14)
In addition to soya-derived preparations, red clover-based dietary supplements have gained considerable interest as an alternative isoflavone (IF) source. While metabolism and bioavailability of the main IF from both sources have already been investigated, studies are still lacking on the
Clint M Alfaro et al.
Analytical chemistry, 86(21), 10639-10645 (2014-10-01)
With this study, we investigated why some small molecules demonstrate narrow dynamic ranges in electrospray ionization-mass spectrometry (ESI-MS) and sought to establish conditions under which the dynamic range could be extended. Working curves were compared for eight flavonoids and two
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry, 19(9), 2835-2841 (2011-04-16)
To search for a new class of antidiabetic compounds, effects of 44 flavonoids on the adipogenesis of 3T3-L1 cells were examined. Among them, 3,4',7-trimethylkaempferol, tetramethylkaempferol, and pentamethylquercetin concentration-dependently enhanced the accumulation of triglyceride, a marker of adipogenesis. With regard to
Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat
Retana-Marquez S, et al.
Physiology & Behavior, 164, 1-10 (2016)
Xin Dong et al.
Food chemistry, 135(3), 1643-1652 (2012-09-08)
Previous laboratory and animal studies reported that soy isoflavones were major bioactive compounds in soy to exert chemoprotection of prostate cancer. However, these studies cannot reflect the realistic effects that soy may induce through diets, and little is known about
Yiran Ma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 21-26 (2012-09-27)
An ultra-performance-liquid-chromatography-quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) method was developed and validated for the quantitation of daidzein (DZ) in rat plasma. Ethylparaben was chosen as internal standards (IS). DZ was linear over the range of 0.001-5 μg/mL. The lower limit of quantification
N Sathyamoorthy et al.
Cancer research, 54(4), 957-961 (1994-02-15)
Epidemiological studies suggest a lowered risk of hormone-dependent cancers among vegetarians, but the basis for this association remains unclear. Vegetables and fruits contain certain compounds which can be converted to biologically active hormone-like substances, such as lignans and isoflavones, by
Feng Li et al.
Bioorganic & medicinal chemistry, 16(10), 5434-5440 (2008-04-29)
Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for
Yuanyang Guo et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 52(6), 696-702 (2012-09-01)
To screen and identify a bacterium capable of converting daidzein to S-equol. We used antibiotics to limit unrelated bacterial growth and enrich the target bacteria, and isolated the aim bacterial strain from rat intestine. The metabolite of daidzein was tested
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