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The peeling dermatitis with a peculiar demarcation.
Tai-Heng Chen et al.
The American journal of the medical sciences, 346(5), 421-421 (2012-11-02)
U Julius et al.
Atherosclerosis. Supplements, 14(1), 7-13 (2013-01-30)
Nicotinic acid has complex effects on lipoprotein metabolism; it increases HDL cholesterol, decreases triglycerides and LDL cholesterol. It also reduces lipoprotein(a) levels by about 25% and exerts certain effects that may be antiatherogenic. Studies performed in the pre-statin era demonstrated
Da Li et al.
The British journal of nutrition, 110(12), 2156-2164 (2013-06-19)
Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity and type 2 diabetes, both of which are associated with insulin resistance and epigenetic changes. The purpose of the present study
Tobias Kroon et al.
Journal of lipid research, 56(9), 1679-1690 (2015-07-15)
Acute nicotinic acid (NiAc) administration results in rapid reduction of plasma FFA concentrations. However, sustained NiAc exposure is associated with tolerance development resulting in return of FFA to pretreatment levels. The aim of this study was to determine whether a
Subharekha Raghavan et al.
Bioorganic & medicinal chemistry letters, 18(11), 3163-3167 (2008-05-15)
The design, synthesis, and biological activity of a series of cycloalkene acid-based niacin receptor agonists are described. This led to the discovery that tetrahydro anthranilic acid is an excellent surrogate for anthranilic acid. Several compounds were identified that were potent
Julia C Creider et al.
Nature reviews. Endocrinology, 8(9), 517-528 (2012-02-22)
Niacin, or water-soluble vitamin B(3), when given at pharmacologic doses, is a powerful lipid-altering agent. This drug, which lowers the levels of atherogenic, apolipoprotein-B-containing lipoproteins, is one of few medications that can raise the levels of atheroprotective HDL cholesterol. Niacin
Frank Preugschat et al.
Archives of biochemistry and biophysics, 564, 156-163 (2014-09-25)
hCD157 catalyzes the hydrolysis of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The release of nicotinamide or nicotinic acid from NR or NAR was confirmed by spectrophotometric, HPLC and NMR analyses. hCD157 is inactivated by a mechanism-based inhibitor, 2'-deoxy-2'-fluoro-nicotinamide
Takeki Uehara et al.
Molecular nutrition & food research, 54(2), 218-227 (2009-12-31)
Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to
Umi Fahmida et al.
Food and nutrition bulletin, 35(4 Suppl), S174-S179 (2015-02-03)
Affordable, locally contextual complementary feeding recommendations (CFRs) that take into account cultural diversity and differences in food availability will be more likely to result in long-term improvements in complementary feeding practices than general recommendations. More objective approaches, such as linear
Hua Huang et al.
PloS one, 9(12), e114643-e114643 (2014-12-19)
Niacin reduces vascular oxidative stress and down regulates inducible nitric oxide synthase, an enzyme mediating proatherosclerotic effects in part by increasing oxidative stress. Here, we evaluate whether Niacin reverses the redox sensitive migratory arrest of macrophages in response to oxidised(ox)
Niacin for reduction of cardiovascular risk.
Inge A M van den Oever et al.
The New England journal of medicine, 371(20), 1942-1942 (2014-11-13)
Daisuke Yasuda et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2412-2422 (2015-02-19)
Asparagine-linked glycosylation (N-glycosylation) is necessary for the proper folding of secreted and membrane proteins, including GPCRs. Thus, many GPCRs possess the N-glycosylation motif Asn-X-Ser/Thr at their N-termini and/or extracellular loops. We found that human GPR109A (hGPR109A) has an N-glycosylation site
Baiba K Gillard et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(7), 1714-1721 (2013-05-04)
HIV patients on antiretroviral therapy (HIV/ART) exhibit a unique atherogenic dyslipidemic profile with hypertriglyceridemia (HTG) and low plasma concentrations of high-density lipoprotein (HDL) cholesterol. In the Heart Positive Study of HIV/ART patients, a hypolipidemic therapy of fenofibrate, niacin, diet, and
Johanna Mock et al.
Journal of bacteriology, 197(18), 2965-2980 (2015-07-08)
Most acetogens can reduce CO2 with H2 to acetic acid via the Wood-Ljungdahl pathway, in which the ATP required for formate activation is regenerated in the acetate kinase reaction. However, a few acetogens, such as Clostridium autoethanogenum, Clostridium ljungdahlii, and
Matilda Florentin et al.
Current vascular pharmacology, 9(4), 385-400 (2011-02-15)
Treatment with statins has significantly reduced cardiovascular morbidity and mortality, an effect attributed to both the low-density lipoprotein cholesterol (LDL-C) lowering capacity and the pleiotropic actions of these drugs. However, residual risk remains even after intense LDL-C lowering. Therefore, additional
James M Backes et al.
Postgraduate medicine, 123(2), 70-83 (2011-04-09)
Niacin is a water-soluble B vitamin (B3) known to have favorable effects on multiple lipid parameters, including raising high-density lipoprotein cholesterol (HDL-C) levels and lowering triglycerides (TGs), lipoprotein(a), and low-density lipoprotein cholesterol (LDL-C). Although LDL-C remains the primary target of
Bertrand Lebouché et al.
Trials, 15, 390-390 (2014-10-09)
Approximately 30% of HIV-1-infected patients receiving antiretroviral therapy who achieve virologic control have unsatisfactory immune reconstitution, with CD4+ T-cell counts persistently below 350 cells/μL. These patients are at elevated risk for clinical progression to AIDS and non-AIDS events. CD4+ T-cell
Lucia Carrano et al.
BioMed research international, 2015, 419383-419383 (2015-09-09)
With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules. They are ribosomally synthetized and posttranslationally modified peptides possessing potent antimicrobial activity against aerobic and anaerobic Gram-positive pathogens
Patricia Alvarez-Sieiro et al.
Food chemistry, 168, 439-444 (2014-08-31)
For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrogen, was developed for screening for microorganisms with gliadinase
Role of nicotinic Acid in atherosclerosis prevention-reply.
Cynthia A Jackevicius et al.
JAMA internal medicine, 174(4), 649-649 (2014-04-09)
Amanda Rennick et al.
Pharmacotherapy, 33(6), 683-690 (2013-03-26)
Phosphate binders have traditionally been used to treat hyperphosphatemia, a common complication in patients with end stage renal disease (ESRD). New evidence suggests that nicotinic acid and its metabolites may effectively decrease phosphorus absorption in the gastrointestinal tract, thereby reducing
J Sirc et al.
Physiological research, 64 Suppl 1, S51-S60 (2015-10-09)
Hyperlipidemia treatment based on niacin requires gastrointestinal administration of relatively high doses. The recommended dietary allowance of niacin as vitamin B3 is 14 to 16 mg daily in adults, while the doses of niacin used in the treatment of hyperlipidemia
Katrina L Bogan et al.
Annual review of nutrition, 28, 115-130 (2008-04-24)
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates
Janet E Digby et al.
Current opinion in lipidology, 20(4), 321-326 (2009-06-06)
Nicotinic acid is the most potent treatment clinically available for lowering LDL cholesterol and VLDL cholesterol and raising HDL cholesterol. The strong inverse relationship between coronary heart disease risk and HDL cholesterol at all levels of LDL cholesterol has, therefore
Jason E Imbriglio et al.
Bioorganic & medicinal chemistry letters, 19(8), 2121-2124 (2009-03-25)
5-Alkyl and aryl-pyrazole-tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Sudhir Chowdhry et al.
Nature, 569(7757), 570-575 (2019-04-26)
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs1; however, targeting the frequently dysregulated metabolic landscape of cancer has proven to be a major challenge2. Here we show that tissue context is the major determinant of dependence on
Jae-Kyu Jung et al.
Journal of medicinal chemistry, 50(7), 1445-1448 (2007-03-16)
Recently identified GPCRs, GPR109a and GPR109b, the high and low affinity receptors for niacin, may represent good targets for the development of HDL elevating drugs for the treatment of atherosclerosis. Acifran, an agonist of both receptors, has been tested in
Vaijinath S Kamanna et al.
Current opinion in lipidology, 24(3), 239-245 (2013-04-27)
This review focuses on the current understanding of the physiological mechanisms of action of niacin on lipid metabolism and atherosclerosis. Emerging findings indicate that niacin decreases hepatic triglyceride synthesis and subsequent VLDL/LDL secretion by directly and noncompetitively inhibiting hepatocyte diacylglycerol
Rachel L Edwards et al.
Infection and immunity, 81(3), 945-955 (2013-01-16)
In response to environmental fluctuations or stresses, bacteria can activate transcriptional and phenotypic programs to coordinate an adaptive response. The intracellular pathogen Legionella pneumophila converts from a noninfectious replicative form to an infectious transmissive form when the bacterium encounters alterations
Ioanna Gouni-Berthold et al.
Current pharmaceutical design, 19(17), 3094-3106 (2013-01-16)
The clinically most relevant medications for lipid management are the statins, which constitute in the majority of the cases the basis of any lipid-modulating therapy. However, other agents are often needed to either reduce low-density cholesterol to target levels and/or
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