CN
H9892
应用筛选条件
关键词:'H9892'
显示 1-30 共 2745 条结果 关于 "H9892" 范围 论文
Maged W Helmy et al.
British journal of pharmacology, 172(17), 4291-4302 (2015-05-28)
Cyclosporine (CSA) and non-steroidal anti-inflammatory drugs (NSAIDs) are co-prescribed for some arthritic conditions. We tested the hypothesis that this combined regimen elicits exaggerated nephrotoxicity in rats via the up-regulation of endothelin (ET) receptor signalling. The effects of a 10 day
Heloisa R Cadorim et al.
Talanta, 146, 203-208 (2015-12-24)
An analytical method for the determination of sulfur, as the tin mono-sulfide (SnS) molecule, in crude oil using high-resolution continuum source graphite furnace molecular absorption spectrometry (HR-CS GF MAS) has been developed. The molecular absorbance of the SnS has been
Pilar Puig-Sàrries et al.
The Biochemical journal, 469(3), 455-467 (2015-07-25)
Despite being a common mechanism in eukaryotes, the process by which protein monoubiquitination is produced and regulated in vivo is not completely understood. We present here the analysis of the process of monoubiquitination of the proteasomal subunit Rpn10 (regulatory particle non-ATPase
Jung-Seok Lee et al.
Journal of biomedical materials research. Part A, 103(2), 545-554 (2014-04-26)
There is growing concern about unwanted effects associated with the clinical use of recombinant human bone morphogenetic protein-2 (rhBMP-2) at high concentrations, including cyst-like bone formation and excessive fatty marrow formation. We, therefore, evaluated the induction of mineralized/adipose tissue formation
Milena Sokolowska et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5472-5487 (2015-04-29)
PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucine-rich repeat-containing protein (NLR)P3 inflammasome plays an important role in host defense. Uncontrolled activation
Jennifer Winstanley et al.
eLife, 4 (2015-02-03)
Members of the Tolloid family of metalloproteinases liberate BMPs from inhibitory complexes to regulate BMP gradient formation during embryonic dorsal-ventral axis patterning. Here, we determine mechanistically how Tolloid activity is regulated by its non-catalytic CUB domains in the Drosophila embryo.
Pieter Uvin et al.
European urology, 68(4), 655-661 (2015-04-07)
Acute exposure of part of the skin to cold stimuli can evoke urinary urgency, a phenomenon termed acute cold-induced urgency (ACIU). Despite its high prevalence, particularly in patients with overactive bladder, little is known about the mechanisms that induce ACIU.
Dusmant Maharana et al.
Chemosphere, 136, 145-152 (2015-05-20)
Electrochemical oxidation of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) over metal-oxide-coated Ti anodes, i.e., Ti/SnO2-Sb/Ce-PbO2, Ti/SnO2-Sb and Ti/RuO2, was examined. The degradation efficiency of over 90% was attained at 20 min at different initial concentrations (0.5-20 mg L(-1)) and initial pH values (3.1-11.2).
Franck A Ditengou et al.
Nature communications, 6, 6279-6279 (2015-02-24)
The mutualistic association of roots with ectomycorrhizal fungi promotes plant health and is a hallmark of boreal and temperate forests worldwide. In the pre-colonization phase, before direct contact, lateral root (LR) production is massively stimulated, yet little is known about
Derya Kara et al.
Food chemistry, 188, 143-148 (2015-06-05)
The aim of this study is to develop a new method for the extraction and preconcentration of trace elements from edible oils via an ultrasound-assisted extraction using ethylenediaminetetraacetic acid (EDTA) producing detergentless microemulsions. These were then analyzed using ICP-MS against
The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo.
Antonio Barbieri et al.
International journal of oncology, 47(2), 527-534 (2015-06-11)
The metastatic process is the most serious cause of cancer death. Norepinephrine, secreted in chronic stress conditions, stimulates the motility of breast and colon cells through β-adrenergic receptor. On these bases, we examined its possible role in metastasis formation and
Manuel Candelario et al.
Journal of ethnopharmacology, 171, 264-272 (2015-06-13)
Withania somnifera (WS) has been traditionally used in Ayurvedic medicine as a remedy for debility, stress, nervous exhaustion, insomnia, loss of memory, and to enhance cognitive function. This study provides an empirical evidence to support the traditional use of WS
Wenying Fan et al.
The Analyst, 140(12), 4057-4067 (2015-04-16)
In this work, a molecularly imprinted polymer (MIP) coated stir bar was prepared using a self-designed polytetrafluoroethylene (PTFE) mold and in situ polymerization, with cyromazine as the dummy template for the target melamine. The prepared MIP coated stir bar presented
Paolo Piatti et al.
Scientific reports, 5, 8007-8007 (2015-01-27)
The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and pluripotency in embryonic stem cells (ESCs). Here we have studied the effects of a partial deletion
M C Buss et al.
Oncogene, 34(9), 1126-1140 (2014-03-19)
Recent studies suggest that medulloblastoma, the most common malignant brain tumor of childhood, is comprised of four disease variants. The WIP1 oncogene is overexpressed in Group 3 and 4 tumors, which contain medulloblastomas with the most aggressive clinical behavior. Our
Marco Roverso et al.
Metallomics : integrated biometal science, 7(7), 1146-1154 (2015-04-29)
Obtaining the knowledge of the "omics" and therefore of the metallomics of gestational diabetes mellitus (GDM) appears to be a necessary task to obtain information about the molecular causes of this disease. In this study, the metallome of GDM and
Wonkyoung Cho et al.
PloS one, 10(6), e0130587-e0130587 (2015-06-26)
Atherosclerosis, the major pathology of cardiovascular disease, is caused by multiple factors involving psychological stress. Corticotropin-releasing hormone (CRH), which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals and epithelial cells, regulates various stress-related responses. Our current study
A J Esbaugh et al.
Aquatic toxicology (Amsterdam, Netherlands), 130-131, 27-30 (2013-01-24)
The toxicity of many metals is impacted by environmental pH, through both competition and complexation by hydroxide and carbonate ions. To establish safe environmental regulation it is important to properly define the relationship between pH and metal toxicity, a process
M A Babcook et al.
Cell death & disease, 5, e1536-e1536 (2014-11-21)
Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis, in part, due to enhanced aerobic glycolysis and biomass production, known as the Warburg effect. We previously demonstrated that combination simvastatin (SIM) and metformin (MET) ameliorates critical Warburg effect-related
Óscar Cordero-Llana et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 244-254 (2014-11-06)
Cerebral Dopamine Neurotrophic Factor (CDNF) and Mesencephalic Astrocyte-derived Neurotrophic factor (MANF) are members of a recently discovered family of neurotrophic factors (NTFs). Here, we used intranigral or intrastriatal lentiviral vector-mediated expression to evaluate their efficacy at protecting dopaminergic function in
Andreas Hecker et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2325-2334 (2015-07-24)
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and
Craig S Schneider et al.
Biomaterials, 42, 42-51 (2014-12-30)
A major limitation in the treatment of glioblastoma (GBM), the most common and deadly primary brain cancer, is delivery of therapeutics to invading tumor cells outside of the area that is safe for surgical removal. A promising way to target
Li Li et al.
PloS one, 10(7), e0132827-e0132827 (2015-07-18)
Archaeological silk provides abundant information for studying ancient technologies and cultures. However, due to the spontaneous degradation and the damages from burial conditions, most ancient silk fibers which suffered the damages for thousands of years were turned into invisible molecular
Kuei-Chen Chang et al.
Environmental science and pollution research international, 22(17), 13234-13242 (2015-05-06)
Polycyclic aromatic compounds (PACs) are widespread environmental pollutants with a high potential to act as human carcinogens and mutagens. The behavior of PACs is significantly affected by their interactions with dissolved organic matter (DOM), such as their transport, solubility, bioavailability
Elena N Makarova et al.
Carbohydrate polymers, 92(2), 1817-1826 (2013-02-13)
The pectic polysaccharide named abienan AS-A was isolated from the wood greenery of Abies sibirica using dilute hydrochloric acid (pH 4.0) at 70°C. The structure of abienan AS-A was elucidated using sugar composition analysis, ion-exchange chromatography and partial acid hydrolysis
Kyeung A Ryu et al.
PloS one, 10(8), e0136617-e0136617 (2015-08-27)
The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p<0.05).
A Kaufmann et al.
Analytica chimica acta, 862, 41-52 (2015-02-16)
An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran and chloramphenicol residues in a number of animal based food products. This method is based
Nathan Wolf et al.
Rapid communications in mass spectrometry : RCM, 29(15), 1448-1456 (2015-07-07)
The eco-physiological mechanisms that govern the incorporation and routing of macronutrients from dietary sources into consumer tissues determine the efficacy of stable isotope analysis (SIA) for studying animal foraging ecology. We document how changes in the relative amounts of dietary
Hui-Ning Fan et al.
Molecular medicine reports, 12(3), 3351-3358 (2015-06-03)
The present study aimed to investigate the effects of endogenous hydrogen sulfide (H2S) on the expression levels of angiotensin II type 1 receptor (AGTR1) in a rat model of carbon tetrachloride (CCl4)‑induced hepatic fibrosis. A total of 56 Wistar rats
Elizabeth A Ennis et al.
ACS chemical neuroscience, 6(3), 417-427 (2015-01-07)
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a high-throughput screen for
1/92