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Rachele M Pojednic et al.
Calcified tissue international, 96(3), 256-263 (2014-12-07)
Vitamin D receptor (VDR) expression and action in non-human skeletal muscle have recently been reported in several studies, yet data on the activity and expression of VDR in human muscle cells are scarce. We conducted a series of studies to
Bofan Yu et al.
Journal of chromatography. A, 1356, 221-229 (2014-07-07)
For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromatography (LV-DAI-GC) method was optimized for the following parameters: packed sorbent for sample
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
Rose and Philippa.
Joanne Whistler
Midwifery today with international midwife, (110)(110), 42-43 (2014-08-13)
E Xiao et al.
Stem cells (Dayton, Ohio), 33(2), 615-621 (2014-09-30)
Mesenchymal stem cells (MSCs) are multipotential stem cells residing in the bone marrow. Several studies have shown that mechanical stimulation modulates MSC differentiation through mobilization of second messengers, but the mechanism of mechanotransduction remains poorly understood. In this study, using
Sebastian Weiterer et al.
PloS one, 10(3), e0121748-e0121748 (2015-03-21)
Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted
Gerard Artigas et al.
Organic & biomolecular chemistry, 13(2), 452-464 (2014-11-06)
Tau pre-mRNA contains a stem-loop structure involved in the regulation of the alternative splicing of tau protein. We describe here a new family of Tau RNA ligands selected by dynamic combinatorial chemistry based on the combination of ametantrone with small
Dries J H De Clercq et al.
Chembiochem : a European journal of chemical biology, 16(5), 834-843 (2015-02-18)
We report the evaluation of two alternative chemical dimerizer approaches aimed at increasing the sensitivity of MASPIT, a three-hybrid system that enables small-molecule target protein profiling in intact human cells. To circumvent the potential limitations related to the binding of
Jia Kang et al.
Water environment research : a research publication of the Water Environment Federation, 86(3), 223-231 (2014-04-17)
The relationship between soluble microbial products (SMPs) and extracellular polymeric substances is described, and the characteristics of SMPs in the biological wastewater treatment process, including molecular weight distribution, metal-chelating property, biodegradability, biotoxicity, and membrane fouling, are investigated. The SMPs produced
Baoyu Zhao et al.
PloS one, 9(12), e115872-e115872 (2014-12-30)
Peptides are attracting increasing interest as protease inhibitors. Here, we demonstrate a new inhibitory mechanism and a new type of exosite interactions for a phage-displayed peptide library-derived competitive inhibitor, mupain-1 (CPAYSRYLDC), of the serine protease murine urokinase-type plasminogen activator (uPA).
Sofia Loren Butarbutar et al.
Radiation research, 182(6), 695-704 (2014-11-20)
A reliable understanding of radiolysis processes in supercritical water (SCW)-cooled reactors is crucial to developing chemistry control strategies that minimize the corrosion and degradation of materials. However, directly measuring the chemistry in reactor cores is difficult due to the extreme
Santiago Barreda et al.
Respiratory physiology & neurobiology, 208, 45-50 (2015-01-18)
Neonates at risk for sudden infant death syndrome (SIDS) are hospitalized for cardiorespiratory monitoring however, monitoring is costly and generates large quantities of averaged data that serve as poor predictors of infant risk. In this study we used a traditional
K Trautwein-Weidner et al.
Mucosal immunology, 8(2), 221-231 (2014-07-10)
Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for
Timothy M Martin et al.
The journal of gene medicine, 17(1-2), 14-32 (2015-02-11)
Design of efficient nonviral gene delivery systems is limited as a result of the rudimentary understanding of the specific molecules and processes that facilitate DNA transfer. Lipoplexes formed with Lipofectamine 2000 (LF2000) and plasmid-encoding green fluorescent protein (GFP) were delivered
Jeong-Yong Cho et al.
Bioscience, biotechnology, and biochemistry, 79(2), 260-270 (2014-10-29)
Changes in chemical constituent contents and DPPH radical-scavenging activity in fruits of pear (Pyrus pyrifolia) cultivars during the development were investigated. The fruits of seven cultivars (cv. Niitaka, Chuhwangbae, Wonhwang, Hwangkeumbae, Hwasan, Manpungbae, and Imamuraaki) were collected at 15-day intervals
M Lieveld et al.
Virchows Archiv : an international journal of pathology, 465(6), 703-713 (2014-10-12)
Giant cell tumor of bone (GCTB) displays worrisome clinical features such as local recurrence and occasionally metastatic disease which are unpredictable by morphology. Additional routinely usable biomarkers do not exist. Gene expression profiles of six clinically defined groups of GCTB
R M Aly et al.
International journal of laboratory hematology, 37(2), 272-278 (2014-08-06)
The Musashi-2 gene (MSI2) is implicated in leukemogenesis, and high MSI2 expression has been associated with decreased survival in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), suggesting its use as a new prognostic marker. We aimed to validate
Nicole Raquet et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 257-266 (2014-04-01)
Furocoumarins (FCs) are natural constituents widely occurring in plants used as food or in phytomedicines, cosmetics, etc. Some FCs exert dermal photo-toxicity and -genotoxicity when combined with UVA irradiation. For a few congeners, skin tumor formation has been described in
Yang Guo et al.
Journal of cellular and molecular medicine, 19(2), 340-350 (2014-10-22)
We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, cell
Raed Rizkallah et al.
Oncotarget, 6(3), 1446-1461 (2015-01-13)
TOPK/PBK is an oncogenic kinase upregulated in most human cancers and its high expression correlates with poor prognosis. TOPK is known to be activated by Cdk1 and needed for mitotic cell division; however, its mitotic functions are not yet fully
Karen Bakker et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 371(2002), 20130116-20130116 (2013-10-02)
Water governance is critical to water security, and to the long-term sustainability of the Earth's freshwater systems. This review examines recent debates regarding the governance dimensions of water security, including adaptive governance, polycentric governance, social learning and multi-level governance. The
Paola Pontieri et al.
Gene, 559(2), 177-183 (2015-02-04)
Mitochondria are eukaryotic organelles which contain the own genetic material and evolved from free-living Eubacteria, namely hydrogen-producing Alphaproteobacteria. Since 1965, biologists provided, by research at molecular level, evidence for the prokaryotic origins of mitochondria. However, determining the precise origins of
Akiharu Ueki et al.
Carbohydrate research, 405, 78-86 (2014-12-17)
Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are
Xin Guo et al.
FEBS letters, 589(4), 440-446 (2015-01-15)
During infection with human cytomegalovirus (HCMV), overexpression of hcmv-miR-US33 can inhibit the lytic viral replication and down-regulate US29 mRNA. However, it remains unknown whether inhibition of viral replication by miR-US33 is mediated by down-regulation of expression of US29 or another
Kija R Ng'habi et al.
Malaria journal, 14, 10-10 (2015-01-22)
Malaria still accounts for an estimated 207 million cases and 627,000 deaths worldwide each year. One proposed approach to complement existing malaria control methods is the release of genetically-modified (GM) and/or sterile male mosquitoes. As opposed to laboratory colonization, this
Nabile Boukhettala et al.
Journal of aerosol medicine and pulmonary drug delivery, 28(2), 130-136 (2014-07-23)
During mechanical ventilation, different aerosol generators are employed with various interfaces. The objective of this study was to evaluate the performance of a range of spacers, including a new device called Combihaler® designed for connection with both nebulizers and pressurized
J R Meinertz et al.
Journal of aquatic animal health, 26(4), 243-250 (2014-10-17)
Aquaflor is a feed premix for fish containing the broad spectrum antibacterial agent florfenicol (FFC) incorporated at a ratio of 50% (w/w). To enhance the effectiveness of FFC for salmonids infected with certain isolates of Flavobacterium psychrophilum causing cold water
Office construction or remodeling: are you going to LEED in 2014?
Lisa Knowles
The Journal of the Michigan Dental Association, 96(7), 34-35 (2014-08-29)
Karolina Pulka-Ziach et al.
Chembiochem : a European journal of chemical biology, 16(2), 293-301 (2014-12-10)
Cyclic peptides containing redox-stable thioether bridges might provide a useful alternative to disulfide-bridged bioactive peptides. We report the effect of replacing the disulfide bridge with a lanthionine linkage in a 16-mer cyclic peptide that binds to death receptor 5 (DR5
Liming Zhou et al.
Nature, 509(7498), 86-90 (2014-04-25)
Tropical forests are global epicentres of biodiversity and important modulators of climate change, and are mainly constrained by rainfall patterns. The severe short-term droughts that occurred recently in Amazonia have drawn attention to the vulnerability of tropical forests to climatic
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