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Martin Knaus et al.
Veterinary parasitology, 202(1-2), 64-68 (2014-04-08)
The efficacy of a novel topical combination of fipronil 8.3% w/v, (S)-methoprene 10% w/v, eprinomectin 0.4% w/v, and praziquantel 8.3% w/v (BROADLINE(®),(1) Merial) against larval and adult Aelurostrongylus abstrusus lungworms in cats was assessed in a controlled laboratory study. The
Alison Layton et al.
Journal of the American Academy of Dermatology, 69(6 Suppl 1), S57-S65 (2013-11-28)
Rosacea is a common skin disorder with multiple symptoms. The emergence of research that furthers understanding of pathophysiological mechanisms has created new targets for disease treatment. Specifically, there is a need for new treatments that address the various erythematic symptoms
Megan Brown et al.
JAMA dermatology, 150(1), 61-63 (2013-11-29)
There is a limited therapeutic armamentarium for recalcitrant cases of childhood rosacea. We report the case of a 12-year-old girl who presented with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretinoin, and topical tacrolimus. A biopsy specimen
Permethrin and ivermectin for scabies.
Bart J Currie et al.
The New England journal of medicine, 362(8), 717-725 (2010-02-26)
Frank O Richards et al.
The American journal of tropical medicine and hygiene, 89(3), 578-587 (2013-08-14)
Lymphatic filariasis (LF) in rural southeastern Nigeria is transmitted mainly by Anopheles spp. mosquitoes. Potential coinfection with Loa loa in this area has prevented use of ivermectin in the mass drug administration (MDA) strategy for LF elimination because of potential
Ivermectin (Sklice) topical lotion for head lice.
The Medical letter on drugs and therapeutics, 54(1396), 61-63 (2012-08-08)
African Programme for Onchocerciasis Control: progress report, 2013-2014.
Releve epidemiologique hebdomadaire, 89(49), 551-560 (2014-12-09)
Vitor Luís Tenório Mati et al.
The Journal of parasitology, 99(6), 1009-1018 (2013-08-06)
Abstract : Seven cases of parasitism by Strongyloides cebus were identified in Lagothrix cana from Brazil. Aspects of the clinical presentation, treatment, pathology, and parasitic biology of these infections are described. Moderate to severe disease was observed, requiring hospitalization of
Christine Baker et al.
Veterinary parasitology, 202(1-2), 54-58 (2014-04-08)
The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v) (BROADLINE(®)) was tested against adult and immature stages of Ctenocephalides felis fleas in six studies. For that purpose, fleas
Henry O D Ejere et al.
The Cochrane database of systematic reviews, 8(8), CD002219-CD002219 (2012-08-17)
It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are uncertain and data on whether the
Laura Ruykys et al.
Journal of wildlife diseases, 49(2), 312-320 (2013-04-10)
We examined the clinical and cellular effects of sarcoptic mange on southern hairy-nosed wombats (SHNW, Lasiorhinus latifrons) and the effectiveness of a single dose of ivermectin as a treatment for captive and wild animals. Wambats were caught at three sites
Dominique C Pichard et al.
Journal of the American Academy of Dermatology, 70(6), 1130-1134 (2014-05-17)
A 78-year-old Bulgarian woman presented to the National Institutes of Health (NIH) with a diagnosis of poorly differentiated metastatic carcinoma of unknown origin. The prior month she had been seen at a hospital in Bulgaria for weight loss and a
A González-Canga et al.
Current pharmaceutical biotechnology, 13(6), 924-935 (2011-11-02)
The characterisation of ivermectin pharmacokinetics can be used to predict and to ensure an optimal activity in the target species and for designing programmes aimed for parasite control. Ivermectin pharmacokinetic studies performed in several minor ruminant species are reviewed in
Martin Knaus et al.
Veterinary parasitology, 202(1-2), 45-48 (2014-04-08)
Infection with urinary capillarid bladder worms has been observed in cats worldwide. Although considered as generally causing no or little harm, infection with urinary capillarids may be associated with clinical disease which requires an appropriate treatment including the use of
Shogo Furutani et al.
Molecular pharmacology, 86(6), 686-695 (2014-09-28)
Glutamate-gated chloride channels (GluCls) mediate fast inhibitory neurotransmission in invertebrate nervous systems. Insect GluCls show alternative splicing, and, to determine its impact on channel function and pharmacology, we isolated GluCl cDNAs from larvae of the silkworm (Bombyx mori). We show
Progress towards eliminating onchocerciasis in the WHO Region of the Americas: verification by WHO of elimination of transmission in Colombia.
Releve epidemiologique hebdomadaire, 88(36), 381-385 (2013-09-24)
María-Gloria Basáñez et al.
The Lancet. Infectious diseases, 8(5), 310-322 (2008-05-13)
The broad-spectrum antiparasitic drug ivermectin was licensed for use against onchocerciasis in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and inhibition of microfilarial release by female worms remain largely
Hugo C Turner et al.
PLoS neglected tropical diseases, 7(9), e2452-e2452 (2013-09-27)
It has been proposed that switching from annual to biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci. However, historically, relatively few communities have received biannual treatments in Africa
Sébastien D S Pion et al.
PLoS neglected tropical diseases, 7(2), e2084-e2084 (2013-03-08)
Ivermectin has been the keystone of onchocerciasis control for the last 25 years. Sub-optimal responses to the drug have been reported in Ghanaian communities under long-term treatment. We assessed, in two Cameroonian foci, whether the microfilaricidal and/or embryostatic effects of
Jonathan Cotliar et al.
JAMA dermatology, 149(12), 1407-1409 (2013-10-18)
Acute graft-vs-host disease (GVHD) typically requires high-dose systemic steroids as first-line treatment. Like drug eruptions, viral exanthema, and toxic erythema of chemotherapy, Demodex folliculitis is a clinical mimicker of acute GVHD and requires nonimmunosuppressive therapy. This case of Demodex folliculitis
Recurrent angioedema associated with secondary eosinophilia.
M Cugno et al.
Journal of investigational allergology & clinical immunology, 23(2), 129-130 (2013-05-10)
Ivermectin for scabies and headlice: veterinary use only.
Mark N Lowenthal
The Israel Medical Association journal : IMAJ, 15(5), 262-262 (2013-07-12)
P González et al.
Current pharmaceutical biotechnology, 13(6), 1103-1109 (2011-11-02)
Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which
L Galvany Rossell et al.
Actas dermo-sifiliograficas, 101(1), 81-84 (2010-01-30)
Bullous scabies is a rare disease that is usually diagnosed in elderly patients. The clinical, histological, and immunological findings are identical to bullous pemphigoid. In a review of the literature, we found reports of 24 cases. We present a new
Md Musfiqur Rahman et al.
Environmental monitoring and assessment, 185(11), 9461-9469 (2013-06-05)
The pre-harvest residue limit (PHRL) of abamectin (abamectin B1a and B1b) in Perilla frutescens leaves grown under greenhouse conditions were investigated using high-performance liquid chromatography with a fluorescence detector. Samples were extracted with acetonitrile. The extract was purified through a
Wolfram Gottfried Metzger et al.
The Lancet. Infectious diseases, 14(4), 353-357 (2013-12-18)
More than 10 million people in western and central Africa are estimated to be infected with Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers a wide range of symptoms. Severe complications have been reported;
Mario A Rodríguez-Pérez et al.
PLoS neglected tropical diseases, 7(3), e2133-e2133 (2013-04-05)
The Southern Chiapas focus of onchocerciasis in Southern Mexico represents one of the major onchocerciasis foci in Latin America. All 559 endemic communities of this focus have undergone semi-annual mass treatment with ivermectin since 1998. In 50 communities of this
Aránzazu González-Canga et al.
Current drug metabolism, 10(4), 359-368 (2009-06-13)
The antiparasitic activity of ivermectin depends on the presence of an active drug concentration at the site of parasites location for an adapted length of time. Ivermectin interactions with another concurrently administered drug can occur. Concomitant administration of some drugs
Meeting of the International Task Force for Disease Eradication, January 2014.
Releve epidemiologique hebdomadaire, 89(15), 153-160 (2014-04-23)
Thorsten Althoff et al.
Nature, 512(7514), 333-337 (2014-08-22)
Cys-loop receptors are neurotransmitter-gated ion channels that are essential mediators of fast chemical neurotransmission and are associated with a large number of neurological diseases and disorders, as well as parasitic infections. Members of this ion channel superfamily mediate excitatory or
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