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tetrazoles

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关键词:'tetrazoles'
显示 1-30 共 1566 条结果 关于 "tetrazoles" 范围 论文
Zhenting Du et al.
International journal of molecular sciences, 13(4), 4696-4703 (2012-05-19)
A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in
Daniel Szulczyk et al.
Molecules (Basel, Switzerland), 26(2) (2021-01-14)
Twelve novel derivatives of N-(furan-2-ylmethyl)-1H-tetrazol-5-amine were synthesized. For obtained compound 8, its corresponding substrate single crystals were isolated and X-ray diffraction experiments were completed. In the initial stage of research, in silico structure-based pharmacological prediction was conducted. All compounds were
Preparation of a new tetrazolium salt which yields a blue pigment on reduction and its use in the demonstration of enzymes in normal and neoplastic tissues.
A M RUTENBURG et al.
Cancer research, 10(2), 113-121 (1950-02-01)
Matshawandile Tukulula et al.
Molecules (Basel, Switzerland), 25(24) (2020-12-19)
A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential antiplasmodium activity against a multidrug-resistant K1 strain and for their antitrypanosomal
Patrick Hochegger et al.
Molecules (Basel, Switzerland), 26(18) (2021-09-29)
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution. Compounds were tested for their antiplasmodial activity against
Pedro A Cano et al.
Molecules (Basel, Switzerland), 20(7), 12436-12449 (2015-07-18)
In vitro studies to fourteen previously synthesized chromone-tetrazoles and four novel fluorine-containing analogs were conducted against pathogenic protozoan (Entamoeba histolytica), pathogenic bacteria (Pseudomonas aeruginosa, and Staphylococcus aureus), and human fungal pathogens (Sporothrix schenckii, Candida albicans, and Candida tropicalis), which have
Andreii S Kritchenkov et al.
International journal of biological macromolecules, 132, 340-350 (2019-03-30)
New tetrazole derivatives of chitosan with low, moderate, and high degrees of substitution were obtained using a novel approach, i.e. metal-catalyzed 1,3-dipolar cycloaddition of azide ion to cyanoethyl chitosan in water - the most straightforward, selective and preparatively convenient route
Nicole Rüger et al.
ChemMedChem, 10(11), 1875-1883 (2015-09-05)
The JumonjiC-domain-containing histone demethylase 2A (JMJD2A, KDM4A) is a key player in the epigenetic regulation of gene expression. Previous publications have shown that both elevated and lowered enzyme levels are associated with certain types of cancer, and therefore the definite role
Edyta Łukowska-Chojnacka et al.
European journal of medicinal chemistry, 164, 106-120 (2018-12-30)
The increase of opportunistic fungal infections raises the need for design and synthesis of new antifungal agents. Taking into account that tetrazole derivatives exhibit antifungal activity, and some of them are in the phase of clinical trials, new tetrazole derivatives
Daniel Szulczyk et al.
European journal of medicinal chemistry, 186, 111882-111882 (2019-11-23)
A series of halogenated (4-methoxyphenyl)-1H-tetrazol-5-amine regioisomers (1a-9a, 1b-9b) were synthesized from their corresponding thiourea analogues (1-9). The synthesis pathway was confirmed by an X-ray crystallographic studies of 1a, 1b and 5a. Title derivatives were tested for their in vitro antitubercular activity
Firoz A Kalam Khan et al.
Archiv der Pharmazie, 349(12), 934-943 (2016-11-20)
The synthesis and screening of tetrazole-substituted biaryl acid analogs 7a-l as bacterial peptide deformylase (PDF) enzyme inhibitors is reported. The compounds 7e (IC
Chao Wang et al.
Journal of enzyme inhibition and medicinal chemistry, 36(1), 549-560 (2021-02-02)
A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be
Velladurai Rama et al.
The Journal of organic chemistry, 76(21), 9090-9095 (2011-09-14)
A simple and efficient route for the synthesis of 5-substituted 1H-tetrazoles catalyzed by CoY zeolite is reported. The salient features of this atom-economical, cost-effective, and high-yield cobalt-catalyzed protocol are aerobic conditions, lower reaction time, and milder reaction conditions without additives.
Duncan J Wardrop et al.
Organic letters, 14(6), 1548-1551 (2012-03-01)
The development of a mild, base-free method for the generation of alkylidenecarbenes is reported. Treatment of 5-hydroxyalkyl-1H-tetrazoles with carbodiimides generates products arising from the 1,2-rearrangement or [1,5]-C-H bond insertion of a putative alkylidenecarbene. Formation of this divalent intermediate is proposed
Luca Vaghi et al.
Gels (Basel, Switzerland), 7(3) (2021-08-28)
Gelatin is a costless polypeptide material of natural origin, able to form hydrogels that are potentially useful in biomaterial scaffold design for drug delivery, cell cultures, and tissue engineering. However, gelatin hydrogels are unstable at physiological conditions, losing their features
Hossein Naeimi et al.
Ultrasonics sonochemistry, 27, 408-415 (2015-07-19)
Ultrasound irradiation was applied for the appropriate and rapid synthesis of 1-substituted tetrazoles through cyclization reaction of various primary amines, sodium azide and triethyl orthoformate. This reaction was effectively catalyzed by ZnS nanoparticles as an efficient, recoverable and reusable catalyst.
Gopalakrishnan Aridoss et al.
The Journal of organic chemistry, 77(8), 4152-4155 (2012-04-07)
A series of 1-aryl/alkyl-1H-1,2,3,4-tetrazoles, 5-substituted 1H-tetrazoles, and 1,5- and 2,5-disubstituted 1H-tetrazoles were studied by a combination of experimental NMR (natural abundance (15)N, (15)N/(1)H HMBC, and (13)C) and computational GIAO-NMR techniques to explore substituent effects on (15)N (and (13)C) NMR chemical
Patrick Hochegger et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 15(4), 409-416 (2018-10-17)
Human African Trypanosomiasis (HAT, sleeping sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone to resistance and require parenteral administration. Malaria is responsible
Jian-Guo Zhang et al.
Journal of molecular modeling, 15(1), 67-77 (2008-10-23)
The tautomerism and intramolecular hydrogen shifts of 5-amino-tetrazole in the gas phase were studied in the present work. The minimum energy path (MEP) information of 5-amino-tetrazole was obtained at the CCSD(T)/6-311G**//MP2/6-311G** level of theory. The six possible tautomers of 1H
Rafie H Abu-Eittah et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 316-328 (2012-10-06)
Azido-tetrazole equilibrium is sensitive to: substitution, solvent, temperature and phase. In this work, the effects of the type and position of substitution on the thiazole ring of azidothiazoles on its structural parameters and on the azido-tetrazole equilibrium have been theoretically
Satsuki Otsuki et al.
Bioorganic & medicinal chemistry letters, 23(6), 1608-1611 (2013-02-19)
Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily accepted nucleophilic attack of thiol
Scott P Webster et al.
Bioorganic & medicinal chemistry letters, 20(11), 3265-3271 (2010-05-11)
Inhibitors of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11beta-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11beta-HSD1 over 11beta-HSD2
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-acyltetrazoles from azides and acyl cyanides.
Zachary P Demko et al.
Angewandte Chemie (International ed. in English), 41(12), 2113-2116 (2002-06-17)
Nieves R Paz et al.
Organic letters, 14(13), 3388-3391 (2012-06-15)
The fragmentation of anomeric alkoxyl radicals (ARF) and the subsequent intramolecular cyclization promoted by hypervalent iodine reagents provide an excellent method for the synthesis of tetrazolo-sugars. This new reaction offers additional advantages for the synthesis of these compounds, including the
Michael Limbach
Chemistry & biodiversity, 3(2), 119-133 (2006-12-29)
Catalytic enantioselective methodology has dramatically been enriched by the re-discovery of the simple amino acid proline as a chiral catalyst in the year 2000. Although no catalyst offers such a simple and broad access to quite complex reaction products, as
Marco Worch et al.
Carbohydrate research, 343(12), 2118-2129 (2007-12-08)
An unexpected and interesting intramolecular side reaction occurred during the attempted synthesis of glycosyl cyanides upon treatment of 1-O-acetyl-3-azido-3-deoxyallose derivatives with TMSCN and different Lewis acids. Exo-1,2-O-cyanoalkylidene derivatives formed by neighboring group participation and attack of cyanide underwent, after Lewis-acid
Jessica L Durham et al.
Inorganic chemistry, 51(14), 7825-7836 (2012-07-07)
The preparation of two new families of hexanuclear rhenium cluster complexes containing benzonitrile and phenyl-substituted tetrazolate ligands is described. Specifically, we report the preparation of a series of cluster complexes with the formula [Re(6)Se(8)(PEt(3))(5)L](2+) where L = benzonitrile, p-aminobenzonitrile, p-methoxybenzonitrile
Danny Burg et al.
Bioorganic & medicinal chemistry letters, 12(12), 1579-1582 (2002-06-01)
Glutathione (GSH) conjugates inhibit enzymes that are involved in drug metabolism and drug resistance, but their cellular uptake is very low. To improve membrane-permeability, we synthesized a novel GSH-conjugate analogue with a tetrazole carboxylate isostere at the glycine position. Introduction
Olga I Shmatova et al.
The Journal of organic chemistry, 78(18), 9214-9222 (2013-08-16)
A new route to tetrazole-derived cyclic amines based on the TMSN3-modified Ugi reaction with 2-substituted cyclic imines was elaborated. The reaction allows the direct preparation of five-, six-, and seven-membered cyclic amines substituted with a tetrazole ring, which are important
Annamaria Halasz et al.
Chemosphere, 241, 125008-125008 (2019-10-12)
Tetrazoles have wide industrial applications, notably in the pharmaceutical industry. Tetrazole derivatives such as bis(1H-tetrazol-5-yl)amine (H2BTA) have recently been considered by the defense industry as high nitrogen composite propellants. Photodegradation studies under solar simulating conditions showed that H2BTA was partially
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