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AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.

AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.

The Journal of antibiotics (2014-05-29)

Keisuke Ohsumi, Teruhisa Masaki, Shigehiro Takase, Masato Watanabe, Akihiko Fujie

摘要

A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed antifungal activity against Trichophyton species.

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