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Monique P Curran et al.
Drugs, 64(17), 1915-1919 (2004-08-27)
A combination package containing delayed-release capsules of the proton pump inhibitor lansoprazole (15 mg once daily) and tablets of the NSAID naproxen (375 or 500 mg twice daily) has been approved for reducing the risk of NSAID-associated gastric ulcers in
Hanxia Liu et al.
Journal of nanoscience and nanotechnology, 14(7), 4837-4842 (2014-04-25)
A photocleavable nitrobenzyl ester group was introduced in the backbone of self-assembling peptides using standard Fmoc-peptide systhesis. The nitrobenzyl ester group could be used as a cleavable linker to connect a gelator and a hydrophilic group. Photo-irradiation would lead to
E Mikami et al.
Journal of pharmaceutical and biomedical analysis, 23(5), 917-925 (2000-10-07)
A high-performance liquid chromatographic (HPLC) method for simultaneous determination of naproxen (NAP), nabumetone (NAB) and its major metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), was developed for the application to pharmaceuticals and human urine. Isocratic reversed-phase HPLC was employed for quantitative analysis using
Renan O Silva et al.
Marine drugs, 10(12), 2618-2633 (2013-01-25)
Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised of substances with pharmaceutical and biomedical potential. The aim of the present study was to evaluate the protective effect of the PLS fraction extracted
Catalina Cleves et al.
Expert review of neurotherapeutics, 8(9), 1289-1297 (2008-09-02)
Sumatriptan 85 mg with naproxen sodium 500 mg, a combination tablet for the acute treatment of migraine, is approved in the USA. It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data are on
Drugs in R&D, 8(4), 255-258 (2007-06-29)
Naproxcinod is a derivative of naproxen with similar anti-inflammatory activity, but less gastrointestinal toxicity. It is the first of a new class of analgesic and anti-inflammatory drugs known as cyclo-oxygenase-(COX)-inhibiting nitric oxide donators (CINODs) under development with NicOx in several
Recurrent angioedema after naproxen use in a patient stabilized with losartan.
Jineane V Venci et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(6), 666-667 (2014-10-06)
Simon Law et al.
The Cochrane database of systematic reviews, 10(10), CD009455-CD009455 (2013-10-22)
Migraine is a common, disabling condition and a burden for the individual, health services, and society. Many sufferers choose not to, or are unable to, seek professional help and rely on over-the-counter analgesics. Naproxen is a non-steroidal anti-inflammatory drug (NSAID);
Jiayang Li et al.
Journal of the American Chemical Society, 135(2), 542-545 (2012-11-10)
As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. Thus, it is beneficial to develop topical gels that selectively inhibit cyclooxygenase-2
K Nezvalová-Henriksen et al.
BJOG : an international journal of obstetrics and gynaecology, 120(8), 948-959 (2013-03-16)
To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome. Cohort study. Norwegian population. A total of 90 417 women and singleton child pairs. The Norwegian Mother and Child Cohort Study and Medical Birth Registry of
Dong Qing Zhang et al.
Chemosphere, 91(1), 14-21 (2012-12-27)
Scirpus validus was grown hydroponically and exposed to the pharmaceuticals, carbamazepine and naproxen at concentrations of 0.5-2.0 mg L(-1) for an exposure duration of up to 21 d. By the end of experiment, carbamazepine elimination from the nutrient solution reached
The concept of axial spondyloarthritis. Lessons from the INFAST study.
Henning Zeidler
Annals of the rheumatic diseases, 73(4), e18-e18 (2013-12-10)
J Rossat et al.
Clinical pharmacology and therapeutics, 66(1), 76-84 (1999-08-03)
To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) to those of naproxen, a nonselective inhibitor of cyclooxygenases in salt-depleted subjects. Forty subjects were randomized into four parallel groups to receive 200 mg
Christopher Lockhart et al.
Biophysical journal, 103(11), 2341-2351 (2013-01-04)
All-atom explicit solvent model and replica exchange molecular dynamics were used to investigate binding of Alzheimer's biomarker FDDNP to the Aβ(10-40) monomer. At low and high concentrations, FDDNP binds with high affinity to two sites in the Aβ(10-40) monomer located
Michela Campolo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4489-4499 (2013-08-01)
Spinal cord trauma causes loss of motor function that is in part due to the ensuing inflammatory response. Hydrogen sulfide (H2S) is a potent, endogenous anti-inflammatory and neuroprotective substance that has been explored for use in the design of novel
Qing Zhu et al.
The journal of physical chemistry. B, 117(5), 1494-1500 (2013-01-17)
The crystallization kinetics of naproxen (NAP) in NAP/polyethylene glycol (NAP/PEG) solid dispersions prepared at different crystallization temperatures was studied by in situ small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS). It was found that the crystallization rate of NAP was faster at
Jenny-Maria Brozinski et al.
Environmental science & technology, 47(1), 342-348 (2012-11-29)
Pharmaceutical residues are ubiquitous in rivers, lakes, and at coastal waters affected by discharges from municipal wastewater treatment plants. In this study, the presence of 17 different pharmaceuticals and six different phase I metabolites was determined in the bile of
J Sieper et al.
Annals of the rheumatic diseases, 73(1), 101-107 (2013-05-23)
To assess whether combination therapy with infliximab (IFX) plus nonsteroidal anti-inflammatory drugs (NSAIDs) is superior to NSAID monotherapy for reaching Assessment of SpondyloArthritis international Society (ASAS) partial remission in patients with early, active axial spondyloarthritis (SpA) who were naïve to
H Jick et al.
Pharmacotherapy, 13(3), 212-217 (1993-05-01)
We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed
J I Schwartz et al.
Clinical pharmacology and therapeutics, 72(1), 50-61 (2002-08-02)
This study compared directly the renal effects of two selective cyclooxygenase (COX)-2 inhibitors (rofecoxib and celecoxib) with naproxen (dual COX-1/COX-2 inhibitor) and placebo in healthy elderly subjects on a sodium-replete diet. A total of 67 elderly subjects stabilized in the
A D Rodrigues et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(1), 126-136 (1996-01-01)
Cytochrome P450 (CYP) activity in human liver microsomes was measured after the O-demethylation of [O-methyl 14C]naproxen (NAPase). The formation of [14C]formaldehyde in the presence of microsomes was described by an apparent KM(1) and Vmax(1) of 0.16 +/- 0.09 mM and
Fahimeh Kamarei et al.
Journal of chromatography. A, 1308, 132-138 (2013-08-21)
This paper compares two methods used for the preparative purification of a mixture of (S)-, and (R)-naproxen on a Whelk-O1 column, using either high performance liquid chromatography or supercritical fluid chromatography. The adsorption properties of both enantiomers were measured by
Pain relievers: bad for your heart? People with heart disease should avoid prolonged use of certain anti-inflammatory drugs, Naproxen (Aleve) is safest.
Harvard men's health watch, 17(6), 3-3 (2013-07-04)
Raveendhara R Bannuru et al.
Annals of internal medicine, 162(1), 46-54 (2015-01-07)
The relative efficacy of available treatments of knee osteoarthritis (OA) must be determined for rational treatment algorithms to be formulated. To examine the efficacy of treatments of primary knee OA using a network meta-analysis design, which estimates relative effects of
Simon Law et al.
The Cochrane database of systematic reviews, 10(10), CD008541-CD008541 (2013-10-22)
Migraine is a common disabling condition and a burden for the individual, health services, and society. Effective abortive treatments include the triptan and non-steroidal anti-inflammatory classes of drugs. These drugs have different mechanisms of action and combining them may provide
L K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 193, 29-36 (2014-07-06)
Pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) enter the soil environment via irrigation with treated wastewater, groundwater recharge, and land application of biosolids. The transformation and fate of PPCP/EDCs in soil affects their potential for plant
Theodore M Brasky et al.
International journal of cancer, 135(8), 1869-1883 (2014-03-07)
The use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risks of cancers at several sites in some studies; however, we recently reported no association between their use and total cancer risk in women in a prospective study.
E Ozkaya-Bayazit
Clinical and experimental dermatology, 29(4), 419-422 (2004-07-13)
The aim of this study was to investigate the usefulness of topical provocation in the diagnosis of metamizol- and naproxen-induced fixed drug eruption (FDE). Five patients with metamizol- and four patients with naproxen-induced FDE established by oral provocation were tested
Kobra Sadat Hasheminasab et al.
Journal of chromatography. A, 1285, 1-6 (2013-03-12)
A new design of low voltage electromembrane extraction (EME) using carbon nanotube reinforced hollow fiber was developed for the determination of acidic drugs in biological and wastewater samples. The supported liquid membrane (SLM) with carbon nanotubes as the sorbent interface
Naproxen sodium/metoclopramide: metoclopramide/naproxen-sodium, MT 100, naproxen-sodium/metoclopramide.
Drugs in R&D, 7(4), 259-261 (2006-06-21)
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