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Alfredo Morabia et al.
Human molecular genetics, 12(21), 2733-2743 (2003-09-11)
This study explored the genetic basis of the combination of extreme blood levels of HDL-C and LDL-C, a well-studied endophenotype for CVD, which has several attractive features as a target for genetic analysis: (1) the trait is moderately heritable; (2)
O Tiebel et al.
Human mutation, 12(3), 216-216 (2000-02-05)
Human hepatic lipase (hHL) plays an important role in hydrolysis of triglycerides from plasma lipoproteins. The enzyme also hydrolyzes HDL2 lipids resulting in smaller HDL particles with a lower cholesterol content and properties similar to HDL3. hHL is localized in
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation.
Nathalie Griffon et al.
The Journal of biological chemistry, 284(35), 23322-23330 (2009-07-02)
Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase. EL has a tropism for high density lipoprotein, and its level of
G Civallero et al.
Gene, 539(1), 154-156 (2014-02-11)
Lysosomal acid lipase (LAL) deficiency produces two well defined inborn disorders, Wolman disease (WD) and cholesteryl ester storage disease (CESD). WD is a severe, early-onset condition involving massive storage of triglycerides and cholesteryl esters in the liver, with death usually
How critical is the use of commercially available enzymes for selenium speciation?
Cuderman P and Stibilj V
Analytical and Bioanalytical Chemistry, 393(3), 1007-1013 (2009)
Ji Young Kim et al.
American journal of physiology. Endocrinology and metabolism, 291(1), E115-E127 (2006-05-18)
The minimal adipose phenotype of hormone-sensitive lipase (HSL)-null mice suggested that other hormonally responsive lipase(s) were present in adipocytes. Recent studies have characterized a new adipose tissue triglyceride lipase, ATGL/PNPLA2/destnutrin/iPLA2zeta/TTS2.2 (ATGL). We had previously cloned a novel adipose-enriched transcript by
Yuan Xie et al.
The Journal of biological chemistry, 289(11), 7994-8006 (2014-01-23)
Enzyme stability is an important issue for protein engineers. Understanding how rigidity in the active site affects protein kinetic stability will provide new insight into enzyme stabilization. In this study, we demonstrated enhanced kinetic stability of Candida antarctica lipase B
Diane Nykamp et al.
The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 28(4), 247-251 (2013-04-05)
To report a case of acute pancreatitis associated with the administration of high doses of over-the-counter (OTC) antacids containing calcium carbonate. An acute care 276-bed community hospital. In this case report, a 68-year-old male was admitted to the hospital for
M Jaye et al.
Nature genetics, 21(4), 424-428 (1999-04-07)
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation in HDL levels have not been fully
First report of telaprevir-induced pancreatitis.
Carlos Ventura et al.
Digestive diseases and sciences, 58(3), 887-888 (2013-02-09)
H van Tilbeurgh et al.
Nature, 362(6423), 814-820 (1993-04-29)
The three-dimensional structure of the lipase-procolipase complex, co-crystallized with mixed micelles of phosphatidylcholine and bile salt, has been determined at 3 A resolution by X-ray crystallography. The lid, a surface helix covering the catalytic triad of lipase, adopts a totally
Leah E Ross et al.
Biochimica et biophysica acta, 1831(6), 1052-1059 (2013-03-09)
The adsorption of colipase is essential for pancreatic triglyceride lipase activity and efficient dietary fat digestion. Yet, little is known about which specific amino acids in the hydrophobic surface of colipase influence adsorption. In this study, we systematically substituted alanine
Elena Smirnova et al.
EMBO reports, 7(1), 106-113 (2005-10-22)
Lipid droplets (LDs), also called adiposomes, are found in many eukaryotic cells, and are highly upregulated in lipid-storage cells, such as adipocytes. The mechanism by which adiposomes and their component neutral lipids are degraded is an important health issue with
Cécilia Eydoux et al.
Biochemistry, 47(36), 9553-9564 (2008-08-16)
Access to the active site of pancreatic lipase (PL) is controlled by a surface loop, the lid, which normally undergoes conformational changes only upon addition of lipids or amphiphiles. Structures of PL with their lids in the open and functional
Structure and organization of the human carboxyl ester lipase locus.
K Madeyski et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 9(4), 334-338 (1998-04-08)
John E Collins et al.
Genome biology, 5(10), R84-R84 (2004-10-06)
We have developed a systematic approach to generating cDNA clones containing full-length open reading frames (ORFs), exploiting knowledge of gene structure from genomic sequence. Each ORF was amplified by PCR from a pool of primary cDNAs, cloned and confirmed by
John E Collins et al.
Genome research, 13(1), 27-36 (2003-01-17)
We report a second-generation gene annotation of human chromosome 22. Using expressed sequence databases, comparative sequence analysis, and experimental verification, we have extended genes, fused previously fragmented structures, and identified new genes. The total length in exons of annotation was
I Dunham et al.
Nature, 402(6761), 489-495 (1999-12-11)
Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and
Boryana Todorova et al.
The Journal of clinical endocrinology and metabolism, 89(5), 2019-2023 (2004-05-06)
In population-based studies, dyslipidemia related to insulin resistance (high triglyceride level and low high-density lipoprotein cholesterol level) is a risk factor for type 2 diabetes. Therefore, variants in genes regulating lipid and lipoprotein metabolism are potential candidate genes for diabetes.
G A Martin et al.
The Journal of biological chemistry, 263(22), 10907-10914 (1988-08-05)
Hepatic triglyceride lipase (H-TGL) was isolated from human postheparin plasma by column chromatography on heparin-Sepharose and phenyl-Sepharose and immunoaffinity chromatography with monoclonal antibodies. The purified enzyme had an apparent molecular weight of 65,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and
K Hirata et al.
The Journal of biological chemistry, 274(20), 14170-14175 (1999-05-13)
A new lipoprotein lipase-like gene has been cloned from endothelial cells through a subtraction methodology aimed at characterizing genes that are expressed with in vitro differentiation of this cell type. The conceptual endothelial cell-derived lipase protein contains 500 amino acids
Akinobu Watanabe et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(7), 1513-1520 (2009-04-03)
Flutamide, an antiandrogen drug, is widely used for the treatment of prostate cancer. The initial metabolic pathways of flutamide are hydroxylation and hydrolysis. It was recently reported that the hydrolyzed product, 4-nitro-3-(trifluoromethyl)phenylamine (FLU-1), is further metabolized to N-hydroxy FLU-1, an
S Terzyan et al.
Protein science : a publication of the Protein Society, 9(9), 1783-1790 (2000-10-25)
Bile-salt activated lipase (BAL) is a pancreatic enzyme that digests a variety of lipids in the small intestine. A distinct property of BAL is its dependency on bile salts in hydrolyzing substrates of long acyl chains or bulky alcoholic motifs.
S Datta et al.
The Journal of biological chemistry, 263(3), 1107-1110 (1988-01-25)
Human hepatic lipase is an important enzyme in high density lipoprotein (HDL) metabolism, being implicated in the conversion of HDL2 to HDL3. Three human hepatic lipase cDNA clones were identified in two lambda gt11 libraries from human liver. The cDNA-derived
Mehran Howaizi et al.
Acta gastro-enterologica Belgica, 75(4), 446-447 (2013-02-14)
Acute pancreatitis has a large number of causes. Major causes are alcohol and gallstones. Toxic causes, mainly represented by medication-induced pancreatitis account for less than 2% of the cases. Cannabis is an anecdotally reported cause of acute pancreatitis. Six cases
Luigi Notari et al.
The Journal of biological chemistry, 281(49), 38022-38037 (2006-10-13)
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of
How high-density lipoprotein fuels the failing heart.
Nina Schlueter et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 955-957 (2013-03-06)
Leslie A Lange et al.
American journal of human genetics, 94(2), 233-245 (2014-02-11)
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants.
P L Pusey et al.
Phytopathology, 98(10), 1136-1143 (2008-10-24)
Pantoea agglomerans strain E325, a commercially available antagonist for fire blight of apple and pear, was originally selected through screening based on suppression of Erwinia amylovora on flower stigmas, but specific mechanisms of antagonism were unknown. Bacterial modification of pH
Maximilian Schicher et al.
Methods in molecular biology (Clifton, N.J.), 579, 497-511 (2009-09-19)
Lipases are responsible for the hydrolysis of acylglycerols and cholesteryl esters in animals, plants, and microorganisms. In this chapter we describe a tool for the concomitant analysis of lipases in complex proteomes. For this purpose, the target enzymes are selectively
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