搜索范围
H1758
应用筛选条件
关键词:'H1758'
显示 1-30 #N/A 2860 条结果 关于 "H1758" 范围 论文
Eduardo Parra et al.
Oncology reports, 33(1), 413-418 (2014-10-30)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling
Sayed M Derayea et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 655-660 (2015-10-12)
A new validated spectrofluorimetric method has been developed for the determination of some cephalosporins namely; cefepime, cefaclor, cefadroxil, cefpodoxime and cefexime. The method was based on the reaction of these drugs with safranin in slightly alkaline medium (pH 8.0), to
Kimberly R Doherty et al.
Toxicology and applied pharmacology, 285(1), 51-60 (2015-04-07)
Safety pharmacology studies that evaluate new drug entities for potential cardiac liability remain a critical component of drug development. Current studies have shown that in vitro tests utilizing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) may be beneficial for preclinical
Shamin Mohd Saffian et al.
Bioanalysis, 7(8), 957-966 (2015-05-13)
An assay for the quantification of dabigatran and its active metabolites, dabigatran acylglucuronides, has not previously been described in detail. For the quantification of total dabigatran concentration (free dabigatran and acylglucuronides), samples were subjected to alkaline hydrolysis. For the quantification
XiaoNing Chen et al.
PloS one, 10(5), e0125802-e0125802 (2015-05-06)
Birdsongs and the regions of their brain that control song exhibit obvious sexual differences. However, the mechanisms underlying these sexual dimorphisms remain unknown. To address this issue, we first examined apoptotic cells labeled with caspase-3 or TUNEL in Bengalese finch
Mass-spectrometry-based method for screening of new peptide ligands for G-protein-coupled receptors.
Camila T Cologna et al.
Analytical and bioanalytical chemistry, 407(18), 5299-5307 (2015-05-04)
G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane proteins. Although implicated in almost all physiological processes in the human body, most of them remain unexploited, mostly because of the lack of specific ligands. The objective of this work is
Hejun Liu et al.
Immunity, 53(6), 1272-1280 (2020-11-27)
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, COVA1-16 is a relatively rare antibody that also cross-neutralizes SARS-CoV. Here, we determined a crystal structure of the COVA1-16
A Ferrer et al.
Bioresource technology, 132, 115-120 (2013-02-12)
Influence of operational variables in the EFB pulping [acetic acid (60-95%), hydrochloric acid (0.10-0.25%) and time (60-180 min)], on the yield, drainability or beating grade, Kappa number, lignin and viscosity of pulps was studied. By using a factorial design, equations
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
Filippa Fleetwood et al.
Scientific reports, 4, 7518-7518 (2014-12-18)
Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic targets.
Kazumasu Sasaki et al.
British journal of pharmacology, 172(2), 654-667 (2014-06-11)
μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we
Hwee Ling Poh et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(22), 8130-8136 (2015-04-17)
Covalently functionalized graphene materials with well-defined stoichiometric composition are of a very high importance in the research of 2D carbon material family due to their well-defined properties. Unfortunately, most of the contemporary graphene-functionalized materials do not have this kind of
Sumitra Miriyala et al.
The international journal of biochemistry & cell biology, 68, 70-77 (2015-09-01)
Impaired cardiovascular function during acute myocardial infarction (MI) is partly associated with recruitment of activated polymorphonuclear neutrophils. The protective role of arjunolic acid (AA; 2,3,23-trihydroxy olean-12-en-28-oic acid) is studied in the modulation of neutrophil functions in vitro by measuring the
Wei-Wei Zhao et al.
Journal of chromatography. A, 1370, 121-128 (2014-12-03)
Metal-organic frameworks (MOFs) have great potential for applications in chromatography due to their highly tailorable porous structures and unique properties. In this work, the stable MOF UiO-66 was evaluated as both a normal-phase (NP-) and a reverse-phase (RP-) stationary phase
Munawar Hussain et al.
Talanta, 147, 1-7 (2015-11-26)
We present a fast, robust and straightforward spin force assisted surface imprinting approach for activated platelets and demonstrate that Heparin induced thrombocytopenia (HIT) platelet aggregation can be measured by this approach. A critical and challenging step in functional assays for
A Dadkhah et al.
Pharmaceutical biology, 53(2), 220-227 (2014-09-23)
Achillea wilhelmsii C. Koch (Asteraceae) is widely used in Iranian traditional medicine. This in vivo study evaluates the hepatoprotective role of Iranian A. wilhelmsii oils against acetaminophen-induced oxidative damages in rats. The animals were divided into five groups: in negative
M A García-Sevillano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 75-84 (2015-02-11)
Although mercury (Hg) is an important environmental and occupational pollutant, its toxicological effects, especially in serum and red blood cells (RBCs), have been scarcely studied. A toxicometabolomics workflow based on high resolution mass spectrometry approaches has been applied to investigate
Bukar Umaru et al.
The Journal of pharmacology and experimental therapeutics, 354(1), 79-87 (2015-05-16)
Intense research is conducted to identify new molecular mechanisms of angiogenesis. Previous studies have shown that the angiogenic effects of hydrogen sulfide (H2S) depend on the activation of ATP-sensitive potassium channels (KATP) and that C-type natriuretic peptide (CNP), which can
Tobias Glaser et al.
The journal of physical chemistry letters, 6(15), 2913-2918 (2015-08-13)
The organic cation and its interplay with the inorganic lattice underlie the exceptional optoelectronic properties of organo-metallic halide perovskites. Herein we report high-quality infrared spectroscopic measurements of methylammonium lead halide perovskite (CH3NH3Pb(I/Br/Cl)3) films and single crystals at room temperature, from
Arturo Luna-Tapia et al.
Antimicrobial agents and chemotherapy, 59(4), 2410-2420 (2015-02-11)
The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of "toxic" sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion upon the
Anna Russo et al.
PloS one, 10(8), e0133571-e0133571 (2015-08-08)
Short peptides can be designed in silico and synthesized through automated techniques, making them advantageous and versatile protein binders. A number of docking-based algorithms allow for a computational screening of peptides as binders. Here we developed ex-novo peptides targeting the
Ismail M Fareez et al.
International journal of biological macromolecules, 72, 1419-1428 (2014-12-03)
The vulnerability of probiotics at low pH and high temperature has limited their optimal use as nutraceuticals. This study addressed these issues by adopting a physicochemical driven approach of incorporating Lactobacillus plantarum LAB12 into chitosan (Ch) coated alginate-xanthan gum (Alg-XG)
Helen A Swarbrick et al.
Ophthalmology, 122(3), 620-630 (2014-12-03)
To investigate the effect of overnight orthokeratology (OK) contact lens wear on axial length growth in East Asian children with progressive myopia. A prospective, randomized, contralateral-eye crossover study conducted over a 1-year period. We enrolled 26 myopic children (age range
Naiyana Gujral et al.
BMC immunology, 16, 41-41 (2015-07-15)
Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complications seen in the pathogenesis of celiac disease (CD). In this study, specific anti-gliadin IgY antibody
Hanno C Erythropel et al.
Chemosphere, 134, 106-112 (2015-04-29)
The ubiquitous presence of the plasticizer di (2-ethylhexyl) phthalate (DEHP) in the environment is of concern due to negative biological effects associated with it and its metabolites. In particular, the metabolite mono (2-ethylhexyl) phthalate (MEHP) is a potential endocrine disruptor.
Raquel García-González et al.
Talanta, 142, 11-19 (2015-05-25)
Amplification-free (referring to enzymatic amplification step) detection methodologies are increasing in biosensor development due to the need of faster and simpler protocols. However, for maintaining sensitivity without this step, highly detectable molecules or very sensitive detection techniques are required. The
Fu-Chen Kung et al.
Materials science & engineering. C, Materials for biological applications, 45, 578-588 (2014-12-11)
Electrospun fiber sheets with various orientations (random, partially aligned, and aligned) and smooth and roughened casted membranes were prepared. Hydroxyapatite (HA) crystals were in situ formed on these material surfaces via immersion in 10× simulated body fluid solution. The size
Eva Vergaño-Vera et al.
Developmental neurobiology, 75(8), 823-841 (2014-12-03)
The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it remains unknown whether it influences the generation of dopaminergic neurons (DA) (DA neurons) in cells isolated from this brain region. We found that expressing Nurr1 in
Sebastian J Kapp et al.
Journal of pharmaceutical sciences, 104(2), 593-601 (2014-12-03)
Two monoclonal antibodies from the IgG subclasses one and two were compared in their adsorption behavior with hydrophobic surfaces upon dilution to 10 mg/mL with 0.9% NaCl. These conditions simulate handling of the compounds at hospital pharmacies and surfaces encountered
Yosuke Senju et al.
Journal of cell science, 128(15), 2766-2780 (2015-06-21)
PACSIN2, a membrane-sculpting BAR domain protein, localizes to caveolae. Here, we found that protein kinase C (PKC) phosphorylates PACSIN2 at serine 313, thereby decreasing its membrane binding and tubulation capacities. Concomitantly, phosphorylation decreased the time span for which caveolae could
1/96