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Hidetomo Kikuchi et al.
International journal of oncology, 45(2), 843-852 (2014-05-27)
We have demonstrated that an extract from the ripe fruit of Vitex angus-castus (Vitex), might be a promising anticancer candidate. In order to further provide a molecular rationale for clinical development in anticancer therapy, a detailed mechanism underlying the efficacy
Jesús Alberto Pérez-Romero et al.
Plants (Basel, Switzerland), 9(6) (2020-06-03)
Many halophytic physiological traits related to the tolerance of plants to salinity excess have been extensively studied, with a focus on biomass and/or gas exchange parameters. To gain a more complete understanding of whether salinity excess affects the physiological performance
Martina Maccesi et al.
Parasites & vectors, 12(1), 493-493 (2019-10-24)
Over the past five years, as a public service to encourage and accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasis Boxes. Here
Lucian Farcal et al.
PloS one, 10(5), e0127174-e0127174 (2015-05-23)
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for
Oxidation of winery wastewater by sulphate radicals: catalytic and solar photocatalytic activations.
Jorge Rodríguez-Chueca et al.
Environmental science and pollution research international, 24(28), 22414-22426 (2017-08-15)
The treatment of winery effluents through sulphate radical-based advanced oxidation processes (SR-AOPs) driven by solar radiation is reported in this study. Photolytic and catalytic activations of peroxymonosulphate (PMS) and persulphate (KPS and SPS) at different pH values (4.5 and 7)
Sae-Bom Kwon et al.
Journal of microbiology and biotechnology, 25(3), 343-352 (2015-01-08)
H9 is an ethanol extract prepared from nine traditional/medicinal herbs. This study was focused on the anticancer effect of H9 in non-small-cell lung cancer cells. The effects of H9 on cell viability, apoptosis, mitochondrial membrane potential (MMP; Δφm), and apoptosis-related
Katherine E Vest et al.
Human molecular genetics, 26(17), 3235-3252 (2017-06-03)
Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease caused by polyalanine expansion in the poly(A) binding protein nuclear 1 (PABPN1). Several mouse models have been generated to study OPMD; however, most of these models have employed transgenic overexpression of
Jully Oyama et al.
Acta tropica, 192, 11-21 (2019-01-20)
Leishmaniasis is a neglected disease and drugs approved for its treatment often lead to abandonment, failure of therapy and even death. Photodynamic therapy (PDT) has been shown to be a promising, non-invasive and selective for a target region without requiring
Munetaka Shimamura et al.
Journal of bioscience and bioengineering, 105(3), 243-248 (2008-04-10)
A hydroxylamine oxidoreductase (HAO) was purified from anammox sludge in which an anammox bacterium, strain KSU-1, was dominant. The enzyme was a 118-kDa homodimer composed of a 53-kDa subunit. With phenazine methosulfate and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide as electron acceptors, the V(max)
Kara Osburn et al.
Food microbiology, 70, 76-84 (2017-11-28)
In the beverage fermentation industry, especially at the craft or micro level, there is a movement to incorporate as many local ingredients as possible to both capture terroir and stimulate local economies. In the case of craft beer, this has
Xuezhen Zhu et al.
Journal of medicinal chemistry, 62(18), 8578-8608 (2019-08-30)
The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A homodimer, Ac22(Az8)
Merryl R Lobo et al.
PloS one, 9(12), e114110-e114110 (2014-12-10)
We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine. The current study investigates the role of hypoxia and autophagy in
Hao Zhang et al.
Frontiers in psychiatry, 11, 295-295 (2020-05-01)
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PMS/PMDD patients; however, side effects
Jan Leipert et al.
Analytical and bioanalytical chemistry, 410(19), 4737-4748 (2018-02-23)
The identification and quantification of molecules involved in bacterial communication are major prerequisites for the understanding of interspecies interactions at the molecular level. We developed a procedure allowing the determination of 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) and the virulence factor
Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes
Pierson LS, et al.
Applied Microbiology and Biotechnology, 86(6), 1659-1670 (2010)
Mohammad Arabpour et al.
Journal of drug targeting, 25(4), 360-369 (2016-11-26)
Activated hepatic stellate cells (HSCs) are known to play a central role in liver fibrosis and their elimination is a crucial step toward the resolution and reversion of liver fibrosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a molecule that
Sanjay K S Patel et al.
Bioresource technology, 304, 123022-123022 (2020-02-20)
Type I (Methylomicrobium album) and II (Methyloferula stellata) methanotrophs were encapsulated by alginate and polyvinyl alcohol (PVA) to improve methanol production from simulated biogas [methane (CH4) and carbon dioxide (CO2)] in the presence of CH4 vector. Polymeric matrix alginate (2%)
Yueping Bao et al.
Water research, 151, 64-74 (2018-12-30)
In this work, nano-bimetallic Co/Fe oxides with different stoichiometric Co/Fe ratios were prepared using a novel one-step solution combustion method. The nano-bimetallic Co/Fe oxides were used for sulfamethoxazole (SMX) degradation via peroxymonosulfate (PMS) activation. The stoichiometric efficiencies of the as-prepared
Diana K Morales et al.
Molecular microbiology, 78(6), 1379-1392 (2010-12-15)
Pseudomonas aeruginosa produces several phenazines including the recently described 5-methyl-phenazine-1-carboxylic acid (5MPCA), which exhibits a novel antibiotic activity towards pathogenic fungi such as Candida albicans. Here we characterize the unique antifungal mechanisms of 5MPCA using its analogue phenazine methosulphate (PMS).
E M Costa et al.
Journal of applied microbiology, 122(6), 1547-1557 (2017-04-04)
Chitosan is a natural compound that has been validated as a viable antimicrobial agent against Staphylococcus aureus. With this work we sought to evaluate the planktonic and sessile sensitivity of methicillin-resistant S. aureus to chitosan's activity and evaluate if methicillin-resistant
Dongwen Lv et al.
Nature communications, 12(1), 6896-6896 (2021-11-27)
PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activity remain elusive. Through computational modelling of the entire NEDD8-VHL Cullin RING E3 ubiquitin ligase
Alessandra Berto et al.
Food & function, 6(9), 3081-3090 (2015-07-28)
Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For
Suvomoy Sana et al.
International journal of nanomedicine, 12, 4059-4071 (2017-06-13)
The importance of fluoride as a natural and industrial toxicant is recognized worldwide. We evaluated the regulating role and biological effect of vesicular (liposomal and nanoencapsulated) melatonin (N-acetyl-5-methoxytryptamine) for drug delivery and controlled release on the depletion of inflammatory mediators
Ziyad Ben Ahmed et al.
The Analyst, 145(2), 557-571 (2019-11-27)
Antioxidant activity can be measured by a variety of methods, that include hydrogen atom transfer (HAT) and single electron transfer (ET) methods. Most of these techniques are spectrophotometric, and thus incapable of quantifying or indicting individual antioxidant compounds. Nowadays, the
Alexandra Sorvina et al.
Cells, 9(2) (2020-02-09)
Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators, such as antimicrobial peptides and pro-inflammatory cytokines. However, when dysregulated, innate immunity can contribute to multifactorial diseases, including
Hawzhin Amanollahi et al.
Journal of hazardous materials, 402, 123789-123789 (2020-12-02)
In this work, the VUV, VUV/H2O2, VUV/PMS, and VUV/H2O2/PMS processes were compared with the corresponding UVC-based AOPs under identical experimental conditions for the ammonia removal. Among the examined AOPs, the VUV/H2O2/PMS demonstrated the highest performance in converting NH4+ to N2.
Jacob Rune Jørgensen et al.
Pharmaceutics, 12(1) (2020-01-16)
Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with unidirectionally releasing microcontainers (MCs) has previously been shown to increase
José Carlos Rebuglio Vellosa et al.
Archives of pharmacal research, 38(6), 1168-1177 (2014-10-16)
Biological activities of flavonoids have been extensively reviewed in literature. The biochemical profile of afzelin, kaempferitrin, and pterogynoside acting on reactive oxygen species was investigated in this paper. The flavonoids were able to act as scavengers of the superoxide anion
Wioletta Rut et al.
Nature chemical biology, 17(2), 222-228 (2020-10-24)
In December 2019, the first cases of infection with a novel coronavirus, SARS-CoV-2, were diagnosed. Currently, there is no effective antiviral treatment for COVID-19. To address this emerging problem, we focused on the SARS-CoV-2 main protease that constitutes one of
Somenath Roy Chowdhury et al.
Scientific reports, 8(1), 11940-11940 (2018-08-11)
Kinetoplast DNA (kDNA) bearing unusual mitochondrion of trypanosomatid parasites offers a new paradigm in chemotherapy modality. Topoisomerase II of Leishmania donovani (LdTopII), a key enzyme associated with kDNA replication, is emerging as a potential drug target. However, mode of action
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