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PHR1022
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Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.
Thuy T B Vo et al.
Reproductive toxicology (Elmsford, N.Y.), 29(3), 306-316 (2010-02-06)
In this study, a female pubertal assay on the effects of parabens, including methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutylparaben, was performed in a female Sprague-Dawley rat model during the juvenile-peripubertal period. The rats were orally treated with these parabens
Piyapong Choochana et al.
Pharmaceutical biology, 53(4), 477-482 (2014-12-05)
There is a need for the discovery of novel natural and semi-synthetic sunscreen that is safe and effective. Piperine has a UV absorption band of 230-400 nm with high molar absorptivity. This compound has a high potential to be developed to
James M Mathews et al.
Xenobiotica; the fate of foreign compounds in biological systems, 43(2), 169-181 (2012-07-27)
n-Butyl-p-hydroxybenzoate (n-butylparaben, BPB) is an antioxidant used in foods, pharmaceuticals and cosmetics. This study investigated the disposition of ring-labelled [(14)C]BPB in Harlan Sprague Dawley rats, and in rat and human hepatocytes. BPB was rapidly cleared in hepatocytes from rat (t(1/2)
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1360, 275-287 (2014-08-19)
Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study
M Khimani et al.
The journal of physical chemistry. B, 116(51), 14943-14950 (2012-12-06)
The influence of methyl paraben (MP) and butyl paraben (BP) on the aggregation characteristics of Pluronics in an aqueous medium has been investigated by DLS, SANS, viscometry, and fluorescence measurement techniques. Parabens are extensively used as preservatives in cosmetic, pharmaceutical
Antonis Myridakis et al.
Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)
Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA
Evaluation of PGC Stationary Phases Under High-Temperature LC Conditions for the Analysis of Parabens in Food Samples
La Tella R, et al.
LC-GC, 36(5), 8-8 (2023)
A Beltran et al.
Analytica chimica acta, 677(1), 72-78 (2010-09-21)
In this paper we describe the synthesis, characterisation and use of two distinct molecularly imprinted polymers (MIPs) prepared using esters of p-hydroxybenzoic acid (parabens) as templates: one MIP was synthesised by precipitation polymerisation using a semi-covalent molecularly imprinting strategy with
Dorota Gryglik et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 8(4), 549-555 (2009-04-02)
The photosensitized oxidation of butyl p-hydroxybenzoate (butylparaben, BP), the endocrine disrupting compound, in aqueous solution using rose bengal (RB) and aluminium phthalocyanine chloride tetrasulfonic acid (PC) as sensitizers was examined. A xenon lamp simulating solar radiation was used as a
Anchel González-Barriga et al.
PloS one, 10(3), e0121556-e0121556 (2015-03-24)
Myotonic Dystrophy type 1 (DM1) is a multisystemic disease caused by toxic RNA from a DMPK gene carrying an expanded (CTG•CAG)n repeat. Promising strategies for treatment of DM1 patients are currently being tested. These include antisense oligonucleotides and drugs for
Mari Egawa et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(3), 196-204 (2012-03-02)
Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation
Anuschka Liekens et al.
Journal of chromatography. A, 1218(38), 6654-6662 (2011-08-25)
The effect of the addition of 25%, 50% and 75% (weight percent, wt%) of larger particles (resp. 3 and 5 μm) to a commercial batch of 1.9 μm particles has been investigated as an academic exercise to study the effects
Anna Viridén et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 99-110 (2010-11-18)
This study investigates the effect of the chemical heterogeneity of hydroxypropyl methylcellulose (HPMC) on the release of model drug substances from hydrophilic matrix tablets. The hypothesis was that the release of drug substances could be influenced by possible interactions with
C J Park et al.
Andrologia, 44 Suppl 1, 187-193 (2011-05-20)
Parabens have been shown to affect male rodent reproductive parameters, including testosterone levels and sperm production. In this study, we examined the effect of long-term exposure to butyl paraben (BP) on rat epididymal sperm DNA methylation. Adult male rats were
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Eric A Gurzell et al.
The Journal of nutritional biochemistry, 26(4), 369-377 (2015-01-27)
We previously reported that docosahexaenoic-acid (DHA)-enriched fish oil (DFO) feeding altered B-cell membrane organization and enhanced B-cell function. The purpose of this study was to evaluate whether menhaden oil (MO) and eicosapentaenoic-acid (EPA)-enriched fish oil (EFO) alters B-cell function/phenotype similarly.
Najma Memon et al.
Journal of separation science, 28(7), 635-638 (2005-05-26)
An analytical procedure has been developed for the analysis of benzoic acid, p-hydroxybenzoic acid, methyl-, ethyl-, propyl-, isopropyl-, and butyl esters of p-hydroxybenzoic acid by micellar liquid chromatography. After dilution in n-propanol the sample was directly injected onto a Lichrosorb
Superbug hideout: finding MRSA in U.S.wastewater treatment plants.
Rebecca Kessler
Environmental health perspectives, 120(11), A437-A437 (2012-11-03)
Darrell R Kapczynski et al.
Vaccine, 33(9), 1197-1205 (2015-01-24)
Vaccination is an important tool in the protection of poultry against avian influenza (AI). For field use, the overwhelming majority of AI vaccines produced are inactivated whole virus formulated into an oil emulsion. However, recombinant vectored vaccines are gaining use
Jarmila Knitlova et al.
PloS one, 9(12), e114374-e114374 (2014-12-09)
Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replicating Modified vaccinia virus Ankara (MVA) has been under clinical development. MVA seems to
Ivana Klopčič et al.
Toxicology letters, 232(2), 376-383 (2014-12-03)
Endocrine-disrupting compounds can interfere with the endocrine organs or hormone system and cause tumors, birth defects and developmental disorders in humans. The estrogen-like activity of compounds has been widely studied but little is known concerning their possible modulation of the
Kasper Skov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 83-88 (2014-12-23)
Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metabolome. Sample preparation prior to LC-MS based analysis
Hiroshi Yamamoto et al.
Environmental sciences : an international journal of environmental physiology and toxicology, 14 Suppl, 73-87 (2008-07-24)
Butylparaben and benzylparaben, used as preservatives mainly in cosmetic products, have recently been found to be weakly estrogenic. Batch activated-sludge treatment and batch chlorination were carried out to roughly determine the removal efficiency of a wastewater treatment plant. Combining the
Szabolcs Fekete et al.
Journal of chromatography. A, 1359, 124-130 (2014-07-30)
In this study, the retention changes induced by frictional heating were evaluated for model small compounds (150-190Da) and a small protein, namely insulin (5.7kDa). For this purpose, the effect of longitudinal temperature gradient caused by frictional heating was experimentally dissociated
Johan Unga et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 73(2), 260-268 (2009-06-11)
The solid state behaviour of polyethylene glycol 4000 (PEG 4000) and dispersions of a homologous series of parabens (methyl- (MP), ethyl- (EP), propyl- (PP) and butyl- (BP)) were examined and compared to the paraben solubility in liquid PEG 400. Dispersions
Patrick Atheba et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(10), 2141-2147 (2013-05-17)
The present work evaluates the potential of the photocatalysis (PC) process for the degradation of butylparaben (BPB). Relatively high treatment efficiency was achieved by comparison to photochemical process. Prior to photocatalytic degradation, adsorption (AD) of BPB occurred on the titanium
Katra Kolšek et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(1), 8-15 (2014-09-07)
A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industrial chemicals that disrupt endocrine activity were
Long V Nguyen et al.
Nature communications, 5, 5871-5871 (2014-12-24)
Genomic and phenotypic analyses indicate extensive intra- as well as intertumoral heterogeneity in primary human malignant cell populations despite their clonal origin. Cellular DNA barcoding offers a powerful and unbiased alternative to track the number and size of multiple subclones
Antonia M Calafat et al.
Environmental health perspectives, 118(5), 679-685 (2010-01-09)
Parabens are widely used as antimicrobial preservatives in cosmetics, -pharmaceuticals, and food and beverage processing. We assessed exposure to methyl, ethyl, propyl, and butyl parabens in a representative sample of persons >or= 6 years of age in the U.S. general
Anna Maria Wróbel et al.
Toxicology letters, 230(3), 375-381 (2014-08-17)
Numerous studies have shown that widely used parabens possess estrogenic properties. In the present study, we examined the effects of methyl-, propyl- and butylparaben on the mRNA and protein expression of estrogen receptor (ER)-α (ESR1) and -β (ESR2) and the
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