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显示 1-30 共 85 条结果 关于 "P-916" 范围 论文
Michael F Grunebaum et al.
The Journal of clinical psychiatry, 74(9), 872-879 (2013-10-11)
Identifying the depression symptoms most closely associated with suicidal thoughts and which medications provide the fastest depression relief may help suicide prevention. Post hoc analysis of data from a randomized, double-blind, 8-week clinical trial of the selective serotonin reuptake inhibitor
Gordana Ristevska-Dimitrovska et al.
Psychiatria Danubina, 25(2), 123-127 (2013-06-26)
A growing body of evidence shows that brain-derived neurotrophic factor (BDNF) plays a role in depressive disorder. Serum BDNF levels are lower in depressed patients and they increase after a long course of antidepressant treatment. Our study aims to test
Steven G Potkin et al.
Journal of clinical psychopharmacology, 33(1), 3-10 (2013-01-02)
The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-label, multicenter study. QT interval prolongation by medications, including both conventional and
[Posttraumatic stress disorder].
Ruth V Reed et al.
Praxis, 102(1), 45-48 (2013-02-07)
Harry G Brittain
Profiles of drug substances, excipients, and related methodology, 38, 407-421 (2013-05-15)
The polymorphic (crystal systems for which a substance can exist in structures defined by different unit cells, and where each of the forms has the same elemental composition) and solvatomorphic (systems where the crystal structures of the substance are defined
Putting GlaxoSmithKline to the test over paroxetine.
Peter Doshi
BMJ (Clinical research ed.), 347, f6754-f6754 (2013-11-14)
Neelesh Malviya et al.
Acta poloniae pharmaceutica, 70(2), 317-322 (2013-04-26)
The present study aimed to investigate the effect of ethyl acetate fraction of A. cepa bulb on mating behavior in paroxetine-induced sexually dysfunction male rats. Sexual dysfunctions such as decreased libido, delayed orgasm, difficulties in maintaining an erection, and inhibition
M A Sierra-Rodriguez et al.
Seminars in ophthalmology, 28(4), 244-246 (2013-05-01)
To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma. Case report. A 33-year-old women who had been under paroxetine treatment for the past four months presented
Paroxetine approval.
Suzanne M Mahon et al.
The American journal of nursing, 114(1), 10-10 (2013-12-29)
Joannie Poirier-Bisson et al.
The Journal of nervous and mental disease, 201(9), 753-759 (2013-09-03)
The aim of this study was to assess the incremental cost-effectiveness ratios (ICERs) of two brief cognitive-behavioral therapy (CBT)-based interventions and a pharmacological treatment, compared with usual care, initiated in the emergency department (ED) for individuals with panic disorder (PD)
Mohamed A El-Nabarawi et al.
International journal of pharmaceutics, 443(1-2), 307-317 (2013-01-23)
Paroxetine (PAX) is the most potent serotonin reuptake blocker antidepressant clinically available. This study is aimed to reduce the side effects accompanied with the initial high plasma concentration after oral administration of PAX and fluctuations in plasma levels and also
N Byatt et al.
Acta psychiatrica Scandinavica, 127(2), 94-114 (2012-12-18)
Conflicting data have led to controversy regarding antidepressant use during pregnancy. The objectives of this study are to i) review the risks of untreated depression and anxiety, ii) review the literature on risks of exposure to antidepressants during pregnancy, iii)
David Germann et al.
Profiles of drug substances, excipients, and related methodology, 38, 367-406 (2013-05-15)
Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. Paroxetine is indicated for the treatment of depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and social anxiety disorder. The physicochemical
Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?
Stephen B Wheatcroft
Diabetes, 62(3), 698-700 (2013-02-23)
Roi Isaac et al.
The Journal of biological chemistry, 288(8), 5682-5693 (2013-01-01)
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants used for the treatment of mood and anxiety disorders. Here, we demonstrate that incubation (2 h) of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced
Serotonin and yawning: A possible adverse drug reaction during antidepressant therapy.
Johana Béné et al.
Presse medicale (Paris, France : 1983), 43(10 Pt 1), 1135-1136 (2014-05-06)
Sebastian H Scharf et al.
Neuropharmacology, 72, 38-46 (2013-04-23)
Exposure to chronic stress during developmental periods is a risk factor for a number of psychiatric disorders. While the direct effects of stress exposure have been studied extensively, little is known about the long-lasting effects and the interaction with ageing.
Claudia Schilling et al.
Journal of clinical psychopharmacology, 33(1), 99-103 (2013-01-02)
Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with amitriptyline or paroxetine, as
FDA approval of paroxetine for menopausal hot flushes.
Ronald J Orleans et al.
The New England journal of medicine, 370(19), 1777-1779 (2014-05-09)
Yukiko Mine et al.
Journal of pharmacological sciences, 121(1), 58-66 (2012-12-22)
Although selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, they frequently cause gastrointestinal adverse effects, such as nausea and emesis. In the present study, we investigated the anti-emetic effect of mosapride, a 5-HT(4) receptor agonist, on SSRIs-induced
Akiko Mikami et al.
International journal of clinical pharmacology and therapeutics, 51(5), 374-382 (2013-01-30)
To develop a pharmacokinetic model able to describe the nonlinear pharmacokinetics of paroxetine (PRX) and to predict the drug-drug interaction between PRX and metoprolol under various dosage regimens. A pharmacokinetic model of PRX incorporating mechanism-based inhibition was developed. This model
Manish B Shah et al.
The Journal of pharmacology and experimental therapeutics, 346(1), 113-120 (2013-05-02)
An X-ray crystal structure of CYP2B4 in complex with the drug paroxetine [(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine] was solved at 2.14 Å resolution. The structure revealed a conformation intermediate to that of the recently solved complex with amlodipine and that of the more compact
Adam S Kamlet et al.
PloS one, 8(3), e59187-e59187 (2013-04-05)
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to
Neil M Davies et al.
Journal of clinical epidemiology, 66(12), 1386-1396 (2013-10-01)
To investigate whether physicians' prescribing preferences were valid instrumental variables for the antidepressant prescriptions they issued to their patients. We investigated whether physicians' previous prescriptions of (1) tricyclic antidepressants (TCAs) vs. selective serotonin reuptake inhibitors (SSRIs) and (2) paroxetine vs.
5-HTTLPR rs25531A > G differentially influence paroxetine and fluvoxamine antidepressant efficacy: a randomized, controlled trial.
Masaki Kato et al.
Journal of clinical psychopharmacology, 33(1), 131-132 (2013-01-05)
Clare M Mathes et al.
Chemical senses, 38(3), 211-220 (2012-12-21)
Increased serotonergic activity has been shown to reduce motivation to ingest, which may involve, in part, gustatory processes. Here, we examined the effect of paroxetine, a selective serotonin reuptake inhibitor, on appetitive responding for a preferred and an avoided taste
Paroxetine (Brisdelle) for hot flashes.
The Medical letter on drugs and therapeutics, 55(1428), 85-86 (2013-10-30)
Miguel M Carvalho et al.
Molecular neurodegeneration, 8, 14-14 (2013-04-30)
Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence
Wojciech Waldman et al.
Przeglad lekarski, 69(8), 587-588 (2012-12-19)
Hydroxycarbamide (HCB), also known as hydroxyurea, is an urea derivative used mainly as antineoplastic and antisickling agent. We described a 31 yrs. female, with essential thrombocythemia, who was admitted to our clinic because of double suicidal ingestion of hydroxycarbamide. First
Kristoff T Homan et al.
Molecular pharmacology, 85(2), 237-248 (2013-11-14)
Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. Paroxetine exhibits up to 50-fold selectivity for GRK2 versus other GRKs. A better understanding of
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