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Fiona D Zeeb et al.
Psychopharmacology, 232(24), 4481-4491 (2015-09-22)
Studies employing the Iowa Gambling Task (IGT) demonstrated that areas of the frontal cortex, including the ventromedial prefrontal cortex, orbitofrontal cortex (OFC), dorsolateral prefrontal cortex, and anterior cingulate cortex (ACC), are involved in the decision-making process. However, the precise role
O A Adaramoye et al.
The West Indian medical journal, 63(5), 408-415 (2015-03-18)
To evaluate and compare the antioxidant and acetylcholinestrase (AChE)-inhibitory properties of aerial parts of Strophanthus preussii (leaves, stem and root named as SPL, SPS and SPR, respectively) while catechin served as standard. The antioxidant and AchE-inhibitory properties of the methanol
S Orlandini et al.
Journal of chromatography. A, 1380, 177-185 (2015-01-15)
Quality by design (QbD) concepts, in accordance with International Conference on Harmonisation Pharmaceutical Development guideline Q8(R2), represent an innovative strategy for the development of analytical methods. In this paper QbD principles have been comprehensively applied in the set-up of a
Juan Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6965-6972 (2015-04-11)
The aim of this study was to explore the expression and clinical significance of miR-494 and PTEN (phosphatase and tensin homologue deleted on chromosome ten) in non-small cell lung cancer (NSCLC). Immunohistochemistry for PTEN and in situ hybridization (ISH) for
Manish Jindal et al.
Carbohydrate polymers, 93(2), 386-394 (2013-03-19)
Pectin is used in a number of foods as a gelling agent, thickener, texturizer, emulsifier and stabilizer. Bael fruit, obtained from Aegle marmelos, is a rich source of pectin. Bael fruit pectin (BFP) was extracted from ripe Bael fruits. The
Aleksandar Lolić et al.
The Science of the total environment, 508, 240-250 (2014-12-08)
The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial
Malgorzata M Brzoska et al.
Current drug targets, 16(13), 1470-1487 (2015-01-06)
Recently a growing attention has been paid to the possibility of using biologically active compounds, including polyphenols, for the prevention of unfavourable effects of exposure to xenobiotics. The study was aimed to investigate, in a female rat model, whether consumption
Marian Vincenzi et al.
International journal of molecular sciences, 16(6), 12159-12173 (2015-06-02)
This work reports on the design and the synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means
Supeeraya Arsa et al.
Journal of food science and technology, 52(8), 5285-5291 (2015-08-06)
The sensory aroma characteristics of alcalase hydrolyzed rice bran protein concentrate as affected by spray drying and sugar addition were investigated. Rice bran protein concentrate (RBPC) was hydrolyzed by alcalase. Sucrose, glucose or fructose was added to the liquid rice
Q Miao et al.
Physical review letters, 109(23), 233905-233905 (2013-02-02)
X-ray lasing is predicted to ensue when molecules are pumped into dissociative core-excited states by a free-electron-laser pulse. The lasing is due to the population inversion created in the neutral dissociation product, and the process features self-trapping of the x-ray
Nur Hande Tüfek et al.
Systems biology in reproductive medicine, 61(4), 194-204 (2015-06-05)
Thymoquinone (TQ) is a phytochemical compound found in the plant Nigella sativa. It has antioxidant and anti-cancer effects. This study investigated the effects of TQ on obesity and testicular structure of high-fat-diet (HFD) fed rats. Obese control (OC) and obese
Gökçe Hatipoglu et al.
Cancer science, 106(2), 160-170 (2014-12-03)
Malignant gliomas can be counted to the most devastating tumors in humans. Novel therapies do not achieve significant prolonged survival rates. The cancer cells have an impact on the surrounding vital tissue and form tumor zones, which make up the
Hanne Sørup Tastesen et al.
PloS one, 9(11), e112859-e112859 (2014-11-13)
Low-protein and high-protein diets regulate energy metabolism in animals and humans. To evaluate whether different dietary protein sources modulate energy balance when ingested at average levels obesity-prone male C57BL/6J mice were pair-fed high-fat diets (67 energy percent fat, 18 energy
Akiva N Rappaport et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15568-15581 (2015-11-27)
Learning of novel information, including novel taste, requires activation of neuromodulatory transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant brain structures. In addition, drugs enhancing the function of mAChRs are used to treat memory impairment and
Rodrigo J Carbajo et al.
The FEBS journal, 282(2), 341-360 (2014-11-05)
Extant disintegrins, as found in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes, represent a family of polypeptides that block the function of β1 and β3 integrin receptors, both potently and with a high degree of selectivity. This
Amir Kol et al.
Stem cell research & therapy, 6, 73-73 (2015-04-19)
Intravenous (IV) injection of mesenchymal stem cells (MSCs) is used to treat systemic human diseases and disorders but is not routinely used in equine therapy. In horses, MSCs are isolated primarily from adipose tissue (AT) or bone marrow (BM) and
Micky Fu Xiang Lee et al.
Journal of chromatography. A, 1394, 71-80 (2015-04-04)
A thermo-responsive random copolymer, POEGMA (poly(oligoethylene glycol) methacrylate) grafted on cationized agarose adsorbent was used for size selective protein adsorption. The effects of OEGMA300 ((oligoethylene glycol) methyl ether methacrylate, Mn=300g/mol) content and temperature on the adsorption of bovine serum albumin
Jing Ma et al.
Scientific reports, 5, 12079-12079 (2015-07-16)
Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We investigated the temporal effects of minocycline on an experimental SIVD exerted by right unilateral common
Şerife Parlayıcı et al.
Environmental monitoring and assessment, 187(12), 763-763 (2015-11-20)
The biosorption of Cr(VI) by the garlic stem (GS)-Allium sativum L. and horse chesnut shell (HCS)-Aesculus hippocastanum plant residues in a batch type reactor was studied in detail for the purpose of wastewater treatment. The influence of initial Cr(VI) concentration
Elisabeth Pinart et al.
Theriogenology, 83(9), 1525-1533 (2015-03-10)
The main aim of this study was to determine whether acrosin activity could predict boar sperm freezability. For this purpose, we characterized the changes in sperm quality and acrosin activity throughout the cryopreservation procedure of sperm samples from 30 Pietrain
Melanie M Hoefer et al.
Experimental neurology, 263, 221-234 (2014-09-24)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the
Melania Melis et al.
PloS one, 10(6), e0131104-e0131104 (2015-06-24)
Genetic variation in the ability to taste the bitterness of 6-n-propylthiouracil (PROP) is a complex trait that has been used to predict food preferences and eating habits. PROP tasting is primarily controlled by polymorphisms in the TAS2R38 gene. However, a
Zhonghua Zhang et al.
The Plant cell, 27(6), 1595-1604 (2015-05-24)
Structural variations (SVs) represent a major source of genetic diversity. However, the functional impact and formation mechanisms of SVs in plant genomes remain largely unexplored. Here, we report a nucleotide-resolution SV map of cucumber (Cucumis sativas) that comprises 26,788 SVs
Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells.
Sung-Kyun Ko et al.
Nature chemistry, 6(10), 885-892 (2014-09-23)
Anion transporters based on small molecules have received attention as therapeutic agents because of their potential to disrupt cellular ion homeostasis. However, a direct correlation between a change in cellular chloride anion concentration and cytotoxicity has not been established for
Lina Lu et al.
Toxins, 7(5), 1738-1748 (2015-05-23)
Celangulin V, an insecticidal compound isolated from the root bark of Chinese bittersweet, can affect the digestive system of insects. However, the mechanism of how Celangulin V induces a series of symptoms is still unknown. In this study, affinity chromatography
Farhana Abedin et al.
Journal of biomaterials applications, 30(1), 38-49 (2015-02-02)
Albumin-based drug-carrying micro-composite spheres were fabricated and studied to evaluate their potentials for breast cancer treatment. Magnetic nanoparticles and albumin were incorporated within poly(D l-lactide-co-glycolide) microspheres to increase accumulation of the microspheres at the target site. Two chemotherapeutics, cyclophosphamide and
Yuwei Zhu et al.
The Biochemical journal, 470(1), 105-114 (2015-08-08)
UbiG and Coq3 (orthologue in eukaryotes) are SAM-MTases (S-adenosylmethionine-dependent methyltransferases) that catalyse both O-methylation steps in CoQ biosynthesis from prokaryotes to eukaryotes. However, the detailed molecular mechanism by which they function remains elusive. In the present paper, we report that
João M N Duarte et al.
Journal of neuroscience research, 93(7), 1009-1018 (2014-12-19)
The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate
Qing Zhang et al.
The Analyst, 140(15), 5235-5242 (2015-06-13)
In this work, needle-like and micro-spherical agglomerates of nanocrystalline hydroxyapatite (HA) were successfully assembled on the surface of graphene sheets with the aid of dopamine having two roles, as a template and a reductant for graphite oxide during the process
Dorota Nieweglowska et al.
Reproductive biology and endocrinology : RB&E, 13, 128-128 (2015-11-26)
Endometriosis is a well-known cause of infertility, and the anti-Mullerian hormone (AMH) is an accepted biomarker of ovarian reserve and response to artificial reproductive technology procedures. The present study was a prospective analysis of age-dependent AMH serum concentration in women
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