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显示 1-30 共 890 条结果 关于 "PHR1552" 范围 论文
Jesse Hawley et al.
PloS one, 9(6), e99165-e99165 (2014-06-10)
The nutritional composition of diets can vary widely in nature and have large effects on the growth, reproduction and survival of animals. Many animals, especially herbivores, will tightly regulate the nutritional composition of their body, which has been referred to
Francisco Ortiz et al.
Journal of pineal research, 58(1), 34-49 (2014-11-13)
Mucositis is a common and distressing side effect of chemotherapy or radiotherapy that has potentially severe consequences, and no treatment is available. The purpose of this study was to analyze the molecular pathways involved in the development of oral mucositis
Gesche Först et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 559-569 (2014-04-01)
Since pharmacokinetic and pharmacodynamic activities of drugs are often related to their interactions with biomembranes, it is of high interest to establish an approach for the characterization of these interactions at the molecular level. For the present study, beta-blockers (oxprenolol
João F Requicha et al.
Tissue engineering. Part A, 20(17-18), 2483-2492 (2014-03-01)
Human and canine periodontium are often affected by an inflammatory pathology called periodontitis, which is associated with severe damages across tissues, namely, in the periodontal ligament, cementum, and alveolar bone. However, the therapies used in the routine dental practice, often
J Justin Milner et al.
PloS one, 9(5), e97238-e97238 (2014-05-23)
Obese individuals are at greater risk for death from influenza virus infection. Paralleling human evidence, obese mice are also more susceptible to influenza infection mortality. However, the underlying mechanisms driving greater influenza severity in the obese remain unclear. Metabolic profiling
Handan Uysal et al.
Toxicology and industrial health, 31(1), 44-51 (2012-12-12)
In this study, potential genotoxic effects of ethyl methanesulfonate (EMS) that caused mutagenicity in a variety of organisms were tried to resolve by the methanol and chloroform extract of Echium amoenum (EAmet and EAchl) Fisch. & C.A. Mey. from the
R Galatola et al.
Biochimica et biophysica acta, 1848(2), 392-407 (2014-12-03)
The interaction between a peptide sequence from GB virus C E1 protein (E1P8) and its structural analogs (E1P8-12), (E1P8-13), and (E1P8-21) with anionic lipid membranes (POPG vesicles and POPG, DPPG or DPPC/DPPG (2:1) monolayers) and their association with HIV-1 fusion
Lorraine B Ferreira et al.
Journal of biomaterials applications, 29(7), 965-976 (2014-09-12)
Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria. PLGA scaffolds (50:50 ratio) were synthesized as pure membranes or as microspheres loaded
Delair Silveira Dos Santos et al.
Acta pharmaceutica (Zagreb, Croatia), 64(4), 495-501 (2014-12-23)
This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and
Elena Buelow et al.
The Journal of antimicrobial chemotherapy, 69(8), 2215-2223 (2014-04-09)
Selective digestive decontamination (SDD) is an infection prevention measure for critically ill patients in intensive care units (ICUs) that aims to eradicate opportunistic pathogens from the oropharynx and intestines, while sparing the anaerobic flora, by the application of non-absorbable antibiotics.
Frauke Goeman et al.
The Journal of steroid biochemistry and molecular biology, 143, 348-356 (2014-04-15)
There is growing evidence that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) plays a role in breast cancer prevention and survival. It elicits a variety of antitumor activities like controlling cellular differentiation, proliferation and angiogenesis. Most of its biological effects are exerted via its
Lei Yao et al.
Journal of hazardous materials, 280, 428-435 (2014-09-10)
A novel surfactant encapsulated polyoxometalate (SEP) has been synthesized by using a simple ion-exchange reaction. The prepared SEP complex was found to self-assemble into nanospherical particles whose morphology and component were characterized by TEM and XPS. The SEP was further
Jelena Drazenovic et al.
Biochimica et biophysica acta, 1848(2), 532-543 (2014-12-03)
Nano-differential scanning calorimetry (nano-DSC) is a powerful tool in the investigation of unilamellar (small unilamellar, SUVs, or large unilamellar, LUVs) vesicles, as well as lipids on supported bilayers, since it measures the main gel-to-liquid phase transition temperature (Tm), enthalpies and
Shinichi Yoda et al.
Nature communications, 5, 4936-4936 (2014-09-19)
Genetic polymorphisms underlie the convergent and divergent evolution of various phenotypes. Diverse colour patterns on caterpillars, which are ecologically important, are good models for understanding the molecular backgrounds of phenotypic diversity. Here we show that a single evolutionarily conserved gene
David A Nagel et al.
Environmental toxicology and pharmacology, 38(3), 968-976 (2014-12-03)
Mixtures of pesticides in foodstuffs and the environment are ubiquitous in the developed world and although agents are usually exhaustively tested individually, the toxicological implications of pesticide mixtures are underreported. In this study, the effects of two fungicides, fenhexamid and
Ivana Milic et al.
Journal of mass spectrometry : JMS, 50(3), 603-612 (2015-03-25)
Highly reactive lipid peroxidation-derived carbonyls (oxoLPP) modify protein nucleophiles via Michael addition or Schiff base formation. Once formed, Michael adducts can be further stabilized via cyclic hemiacetals with or without loss of water. Depending on the mechanism of their formation
Hussain Mohamad Awwad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 41-45 (2014-03-29)
We aimed at developing a method for the measurement of choline and its metabolites in whole blood (WB). After an extraction step, quantification of choline, betaine, and dimethylglycine (DMG) was performed using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
Wolfgang Dohle et al.
ChemMedChem, 9(8), 1783-1793 (2014-05-14)
Tetrahydroisoquinoline (THIQ)-based "chimeric" microtubule disruptors were optimised through modification of the N-benzyl motif, in concert with changes at C3 and C7, resulting in the identification of compounds with improved in vitro antiproliferative activities (e.g. 15: GI50 20 nM in DU-145). The
Shalene Sankhagowit et al.
Biochimica et biophysica acta, 1838(10), 2615-2624 (2014-07-08)
We have studied the dynamics of Lissamine Rhodamine B dye sensitization-induced oxidation of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) giant unilamellar vesicles (GUVs), where the progression of the underlying chemical processes was followed via vesicle membrane area changes. The surface-area-to-volume ratio of our spherical
C I O'Connor-Robison et al.
Journal of animal science, 92(10), 4607-4615 (2014-09-04)
Dietary long-chain PFO including arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are precursors for several inflammatory mediators. The objective of this study was to characterize the effects of dietary PFO supplementation on bone, cartilage, and synovial fluid
Anders K Nilsson et al.
Phytochemistry, 101, 65-75 (2014-02-25)
Plant membranes are composed of a wide array of polar lipids. The functionality of these extends far beyond a pure structural role. Membrane lipids function as enzyme co-factors, establish organelle identity and as substrates for enzymes such as lipases and
Qing Shen et al.
Analytical and bioanalytical chemistry, 407(5), 1475-1484 (2014-12-11)
Salmon is a popular food but it is easily susceptible to spoilage by contamination with microorganisms. In this study, a method using hydrophilic interaction chromatography (HILIC)-based solid-phase extraction (SPE) and matrix-assisted laser desorption and ionization time-of-flight/time-of-flight mass spectrometry was developed
Kelly Yoshizaki et al.
Respiratory research, 16, 18-18 (2015-04-08)
Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by
Richa et al.
Protoplasma, 252(1), 199-208 (2014-07-06)
We have screened two Nostoc species inhabiting diverse habitats for the presence of sunscreening mycosporine-like amino acid (MAA) compounds. The identification and characterization of one MAA (RT 3.1-3.8 min, λmax -334 nm) from both Nostoc species were performed using absorption spectroscopy, high-performance
Masakazu Nagafuku et al.
Glycobiology, 25(3), 303-318 (2014-10-12)
Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. Macrophage-secreted factors
Yoshito Tanaka et al.
Nitric oxide : biology and chemistry, 40, 75-86 (2014-06-01)
Supplementation of active hexose correlated compound (AHCC) improved the prognosis of postoperative hepatocellular carcinoma patients. Excess production of nitric oxide (NO) by inducible NO synthase (iNOS) is an inflammatory biomarker in liver injury. AHCC suppressed iNOS induction in hepatocytes, suggesting
Meijun Du et al.
Human molecular genetics, 24(1), 154-166 (2014-08-26)
Chromosome 8q24 locus contains regulatory variants that modulate genetic risk to various cancers including prostate cancer (PC). However, the biological mechanism underlying this regulation is not well understood. Here, we developed a chromosome conformation capture (3C)-based multi-target sequencing technology and
Runa Kuley et al.
PloS one, 10(3), e0121661-e0121661 (2015-03-21)
Q fever is caused by the obligate intracellular bacterium Coxiella burnetii. In vitro growth of the bacterium is usually limited to viable eukaryotic host cells imposing experimental constraints for molecular studies, such as the identification and characterisation of major virulence
T Wu et al.
Organic & biomolecular chemistry, 13(8), 2317-2322 (2015-01-03)
The synthesis of water-dispersible nano-assemblies containing upconverting nanoparticles (UCNPs) and porphyrin molecules using a one-pot method is described. When the nano-assemblies are excited by 980 nm near-infrared light, the intensity of the 'green emission' band of the UCNP is reduced
Rasika S Phansalkar et al.
Fitoterapia, 101, 169-178 (2014-12-30)
Grape seeds are a rich source of polyphenols, especially proanthocyanidins (PACs), and are also known for the presence of galloylated oligomeric PACs (OPACs). The present study focuses on the phytochemical methodology for grape seed (O)PACs and their potential role as
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