S4808

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关键词:'S4808'

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Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

Amani A Mahbub et al.

Anti-cancer agents in medicinal chemistry, 13(10), 1601-1613 (2013-06-26)

Mortality rates for leukemia are high despite considerable improvements in treatment. Since polyphenols exert pro-apoptotic effects in solid tumors, our study investigated the effects of polyphenols in haematological malignancies. The effect of eight polyphenols (quercetin, chrysin, apigenin, emodin, aloe-emodin, rhein

Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.

Wei Zhang et al.

Bioorganic & medicinal chemistry letters, 21(3), 1032-1035 (2011-01-11)

A series of methoxystilbenes (E and Z isomers) related to resveratrol were investigated for their effects on NQO1 induction in murine hepatoma cells and growth inhibitory effects on human cancer cell lines. Both activities were enhanced in compounds with methoxy

Strong, Nonresonant Radiation Enhances Cis-Trans Photoisomerization of Stilbene in Solution.

Jana L van den Berg et al.

The journal of physical chemistry. A, 124(29), 5999-6008 (2020-06-26)

Previously, it has been demonstrated that external electric fields may be used to exert control over chemical reactivity. In this study, the impact of a strong, nonresonant IR field (1064 nm) on the photoisomerization of cis-stilbene is investigated in cyclohexane

Epoxidation of stilbene using supported gold nanoparticles: cumyl peroxyl radical activation at the gold nanoparticle surface.

Crites COL, et al.

Chemical Communications (Cambridge, England), 50(18), 2289-2291 (2014)

Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities.

Hassan E Eldesouky et al.

Scientific reports, 10(1), 6089-6089 (2020-04-10)

Azole antifungals are vital therapeutic options for treating invasive mycotic infections. However, the emergence of azole-resistant isolates combined with limited therapeutic options presents a growing challenge in medical mycology. To address this issue, we utilized microdilution checkerboard assays to evaluate

Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols.

Hesam Arabnejad et al.

Chembiochem : a European journal of chemical biology, 21(13), 1893-1904 (2020-01-22)

The use of enzymes in preparative biocatalysis often requires tailoring enzyme selectivity by protein engineering. Herein we explore the use of computational library design and molecular dynamics simulations to create variants of limonene epoxide hydrolase that produce enantiomeric diols from

High-performance liquid chromatography separation of unsaturated organic compounds by a monolithic silica column embedded with silver nanoparticles.

Yang Zhu et al.

Journal of separation science, 38(16), 2841-2847 (2015-06-23)

The optimization of a porous structure to ensure good separation performances is always a significant issue in high-performance liquid chromatography column design. Recently we reported the homogeneous embedment of Ag nanoparticles in periodic mesoporous silica monolith and the application of

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System.

Jakub Treml et al.

Biomolecules, 9(9) (2019-09-12)

The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive

Periodic Trends in Olefin Epoxidation over Group IV and V Framework-Substituted Zeolite Catalysts: A Kinetic and Spectroscopic Study.

Daniel T Bregante et al.

Journal of the American Chemical Society, 139(20), 6888-6898 (2017-04-30)

Group IV and V framework-substituted zeolites have been used for olefin epoxidation reactions for decades, yet the underlying properties that determine the selectivities and turnover rates of these catalysts have not yet been elucidated. Here, a combination of kinetic, thermodynamic

Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.

Mankil Jung et al.

Bioorganic & medicinal chemistry letters, 17(16), 4481-4486 (2007-06-29)

Dihydroxy stilbene derivatives were designed based on lithospermic acid B and were prepared from 4-(chloromethyl)benzoic acid. The inhibitory activities of the novel compounds against protein tyrosine phosphatase 1B (PTP1B) were evaluated. 3,4-Dihydroxy stilbene carbonyl compounds (7, 11b, 27b) inhibited PTP1B

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