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- GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
Bioorganic & medicinal chemistry letters (2009-03-25)
Jason E Imbriglio, Sookhee Chang, Rui Liang, Subharekha Raghavan, Darby Schmidt, Abby Smenton, Scott Tria, Thomas O Schrader, Jae-Kyu Jung, Craig Esser, Andrew K P Taggart, Kang Cheng, Ester Carballo-Jane, M Gerard Waters, James R Tata, Steven L Colletti
PMID19307116
摘要
5-Alkyl and aryl-pyrazole-tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.