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关键词:'T1539'
显示 1-30 共 336 条结果 关于 "T1539" 范围 论文
András Nemes et al.
Journal of medicinal chemistry, 51(3), 479-486 (2008-01-11)
A series of trans-2'-hydroxyethyl and 2'-acyloxyethyl apovincaminates 4b- f and 7b- f has been synthesized and evaluated for their antioxidant and antiamnesic effects. The new esters were prepared from 4a and 7a ethyl esters or from the corresponding carboxylic acid
Zohra Ghlissi et al.
Environmental toxicology and pharmacology, 37(3), 960-966 (2014-04-09)
We evaluated the effect of astaxanthin (ASX) and vitamin E (vit E) on colistin methanesulfonate (CMS) induced-nephrotoxicity in rats. Animals were treated with sterile saline, 300000 or 450 000 IU/kg/day of CMS, CMS + ASX (20 mg/kg), CMS + vit
Takashi Abe et al.
Neuroscience letters, 336(2), 105-108 (2002-12-25)
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with
Jean-Marc Zingg et al.
Archives of biochemistry and biophysics, 538(2), 111-119 (2013-09-03)
Of the 8 different analogues (α-, β-, γ-, δ-tocopherols and tocotrienols) designated as vitamin E, alpha-tocopherol (α-T) has been mostly studied, together with gamma-tocopherol (γ-T) which is abundant in the US diet. We compared the effect of dietary supplementation with
J Valtueña et al.
Nutricion hospitalaria, 26(2), 280-288 (2011-06-15)
Currently, blood levels to define vitamin deficiency or optimal status in adolescents are extrapolated from adults. This may be not adequate as vitamin requirements during adolescence depend on the process of sexual maturation, rapid increasing height and weight, among other
Murugesan Saravanakumar et al.
The British journal of nutrition, 114(9), 1385-1394 (2015-09-09)
In our previous studies, veratric acid (VA) shows beneficial effect on hypertension and its associated dyslipidaemia. In continuation, this study was designed to investigate the effect of VA, one of the major benzoic acid derivatives from vegetables and fruits, on
Young-Sik Jung et al.
Bioorganic & medicinal chemistry letters, 15(4), 1125-1129 (2005-02-03)
Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 microM of the IC(50) value.
Faridah Abas et al.
Journal of natural products, 68(7), 1090-1093 (2005-07-26)
A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures
Ying-Chen Chen et al.
International journal of pharmaceutics, 473(1-2), 458-468 (2014-08-05)
A growing number of poorly water-soluble drug have been discovered, but the poor bioavailability is a critical problem. In this study, physical properties and dissolution profiles of cilostazol solid dispersions prepared by hydrophilic/lipophilic excipients (Kollidon(®) VA64, tocopheryl polyethylene glycol succinate
T Sakai et al.
Clinical chemistry, 36(3), 474-476 (1990-03-01)
We devised a kit for use with automated analyzers, for assay of urinary free L-fucose by means of a newly isolated L-fucose dehydrogenase (EC 1.1.1.122), and we measured L-fucose in healthy subjects, cancer patients, and patients with other diseases. It
Xue-Qing Chen et al.
Journal of pharmaceutical sciences, 103(12), 3924-3931 (2014-10-14)
BMS-B is a highly lipophilic compound (clog P 7.72) with poor aqueous solubility (<10 ng/mL at pH 1 and 6.5). The compound exhibits low bioavailability in preclinical species when dosed as cosolvent solution formulations, with reduced exposure upon dose escalation.
Chandrabose Sureka et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 93(4), 385-395 (2015-07-16)
The aim of the present study was to investigate the protective effects of Sesbania grandiflora flower (SGF) extract on erythrocyte membrane in Streptozotocin (STZ)-induced diabetic rats. Adult male albino rats of Wistar strain, weighing 190-220 g, were made diabetic by
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry, 15(10), 3309-3314 (2007-03-28)
Three new highly oxygenated and unsaturated metabolites named interfungins A (1), B (2), and C (3), which provide a diversity of hispidin class compounds in the fungi Inonotus and Phellinus, were isolated from the methanolic extract of the fruiting body
Omar F Khabour et al.
Cytotechnology, 67(6), 1051-1057 (2014-05-24)
Behcet's disease (BD) is a multisystemic chronic inflammatory disorder that presents throughout the world with high frequency in Turkey and Middle East. BD has been shown to be associated with genotoxicity as patients with the disease have demonstrated high rates
Norio Murata et al.
Biochimica et biophysica acta, 1817(8), 1127-1133 (2012-03-06)
Photoinhibition of photosystem II (PSII) occurs when the rate of light-induced inactivation (photodamage) of PSII exceeds the rate of repair of the photodamaged PSII. For the quantitative analysis of the mechanism of photoinhibition of PSII, it is essential to monitor
Karl Michaëlsson et al.
The American journal of clinical nutrition, 99(1), 107-114 (2013-11-15)
A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting. The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women
Su Jin Kang et al.
International journal of molecular sciences, 16(10), 24219-24242 (2015-10-17)
Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial properties. We examined the underlying mechanisms of dried pomegranate concentrate powder (PCP) on melanin
Rebecca K Golley et al.
The Journal of nutrition, 145(1), 128-133 (2014-12-21)
Whether dietary indexes are associated with biomarkers of children's dietary intake is unclear. The study aim was to examine the relations between diet quality and selected plasma biomarkers of dietary intake and serum lipid profile. The study sample consisted of
Björn Kruspig et al.
Mitochondrion, 13(5), 533-538 (2012-09-14)
Targeting mitochondria is a promising strategy in tumor cell elimination. d-α-tocopheryl succinate (α-TOS), a redox-silent analog of vitamin E, is a potentially powerful tool for fighting tumors by directly affecting mitochondria. However, when used at low concentrations it can suppress
A Tagde et al.
Blood cancer journal, 4, e229-e229 (2014-07-19)
Melphalan (L-PAM) has been an integral part of multiple myeloma (MM) treatment as a conditioning regimen before stem cell transplant (SCT). After initial response, most treated patients experience relapse with an aggressive phenotype. Increased glutathione (GSH) in MM may mediate
Kirsten G Coupland et al.
Movement disorders : official journal of the Movement Disorder Society, 29(13), 1606-1614 (2014-01-01)
Parkinson's disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism. The microtubule-associated protein tau (MAPT) is a susceptibility gene for idiopathic PD. Methylation levels were determined by pyrosequencing of
Yu-Tsai Yang et al.
Pharmaceutical development and technology, 19(7), 806-812 (2013-09-21)
The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit® RL PO and α-tocopherol. D-optimal mixture
Keiichiro Motohashi et al.
Journal of natural products, 73(2), 226-228 (2010-02-12)
Two new modified indole-containing peptides, JBIR-34 (1) and JBIR-35 (2), were isolated from the fermentation broth of a sponge-derived actinomycete identified by phylogenetic methods as a Streptomyces sp. (strain Sp080513GE-23). The planar structures of 1 and 2 were assigned on
Ning Li et al.
The Journal of nutrition, 137(12), 2717-2722 (2007-11-22)
Smoking increases the risk of several chronic diseases associated with elevated oxidative stress status. Almonds are a good source of antioxidant nutrients and may diminish smoking-related biomarkers of oxidative stress. We investigated whether almond consumption decreases biomarkers of oxidative stress
Y Dersjant-Li et al.
Journal of animal physiology and animal nutrition, 94(4), 413-421 (2009-08-12)
Alpha-tocopherol derived from natural source is a single stereoisomer (i.e. RRR-alpha-tocopherol), whereas synthetic alpha-tocopherol consists of a mixture of eight stereoisomers, including RRR-, RRS-, RSR-, RSS-alpha-tocopherol (the 2R isomers, R configuration at positions 2' of the phytyl tail) and SRR-
Keiko Nishio et al.
Bioorganic & medicinal chemistry, 16(24), 10332-10337 (2008-11-04)
There is increasing evidence indicating that free radicals and oxygenases such as cyclooxygenase (COX) and lipoxygenase (LOX) are related to the onset and development of neurodegenerative diseases. In order to prevent and/or delay these diseases, the use of radical-scavenging antioxidants
Melanie Eger et al.
Veterinary immunology and immunopathology, 166(1-2), 33-42 (2015-05-20)
The peripartal period of dairy cows is associated with a higher incidence of infectious diseases like mastitis or metritis, particularly in high-yielding animals. The onset of lactation induces a negative energy balance and a shift of glucose distribution toward the
Narayana Kilarkaje et al.
Fertility and sterility, 100(4), 1151-1159 (2013-07-16)
To investigate the effects of an antioxidant cocktail (AC) on bleomycin, etoposide, and cisplatin (BEP)-induced testicular dysfunction. In vivo study. Research laboratory. Adult male and female Sprague-Dawley rats. The rats were treated with three cycles of 21 days each of
Kishorchandra Gohil et al.
Molecular nutrition & food research, 54(5), 693-709 (2010-02-27)
Rodents fed alpha-tocopherol (alphaT)-depleted diets develop neuromuscular deficits. Unequivocal role of alphaT in the prevention of these deficits is confounded by possible neurotoxic oxidant products generated, ex vivo in alphaT-depleted diets. The discovery that large doses of alphaT could ameliorate
Sae-Kwang Ku et al.
World journal of gastroenterology, 15(38), 4799-4805 (2009-10-14)
To observe the effects of traditional antiinflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, alpha-tocopherol. Rats were pretreated with three different dosages of LF (500, 250
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