M9546

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显示 1-30 共 578 条结果关于 "M9546" 范围论文

Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.

Soumyaditya Mula et al.

Bioorganic & medicinal chemistry, 16(6), 2932-2938 (2008-01-22)

The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher

The camelliagenin from defatted seeds of Camellia oleifera as antibiotic substitute to treat chicken against infection of Escherichia coli and Staphylococcus aureus.

Yong Ye et al.

BMC veterinary research, 11, 214-214 (2015-08-19)

Escherichia coli and Staphylococcus aureus are the main pathogens infectious to poultry, and their resistances against antibiotics have become troublesome currently. Biofilm formation is an important reason for drug resistance. Our previous research has found that the extract of Camellia

Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity.

T Narender et al.

Bioorganic & medicinal chemistry letters, 21(21), 6393-6397 (2011-09-21)

In continuation of our drug discovery program on metabolic diseases, we identified an alkaloidal amide, that is, Aegeline (V) from the plant Aegle marmelos leaves as a dual acting agent (antihyperlipidemic and antihyperglycemic). We therefore synthesized a series of alkaloidal

Well-plate freeze-drying: a high throughput platform for screening of physical properties of freeze-dried formulations.

Hjalte Trnka et al.

Pharmaceutical development and technology, 20(1), 65-73 (2014-01-15)

Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. The aim of this study was to evaluate freeze-drying in well-plates as

Interactions of corn meal or molasses with a soybean-sunflower meal mix or flaxseed meal on production, milk fatty acid composition, and nutrient utilization in dairy cows fed grass hay-based diets.

A F Brito et al.

Journal of dairy science, 98(1), 443-457 (2014-12-04)

We investigated the interactions of corn meal or molasses [nonstructural carbohydrate (NSC) supplements] with a soybean-sunflower meal mix or flaxseed meal [rumen-degradable protein (RDP) supplements] on animal production, milk fatty acids profile, and nutrient utilization in dairy cows fed grass

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Beatrice Bocca et al.

Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <

Coagulase-negative staphylococci (CoNS) isolated from ready-to-eat food of animal origin--phenotypic and genotypic antibiotic resistance.

Wioleta Chajęcka-Wierzchowska et al.

Food microbiology, 46, 222-226 (2014-12-06)

The aim of this work was to study the pheno- and genotypical antimicrobial resistance profile of coagulase negative staphylococci (CoNS) isolated from 146 ready-to-eat food of animal origin (cheeses, cured meats, sausages, smoked fishes). 58 strains were isolated, they were

Carriage of methicillin-resistant staphylococci by healthy companion animals in the US.

J A Davis et al.

Letters in applied microbiology, 59(1), 1-8 (2014-04-16)

Antimicrobial-resistant staphylococci have been associated with wounded or ill companion animals, but little is known about the prevalence of resistant staphylococci among healthy animals. In this study, 276 healthy dogs and cats from veterinary clinics were tested for the presence

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation.

Mie Kristensen et al.

The AAPS journal, 17(5), 1200-1209 (2015-05-21)

Penetratin is a widely used carrier peptide showing promising potential for mucosal delivery of therapeutic proteins. In the present study, the importance of specific penetratin residues and pH was investigated with respect to complexation with insulin and subsequent transepithelial insulin

The effect of pre-operative blood withdrawal, with or without sequestration, on allogeneic blood product requirements.

M T van der Wal et al.

Perfusion, 30(8), 643-649 (2015-02-26)

A common effect of autologous blood withdrawal before cardiopulmonary bypass (CPB) is a decrease in haematocrit (Hct) and haemoglobin (Hb) content. A refinement of this technique is autologous blood withdrawal with the sequestration of platelet rich plasma (PRP) and red

Transcellular traversal of the blood-brain barrier by the pathogenic Propionibacterium acnes.

Xuetao Lu et al.

Journal of cellular biochemistry (2018-11-30)

Propionibacterium acnes (P. acnes) is an anaerobe commonly stay in the body as part of the commensal microbiota, and a dominant bacterium of the human skin and hair follicles. It has been found that this bacterium could participate in brain

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury.

C Quoilin et al.

Biochimica et biophysica acta, 1837(10), 1790-1800 (2014-07-16)

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tubular epithelial cells exposed to a bacterial endotoxin (lipopolysaccharide, LPS). This

Presence of Pseudomonas aeruginosa influences biofilm formation and surface protein expression of Staphylococcus aureus.

Amit Kumar et al.

Environmental microbiology, 17(11), 4459-4468 (2015-05-01)

Although Staphylococcus aureus and Pseudomonas aeruginosa can individually colonize and infect their hosts, the commensalistic effect of the two is more tenacious and lethal. In this study, it was shown that in co-culture with P. aeruginosa, a sub-population of S. aureus exhibited

Determinants of intestinal permeability in healthy first-degree relatives of individuals with Crohn's disease.

David Kevans et al.

Inflammatory bowel diseases, 21(4), 879-887 (2015-03-04)

The Genetics, Environmental, Microbial Project is a multicenter study assessing etiological factors in Crohn's disease by studying healthy first-degree relatives (FDRs) of individuals affected by Crohn's disease. We aimed to evaluate the contribution of genetic, microbial, and environmental factors to

Molecular analysis and susceptibility pattern of meticillin-resistant Staphylococcus aureus strains in emergency department patients and related risk factors in Iran.

M Rezaei et al.

The Journal of hospital infection, 89(3), 186-191 (2015-01-27)

Meticillin-resistant Staphylococcus aureus (MRSA) has become widespread in the hospital and in the community. Nasal colonization with MRSA has been identified as a risk factor for MRSA infection. To determine the prevalence of nasal colonization with MRSA among adult patients

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.

D J Naisbitt et al.

AIDS research and human retroviruses, 16(18), 1929-1938 (2001-01-12)

The aim of these studies was to determine whether HIV-infected patients have a plasma thiol deficiency and whether this is associated with decreased detoxification of the toxic metabolites of sulfamethoxazole. Reduced, oxidized, protein-bound, and total thiol levels were measured in

Influence of environmental hypertonicity on the induction of ureogenesis and amino acid metabolism in air-breathing walking catfish (Clarias batrachus, Bloch).

Bodhisattwa Banerjee et al.

Indian journal of experimental biology, 52(7), 728-738 (2014-07-26)

Effect of environmental hypertonicity, due to exposure to 300 mM mannitol solution for 7 days, on the induction of ureogenesis and also on amino acid metabolism was studied in the air-breathing walking catfish, C. batrachus, which is already known to

The role of fillers and sodium metabisulfite on drug release from aged polyox tablets.

Saeed Shojaee et al.

Drug development and industrial pharmacy, 40(11), 1451-1458 (2013-08-22)

Polyethylene oxides (PEOs) are extensively used to control the release rate of drugs from matrices. Unfortunately, polyox polymers are prone to oxidation under high temperature and relative humidity. The aim of this study was to investigate the effect of sodium

Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas.

Norisuke Shibuya et al.

Oncology, 88(5), 309-319 (2015-01-17)

Glycolysis and the pentose phosphate pathway (PPP) are preferentially activated in cancer cells. Accumulating evidence indicated the significance of the altered glucose metabolism in cancer, but the implication for oncotherapy remains unclear. Here we report that the synthesis of glycolytic

Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability.

Shmuel Hess et al.

Journal of medicinal chemistry, 50(24), 6201-6211 (2007-11-07)

A library of 18 hexapeptide analogs was synthesized, including sub-libraries of N- or C-methylation of the parent hexapeptide Phe-Gly-Gly-Gly-Gly-Phe, as well as backbone cyclized analogs of each linear analog with various ring sizes. N- or C-methylation as well as cyclization

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1.

Adam H Kramer et al.

Journal of cellular biochemistry, 116(7), 1232-1240 (2015-01-08)

A mechanistic relationship exists between protein localisation, activity and cellular differentiation. Understanding the contribution of these molecular mechanisms is required for elucidation of conditions that drive development. Literature suggests non-canonical translocation of the Signal Transducer and Activator of Transcription 3

Accuracy of eucapnic hyperpnea or mannitol to diagnose exercise-induced bronchoconstriction: a systematic review.

Michael K Stickland et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107(3), 229-234 (2011-08-31)

Exercise challenge testing is the typical method for diagnosing exercise induced bronchoconstriction; however, alternate tests have been developed. The purpose of this paper was to summarize the current literature comparing eucapnic voluntary hyperpnea and mannitol with standard exercise challenge testing

Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids.

Sarah Kolitz et al.

Scientific reports, 5, 10191-10191 (2015-05-23)

Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action remains to be fully elucidated, and no validated pharmacokinetic or pharmacodynamic biomarkers

Inaccuracy of fluid container volume markings.

R W A Nowicki

Anaesthesia, 68(6), 651-651 (2013-05-15)

Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation.

Susana Rodrigues et al.

Carbohydrate polymers, 123, 369-380 (2015-04-07)

Chitosan/carrageenan/tripolyphosphate nanoparticles were previously presented as holding potential for an application in transmucosal delivery of macromolecules, with tripolyphosphate demonstrating to contribute for both size reduction and stabilisation of the nanoparticles. This work was aimed at evaluating the capacity of the

Low concentrations of the toxin ophiobolin A lead to an arrest of the cell cycle and alter the intracellular partitioning of glutathione between the nuclei and cytoplasm.

Vittoria Locato et al.

Journal of experimental botany, 66(10), 2991-3000 (2015-04-22)

Ophiobolin A, a tetracyclic sesterpenoid produced by phytopathogenic fungi, is responsible for catastrophic losses in crop yield but its mechanism of action is not understood. The effects of ophiobolin A were therefore investigated on the growth and redox metabolism of

Synthesis, characterization, antioxidant activity and DNA-binding studies of two rare earth(III) complexes with naringenin-2-hydroxy benzoyl hydrazone ligand.

Tian-Rong Li et al.

European journal of medicinal chemistry, 43(8), 1688-1695 (2007-11-27)

Two novel rare earth complexes, Y(III) complex (1) and Eu(III) complex (2), with naringenin-2-hydroxy benzoyl hydrazone ligand were synthesized and characterized. The interaction of the two metal complexes and the free ligand with calf thymus DNA (CT DNA) was investigated

Mad2 checkpoint gene silencing using epidermal growth factor receptor-targeted chitosan nanoparticles in non-small cell lung cancer model.

Ana Vanessa Nascimento et al.

Molecular pharmaceutics, 11(10), 3515-3527 (2014-09-27)

RNA interference has emerged as a powerful strategy in cancer therapy because it allows silencing of specific genes associated with tumor progression and resistance. Mad2 is an essential mitotic checkpoint component required for accurate chromosome segregation during mitosis, and its

Tuning aerosol performance using the multibreath Orbital® dry powder inhaler device: controlling delivery parameters and aerosol performance via modification of puck orifice geometry.

Bing Zhu et al.

Journal of pharmaceutical sciences, 104(7), 2169-2176 (2015-05-02)

The current study presents a new approach to tackle high-dose lung delivery using a prototype multibreath Orbital® dry powder inhaler (DPI). One of the key device components is the "puck" (aerosol sample chamber) with precision-engineered outlet orifice(s) that control the

Traumatic intracranial hypertension.

Nino Stocchetti et al.

The New England journal of medicine, 370(22), 2121-2130 (2014-05-30)

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