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Liang Luo et al.
Chemico-biological interactions, 203(2), 430-439 (2013-03-26)
Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand
Intensely pruritic eruption in a college student.
Shira Wieder et al.
JAMA, 312(14), 1458-1459 (2014-10-08)
Andy Crump et al.
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(2), 13-28 (2011-02-16)
Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin--originating solely from a single microorganism isolated at the Kitasato Institute, Tokyo, Japan from Japanese soil--has had an immeasurably beneficial impact in improving the lives and welfare of
G Molinari et al.
Cytogenetic and genome research, 128(1-3), 37-45 (2010-04-15)
Abamectin and Ivermectin are 2 closely related members of the Avermectin family of 16-membered macrocyclic lactones derived from the actinomycete Streptomyces avermectinius which exhibit extraordinary anthelmintic activity. They are used worldwide in veterinary and human medicine as well as in
J-C Makenga Bof et al.
Tropical medicine & international health : TM & IH, 20(1), 48-62 (2014-10-11)
To evaluate onchocerciasis control activities in the Democratic Republic of Congo (DRC) in the first 12 years of community-directed treatment with ivermectin (CDTI). Data from the National Programme for Onchocerciasis (NPO) provided by the National Onchocerciasis Task Force (NOTF) through the
MMWR. Morbidity and mortality weekly report, 62(14), 264-266 (2013-04-12)
Strongyloides stercoralis is an intestinal nematode endemic in the tropics and subtropics. Immunocompetent hosts typically are asymptomatic, despite chronic Strongyloides infection. In contrast, immunocompromised patients are at risk for hyperinfection syndrome and disseminated disease, with a fatality rate >50%. The
Vikas Singla
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(9), 1555-1555 (2013-05-08)
Myiasis, a term introduced by William Hope in 1840, refers to the invasion of tissues and organs of animals and human wounds and certain body cavities by the dipteran larvae, which manifests as subcutaneous furunculoid or boil-like lesions. Oral myiasis
P Lichtenberger et al.
Transplant infectious disease : an official journal of the Transplantation Society, 11(2), 137-142 (2009-01-16)
Severe strongyloidiasis, including hyperinfection and dissemination, is a recognized complication of solid organ transplantation. However, the development of strongyloidiasis in a liver transplant recipient has not been previously described. We present a case of severe strongyloidiasis occurring in a patient
Aránzazu González Canga et al.
Veterinary journal (London, England : 1997), 179(1), 25-37 (2007-09-14)
The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary
Joseph B Prullage et al.
Veterinary parasitology, 202(1-2), 30-33 (2014-04-08)
Four studies were conducted to examine the efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against Ancylostoma tubaeforme and Ancylostoma braziliense hookworms of cats. In each study, purpose-bred cats were randomly assigned to treatment
Progress towards eliminating onchocerciasis in the WHO Region of the Americas: verification by WHO of elimination of transmission in Colombia.
Releve epidemiologique hebdomadaire, 88(36), 381-385 (2013-09-24)
Md Musfiqur Rahman et al.
Environmental monitoring and assessment, 185(11), 9461-9469 (2013-06-05)
The pre-harvest residue limit (PHRL) of abamectin (abamectin B1a and B1b) in Perilla frutescens leaves grown under greenhouse conditions were investigated using high-performance liquid chromatography with a fluorescence detector. Samples were extracted with acetonitrile. The extract was purified through a
L Galvany Rossell et al.
Actas dermo-sifiliograficas, 101(1), 81-84 (2010-01-30)
Bullous scabies is a rare disease that is usually diagnosed in elderly patients. The clinical, histological, and immunological findings are identical to bullous pemphigoid. In a review of the literature, we found reports of 24 cases. We present a new
Jonathan Cotliar et al.
JAMA dermatology, 149(12), 1407-1409 (2013-10-18)
Acute graft-vs-host disease (GVHD) typically requires high-dose systemic steroids as first-line treatment. Like drug eruptions, viral exanthema, and toxic erythema of chemotherapy, Demodex folliculitis is a clinical mimicker of acute GVHD and requires nonimmunosuppressive therapy. This case of Demodex folliculitis
Sébastien D S Pion et al.
PLoS neglected tropical diseases, 7(2), e2084-e2084 (2013-03-08)
Ivermectin has been the keystone of onchocerciasis control for the last 25 years. Sub-optimal responses to the drug have been reported in Ghanaian communities under long-term treatment. We assessed, in two Cameroonian foci, whether the microfilaricidal and/or embryostatic effects of
P González et al.
Current pharmaceutical biotechnology, 13(6), 1103-1109 (2011-11-02)
Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which
Hugo C Turner et al.
PLoS neglected tropical diseases, 7(9), e2452-e2452 (2013-09-27)
It has been proposed that switching from annual to biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci. However, historically, relatively few communities have received biannual treatments in Africa
María-Gloria Basáñez et al.
The Lancet. Infectious diseases, 8(5), 310-322 (2008-05-13)
The broad-spectrum antiparasitic drug ivermectin was licensed for use against onchocerciasis in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and inhibition of microfilarial release by female worms remain largely
Recurrent angioedema associated with secondary eosinophilia.
M Cugno et al.
Journal of investigational allergology & clinical immunology, 23(2), 129-130 (2013-05-10)
S Omura
International journal of antimicrobial agents, 31(2), 91-98 (2007-11-27)
Ivermectin is a drug that many people will never have heard of. Yet thousands of villagers of all ages in communities scattered throughout the remotest parts of Africa and Latin America know its name, and some experts regard it as
Meeting of the International Task Force for Disease Eradication, January 2014.
Releve epidemiologique hebdomadaire, 89(15), 153-160 (2014-04-23)
Wolfram Gottfried Metzger et al.
The Lancet. Infectious diseases, 14(4), 353-357 (2013-12-18)
More than 10 million people in western and central Africa are estimated to be infected with Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers a wide range of symptoms. Severe complications have been reported;
Aránzazu González-Canga et al.
Current drug metabolism, 10(4), 359-368 (2009-06-13)
The antiparasitic activity of ivermectin depends on the presence of an active drug concentration at the site of parasites location for an adapted length of time. Ivermectin interactions with another concurrently administered drug can occur. Concomitant administration of some drugs
Mario A Rodríguez-Pérez et al.
PLoS neglected tropical diseases, 7(3), e2133-e2133 (2013-04-05)
The Southern Chiapas focus of onchocerciasis in Southern Mexico represents one of the major onchocerciasis foci in Latin America. All 559 endemic communities of this focus have undergone semi-annual mass treatment with ivermectin since 1998. In 50 communities of this
Thorsten Althoff et al.
Nature, 512(7514), 333-337 (2014-08-22)
Cys-loop receptors are neurotransmitter-gated ion channels that are essential mediators of fast chemical neurotransmission and are associated with a large number of neurological diseases and disorders, as well as parasitic infections. Members of this ion channel superfamily mediate excitatory or
Ivermectin for scabies and headlice: veterinary use only.
Mark N Lowenthal
The Israel Medical Association journal : IMAJ, 15(5), 262-262 (2013-07-12)
Martin Knaus et al.
Veterinary parasitology, 202(1-2), 64-68 (2014-04-08)
The efficacy of a novel topical combination of fipronil 8.3% w/v, (S)-methoprene 10% w/v, eprinomectin 0.4% w/v, and praziquantel 8.3% w/v (BROADLINE(®),(1) Merial) against larval and adult Aelurostrongylus abstrusus lungworms in cats was assessed in a controlled laboratory study. The
Alison Layton et al.
Journal of the American Academy of Dermatology, 69(6 Suppl 1), S57-S65 (2013-11-28)
Rosacea is a common skin disorder with multiple symptoms. The emergence of research that furthers understanding of pathophysiological mechanisms has created new targets for disease treatment. Specifically, there is a need for new treatments that address the various erythematic symptoms
Megan Brown et al.
JAMA dermatology, 150(1), 61-63 (2013-11-29)
There is a limited therapeutic armamentarium for recalcitrant cases of childhood rosacea. We report the case of a 12-year-old girl who presented with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretinoin, and topical tacrolimus. A biopsy specimen
Permethrin and ivermectin for scabies.
Bart J Currie et al.
The New England journal of medicine, 362(8), 717-725 (2010-02-26)
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