GF77927170

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The iron-sensing fur regulator controls expression timing and levels of salmonella pathogenicity island 2 genes in the course of environmental acidification.

Eunna Choi et al.

Infection and immunity, 82(6), 2203-2210 (2014-03-20)

In order to survive inside macrophages, Salmonella produces a series of proteins encoded by genes within Salmonella pathogenicity island 2 (SPI-2). In the present study, we report that Fur, a central regulator of iron utilization, negatively controls the expression of

Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.

Magnus Steigedal et al.

Journal of immunology (Baltimore, Md. : 1950), 193(12), 6081-6089 (2014-11-16)

Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.

Goldie Y L Lui et al.

Molecular pharmacology, 87(3), 543-560 (2015-01-07)

Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatment. Here, we reveal how the iron-binding ligands desferrioxamine (DFO), di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit constitutive and interleukin 6-induced activation of signal transducer and

Effect of anions and humic acid on the performance of nanoscale zero-valent iron particles coated with polyacrylic acid.

Hong-Seok Kim et al.

Chemosphere, 113, 93-100 (2014-07-30)

Effects of anions (NO3(-), HCO3(-), Cl(-), SO4(2-)) and humic acid on the reactivity and core/shell chemistries of polyacrylic acid-coated nanoscale zero-valent iron (PAA-NZVI) and inorganically modified NZVI (INORG-NZVI) particles were investigated. The reactivity tests under various ion concentrations (0.2-30mN) revealed

Ocean chemistry: Fingerprints of a trace nutrient.

Joseph A Resing et al.

Nature, 511(7508), 164-165 (2014-07-11)

Microcytic anemia.

Thomas G DeLoughery

The New England journal of medicine, 371(26), 2537-2537 (2014-12-30)

The role of reduced iron powder in the fermentative production of tetanus toxin.

Arnold L Demain et al.

Applied microbiology and biotechnology, 73(1), 55-59 (2006-04-20)

When tetanus toxin is made by fermentation with Clostridium tetani, the traditional source of iron is an insoluble preparation called reduced iron powder. This material removes oxygen from the system by forming FeO(2) (rust). When inoculated in a newly developed

Iron, inflammation, and early death in adults with sickle cell disease.

Eduard J van Beers et al.

Circulation research, 116(2), 298-306 (2014-11-08)

Patients with sickle cell disease (SCD) have markers of chronic inflammation, but the mechanism of inflammation and its relevance to patient survival are unknown. To assess the relationship between iron, inflammation, and early death in SCD. Using peripheral blood mononuclear

Engineering rhizobial bioinoculants: a strategy to improve iron nutrition.

S J Geetha et al.

TheScientificWorldJournal, 2013, 315890-315890 (2013-12-10)

Under field conditions, inoculated rhizobial strains are at a survival disadvantage as compared to indigenous strains. In order to out-compete native rhizobia it is not only important to develop strong nodulation efficiency but also increase their competence in the soil

Analytical, nutritional and biological evaluation of various brands of fortified and non-fortified wheat flour.

Sohail Amjad et al.

Pakistan journal of pharmaceutical sciences, 27(3), 445-452 (2014-05-09)

In Pakistan, a funded flour fortification program was launched for malnourished population, residing mainly in rural low income areas, but the urban population having comparatively better nutritional as well as economic status was focused wherein excessive intake of fortificants might

Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Yatrik M Shah et al.

Gastroenterology, 146(3), 630-642 (2014-01-07)

Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is

Iron: effect of overload and deficiency.

Robert C Hider et al.

Metal ions in life sciences, 13, 229-294 (2014-01-29)

Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being

Membrane-integrated hybrid system for the effective treatment of ammoniacal wastewater of coke-making plant: a volume reduction approach.

Ramesh Kumar et al.

Environmental technology, 35(13-16), 2018-2027 (2014-06-25)

Nanofiltration (NF) of ammoniacal wastewater containing phenol and cyanide has been investigated for effective separation of these hazardous pollutants and for the subsequent downstream chemical treatment resulting in valuable by-product generation. Four different types of composite polyamide commercial NF membranes

Vasoactive effects of stable aqueous suspensions of single walled carbon nanotubes in hamsters and mice.

Mary D Frame et al.

Nanotoxicology, 8(8), 867-875 (2013-09-03)

Single-walled carbon nanotubes synthesized with iron (Fe-SWCNT) or gadolinium (Gd-SWCNT) show promise as high performance multimodal contrast and drug-delivery agents. Our purpose was to evaluate potential vasoactive effects of SWCNT. Stable aqueous solutions of Fe-SWCNTs or Gd-SWCNTs were made using

50 years ago in the Journal of Pediatrics: Iron metabolism in premature infants: II. Prevention of iron deficiency.

Pamela J Kling

The Journal of pediatrics, 164(4), 768-768 (2014-03-22)

[Children's iron needs and how we best can protect the child's brain].

Staffan Berglund et al.

Lakartidningen, 111(11), 460-463 (2014-04-12)

Pre-operative anaemia.

B Clevenger et al.

Anaesthesia, 70 Suppl 1, 20-28 (2014-12-03)

Pre-operative anaemia is a relatively common finding, affecting a third of patients undergoing elective surgery. Traditionally associated with chronic disease, management has historically focused on the use of blood transfusion as a solution for anaemia in the peri-operative period. Data

Development of an Escherichia coli K12-specific quantitative polymerase chain reaction assay and DNA isolation suited to biofilms associated with iron drinking water pipe corrosion products.

Jingrang Lu et al.

Journal of water and health, 12(4), 763-771 (2014-12-05)

A quantitative polymerase chain reaction assay (115 bp amplicon) specific to Escherichia coli K12 with an ABI(TM) internal control was developed based on sequence data encoding the rfb gene cluster. Assay specificity was evaluated using three E. coli K12 strains

Four-fold channels are involved in iron diffusion into the inner cavity of plant ferritin.

Chenyan Lv et al.

Biochemistry, 53(14), 2232-2241 (2014-04-01)

From an evolutionary point of view, plant and animal ferritins arose from a common ancestor, but plant ferritin exhibits different features as compared with the animal analogue. One major difference is that the 4-fold channels naturally occurring in plant ferritin

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.

Yan Zhang et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1695-E1704 (2014-04-16)

Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inactivation, and reactivation are poorly

Reduced prevalence of Giardia duodenalis in iron-deficient Rwandan children.

Ina Danquah et al.

Tropical medicine & international health : TM & IH, 19(5), 563-567 (2014-06-06)

Acute symptomatic infection with Giardia duodenalis impairs iron absorption, but iron deficiency may protect against infections caused by various micro-organisms including parasites. We therefore examined the association of G. duodenalis infection and iron deficiency in 575 Rwandan children under 5

Effect of maternal multiple micronutrient vs iron-folic acid supplementation on infant mortality and adverse birth outcomes in rural Bangladesh: the JiVitA-3 randomized trial.

Keith P West et al.

JAMA, 312(24), 2649-2658 (2014-12-24)

Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia. To assess effects of antenatal multiple micronutrient vs iron-folic acid supplementation on

Role of iron in lung injury-induced by hyperoxia.

D Cao et al.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 41(1), 27-31 (2014-03-22)

Iron is essential to life due to its unusual flexibility in serving as both an electron donor and acceptor. However, free iron can damage tissues by catalyzing the conversion of hydrogen peroxide to free-radical ions that attack lipids, proteins and

Nanofiltration and Fenton's process over iron shavings for surfactants removal.

Rui C Martins et al.

Environmental technology, 35(17-20), 2380-2388 (2014-08-26)

The presence of surfactants in wastewater composition tends to jeopardize the efficiency of the traditional aerobic treatment processes. In this regard, the application of Fenton's reaction and nanofiltration as single processes and integrated (nanofiltration followed by Fenton's process) was investigated

Metachelins, mannosylated and N-oxidized coprogen-type siderophores from Metarhizium robertsii.

Stuart B Krasnoff et al.

Journal of natural products, 77(7), 1685-1692 (2014-07-06)

Under iron-depleted culture conditions, the entomopathogenic fungus Metarhizium robertsii (Bischoff, Humber, and Rehner) (= M. anisopliae) produces a complex of extracellular siderophores including novel O-glycosylated and N-oxidized coprogen-type compounds as well as the known fungal siderophores N(α)-dimethylcoprogen (NADC) and dimerumic

Reference method for measurement of the hepatic iron concentration.

Gary M Brittenham

American journal of hematology, 90(2), 85-86 (2014-12-10)

Iron therapy in anaemic adults without chronic kidney disease.

Kurinchi Selvan Gurusamy et al.

The Cochrane database of systematic reviews, 12(12), CD010640-CD010640 (2015-01-01)

Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not

Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer.

Ellinor I B Peerschke et al.

American journal of clinical pathology, 142(4), 506-512 (2014-09-23)

Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 μg/dL

Sulfur-mediated electron shuttling during bacterial iron reduction.

Theodore M Flynn et al.

Science (New York, N.Y.), 344(6187), 1039-1042 (2014-05-03)

Microbial reduction of ferric iron [Fe(III)] is an important biogeochemical process in anoxic aquifers. Depending on groundwater pH, dissimilatory metal-reducing bacteria can also respire alternative electron acceptors to survive, including elemental sulfur (S(0)). To understand the interplay of Fe/S cycling

Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae.

Thomas A Russo et al.

Infection and immunity, 82(6), 2356-2367 (2014-03-26)

Hypervirulent (hypermucoviscous) Klebsiella pneumoniae (hvKP) strains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatening infection in healthy individuals. An understanding of hvKP-specific virulence mechanisms that enabled evolution from cKP is limited. Observations by our

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