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Peter Dan Broulík et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(9), 1166-1169 (2013-07-09)
Intake of multivitamin preparations is very common in developed countries. However, excessive intake of vitamin A was associated with increased bone fragility. The aim of this study was to determine if chronic administration of the active metabolite of vitamin A
Mikio Kawamura et al.
Anticancer research, 34(7), 3425-3429 (2014-07-02)
The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and
A TaqI site identifies the *A allele at the ACP1 locus.
G F Sensabaugh et al.
Human molecular genetics, 2(7), 1079-1079 (1993-07-01)
Koichiro Komatsu et al.
The Journal of endocrinology, 219(2), 145-158 (2013-10-08)
Bisphosphonates (BPs) are a major class of antiresorptive drug, and their molecular mechanisms of antiresorptive action have been extensively studied. Recent studies have suggested that BPs target bone-forming cells as well as bone-resorbing cells. We previously demonstrated that local application
Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.
Aupperlee MD, Zhao Y, Tan YS, et al.
Endocrinology, 155(6), 2301-2313 (2014)
P Tailor et al.
The Journal of biological chemistry, 272(9), 5371-5374 (1997-02-28)
Activation of resting T lymphocytes is initiated by rapid but transient tyrosine phosphorylation of a number of cellular proteins. Several protein tyrosine kinases and protein tyrosine phosphatases are known to be important for this response. Here we report that normal
J J Stĕpán et al.
Biochemical and biophysical research communications, 165(3), 1027-1034 (1989-12-29)
Tartrate-resistant acid phosphatases types 5a and 5b were purified from human hairy cell leukemia spleen by sequential chromatography on Phenyl-Sepharose, CM-Sepharose, concanavalin A-Sepharose, FPLC Superose-12 and FPLC Mono-S. The purification over the original tissue extract was 1150- and 3300-fold, with
R F Viecilli et al.
Journal of dental research, 92(4), 346-351 (2013-02-28)
Optimum stresses for a favorable response to orthodontics are still unknown. Here, we compared the effects of initial periodontal ligament (PDL) stresses over time in orthodontic external root resorption (OERR), necrosis, and the TRAP+ cell population. Forty-two rats (Fischer CDF)
D K Lord et al.
European journal of biochemistry, 189(2), 287-293 (1990-04-30)
The purple acid phosphatases and uteroferrin belong to a diverse multifunctional class of binuclear iron-containing proteins that includes haemerythrin and ribonucleotide reductase. In the pig, uteroferrin has been implicated in the delivery of iron to the foetus, but the role
Noriyuki Okonogi et al.
International journal of radiation oncology, biology, physics, 87(5), 968-974 (2013-10-22)
To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without
Ilona Hauber et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(22), 9033-9038 (2009-05-20)
Peptide fragments, derived from prostatic acidic phosphatase, are secreted in large amounts into human semen and form amyloid fibrils. These fibrillar structures, termed semen-derived enhancer of virus infection (SEVI), capture HIV virions and direct them to target cells. Thus, SEVI
Ian R Johnson et al.
The Prostate, 74(5), 547-560 (2014-01-18)
Prostate cancer cell lines have been used in the search for biomarkers that are suitable for prostate cancer diagnosis. Unfortunately, many cell line studies have only involved single cell lines, partially characterized cell lines or were performed without controls, and
Marta Ferreira Bastos et al.
The International journal of oral & maxillofacial implants, 29(1), 221-231 (2014-01-24)
To evaluate the effects of caffeine and/or estrogen deficiency on trabecular bone area (TBA) and bone healing in rats. Rats were divided into groups (n=15/group) as follows: control, caffeine, ovariectomy (OVX), and caffeine/OVX. Critical-sized defects were created in the tibiae
Y Y Wo et al.
The Journal of biological chemistry, 267(15), 10856-10865 (1992-05-25)
Low molecular weight phosphotyrosyl protein phosphatases of human placenta and human red cell were purified and sequenced by a combination of Edman degradation and tandem mass spectrometry. Screening of a human placental lambda gt11 cDNA library yielded overlapping cDNA clones
Bernardo de Souza et al.
Inorganic chemistry, 52(7), 3594-3596 (2013-03-19)
Herein we describe the synthesis of a new heterodinuclear Fe(III)Cu(II) model complex for the active site of purple acid phosphatases and its binding to a polyamine chain, a model for the amino acid residues around the active site. The properties
Jenifer H Anklesaria et al.
PloS one, 8(3), e58631-e58631 (2013-03-08)
Prostate Secretory Protein of 94 amino acids (PSP94) is one of the major proteins present in the human seminal plasma. Though several functions have been predicted for this protein, its exact role either in sperm function or in prostate pathophysiology
Ryosuke Yamaguchi et al.
Rheumatology (Oxford, England), 53(12), 2191-2195 (2014-06-25)
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis
Suiyi Tan et al.
PloS one, 8(3), e59777-e59777 (2013-04-02)
Polyanionic candidate microbicides, including cellulose sulfate, carrageenan, PRO 2000, were proven ineffective in preventing HIV-1 transmission and even cellulose sulfate showed increased risk of HIV acquisition in the Phase III efficacy trials. Semen plays critical roles in HIV-1 sexual transmission.
S A Alfaqeeh et al.
Journal of dental research, 92(12), 1129-1135 (2013-10-25)
The tooth works as a functional unit with its surrounding bony socket, the alveolar bone. The growth of the tooth and alveolar bone is co-ordinated so that a studied distance always separates the 2, known as the tooth-bone interface (TBI).
Keith D Kikawa et al.
The Journal of biological chemistry, 277(42), 39274-39279 (2002-08-09)
Intracellular signaling by protein tyrosine phosphorylation is generally understood to govern many aspects of cellular behavior. The biological consequences of this signaling pathway are important because the levels of protein tyrosine phosphorylation are frequently elevated in cancer cells. In the
A Canellada et al.
Placenta, 34(3), 231-239 (2013-01-26)
Previous studies showed that placental extracts (PE) alleviates arthritic symptoms in animal models of arthritis. To evaluate whether murine PEs obtained at embryonic days 7.5 (PE7) and 17.5 (PE18) regulate RANKL-induced osteoclast differentiation, RAW 264.7 cells were cultured with RANKL
Weirong Xing et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 28(9), 1962-1974 (2013-03-26)
To assess the roles of Lrrk1 and Lrrk2, we examined skeletal phenotypes in Lrrk1 and Lrrk2 knockout (KO) mice. Lrrk1 KO mice exhibit severe osteopetrosis caused by dysfunction of multinucleated osteoclasts, reduced bone resorption in endocortical and trabecular regions, and
Tsai-Der Chuang et al.
The Journal of biological chemistry, 285(31), 23598-23606 (2010-05-26)
Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. Nevertheless, the direct interaction between cPAcP and ErbB-2 has not
Celestyna Mila-Kierzenkowska et al.
Oxidative medicine and cellular longevity, 2013, 438321-438321 (2013-03-28)
The aim of the study was to determine the concentration of lipid peroxidation products, the activity of selected antioxidant and lysosomal enzymes, and protease inhibitor in patients with renal cell carcinoma who underwent radical nephrectomy. The studied group included 44
Paul Redhead et al.
Science & justice : journal of the Forensic Science Society, 53(2), 187-191 (2013-04-23)
The ability to detect semen in sexual offence cases is a crucial first step to locating stains which may be suitable for DNA profiling. Since the development of the acid phosphatase test in the late 1950s by Stuart S. Kind
Daniela S Gerhard et al.
Genome research, 14(10B), 2121-2127 (2004-10-19)
The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random
Zuzana Novotná et al.
FEBS letters, 554(1-2), 50-54 (2003-11-05)
Phospholipase D (PLD) forms the major family of phospholipases that was first discovered and cloned in plants. In this report we have shown, for the first time, that C2 phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent PLD(s) from 5 day hypocotyls of Brassica oleracea associated
Acid phosphatase. VII. Yeast phosphomonoesterase; isolation procedure and stability characteristics.
K K TSUBOI et al.
The Journal of biological chemistry, 224(2), 621-635 (1957-02-01)
Norbert Sträter et al.
Journal of molecular biology, 351(1), 233-246 (2005-07-05)
The crystal structure of human purple acid phosphatase recombinantly expressed in Escherichia coli (rHPAP(Ec)) and Pichia pastoris (rHPAP(Pp)) has been determined in two different crystal forms, both at 2.2A resolution. In both cases, the enzyme crystallized in its oxidized (inactive)
Hai-Dong Liang et al.
Molecular biology reports, 40(2), 757-763 (2012-12-13)
We studied molecular mechanism of Cistanches Herba aqueous extract (CHAE) in ovariectomized (OVX) rats, as an experimental model of postmenopausal osteoporosis. Female rats were either sham-operated or bilaterally OVX; and at 60 days postoperatively. The OVX group (n = 8) received an ovariectomy
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