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Qing Song Hu et al.
Biomedical and environmental sciences : BES, 28(4), 253-262 (2015-05-15)
This study was aimed to investigate the effects of carbon monoxide releasing molecule (CORM-2), a novel carbon monoxide carrier, on the reendothelialization of carotid artery in rat endothelial denudation model. Male rats subjected to carotid artery balloon injury were treated
Charlotte Stentoft et al.
Journal of chromatography. A, 1356, 197-210 (2014-07-16)
Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved understanding of the absorption and intermediary metabolism of PP is essential.
Jan Tkadlec et al.
Microbial drug resistance (Larchmont, N.Y.), 21(4), 416-423 (2015-04-01)
Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus
V Samuel Raj et al.
Antimicrobial agents and chemotherapy, 58(8), 4283-4289 (2014-02-20)
We present here the novel ketolide RBx 14255, a semisynthetic macrolide derivative obtained by the derivatization of clarithromycin, for its in vitro and in vivo activities against sensitive and macrolide-resistant Streptococcus pneumoniae. RBx 14255 showed excellent in vitro activity against
Juozas Nainys et al.
BMC biotechnology, 14, 100-100 (2014-12-10)
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a
Dai Q Trinh et al.
The Journal of general virology, 96(Pt 5), 1086-1097 (2015-01-09)
Three (MoCAV/F2, MoCAV/F8 and MoCAV/F11) of four mouse mAbs established against the A2/76 strain of chicken anemia virus (CAV) showed neutralization activity. Immunoprecipitation showed a band at ~50 kDa in A2/76-infected cell lysates by neutralizing mAbs, corresponding to the 50
Florian Weinberger et al.
Biochemical and biophysical research communications, 456(1), 294-297 (2014-12-03)
Islet-1 positive (Islet-1(+)) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta
Qing Liu et al.
Vascular pharmacology, 67-69, 59-66 (2015-04-15)
Vascular smooth muscle cells (VSMCs) play a crucial role in atherosclerotic lesion formation. Sparstolonin B (SsnB) is a TLR2/TLR4 antagonist that inhibits inflammatory responses in multiple cell types. Herein, we investigated if SsnB inhibited VSMC proliferation, migration, inflammatory response and
Vincenzo Cuccurullo et al.
Current radiopharmaceuticals, 6(1), 41-47 (2013-03-09)
The skeleton is one of the preferential sites for metastases of solid tumors, and metastatic disease is the most common malignancy of the bone. Diagnosis and evaluation of skeletal metastases require more frequently a combined approach of different diagnostic methods.
Nan Li et al.
Molecular medicine reports, 12(2), 3177-3183 (2015-05-09)
Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may
Diogo R M Moreira et al.
Journal of enzyme inhibition and medicinal chemistry, 30(4), 615-621 (2014-11-29)
This study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally related to the naturally-occurring lapachol and lapachone. Of the compounds tested, 3-(3-methylbut-1-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate (1) was the most active against Plasmodium falciparum among both natural
Ashraf S Al-Madhoun et al.
Mini reviews in medicinal chemistry, 4(4), 341-350 (2004-05-12)
Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1
Thomas H King et al.
PloS one, 9(7), e101904-e101904 (2014-07-23)
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based
Junichi Hoshino et al.
Journal of nanoscience and nanotechnology, 13(7), 4593-4600 (2013-08-02)
Thymidine derivatives with carboxylic acid and pyridyl groups were synthesized for constructing one-dimensional network structure based on hydrogen bonding in crystalline state. The solid sate structures and hydrogen bonding networks of the thymidine derivatives were characterized by single X-ray diffraction
Ending vertical transmission of hepatitis B: the third trimester intervention.
Monika Sarkar et al.
Hepatology (Baltimore, Md.), 60(2), 448-451 (2014-03-29)
Dominique Muschter et al.
Arthritis research & therapy, 17, 169-169 (2015-06-25)
Numerous observations indicate that rheumatoid arthritis (RA) has a bone marrow component. In parallel, local synovial changes depend on neuronal components of the peripheral sympathetic nervous system. Here, we wanted to analyze whether collagen II-induced arthritis (CIA) has an impact
Xiaolong Zhuo et al.
The Journal of cell biology, 210(5), 727-735 (2015-09-02)
During the G2 to M phase transition, a portion of mitotic regulator Plk1 localizes to the kinetochores and regulates the initiation of kinetochore-microtubule attachments for proper chromosome alignment. Once kinetochore-microtubule attachment is achieved, this portion of Plk1 is removed from
Jian Sun et al.
Hepatology (Baltimore, Md.), 59(4), 1283-1292 (2014-01-03)
An optimization strategy based on the Roadmap concept is supposed to improve the clinical outcomes of patients with suboptimal antiviral response. The aim of this study was to prove the concept with a multicenter, open-label, randomized, controlled study. In all
Maja Mustapic et al.
Human molecular genetics, 23(23), 6375-6384 (2014-07-06)
Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are only incompletely
Justus Reunanen et al.
Applied and environmental microbiology, 81(11), 3655-3662 (2015-03-22)
Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals. A. muciniphila has been linked with intestinal health and improved metabolic status in obese and type 2 diabetic subjects. Specifically, A. muciniphila has
Eivind Valen Egeland et al.
Clinical & experimental metastasis, 32(8), 755-767 (2015-09-10)
S100A4 promotes metastasis in several types of cancer, but the involved molecular mechanisms are still incompletely described. The protein is associated with a wide variety of biological functions and it locates to different subcellular compartments, including nuclei, cytoplasm and extracellular
Lucia Natarelli et al.
PloS one, 10(11), e0142421-e0142421 (2015-11-07)
Epidemiological studies suggest that moderate and prolonged consumption of coffee is associated with a reduced risk of developing type 2 diabetes but the molecular mechanisms underlying this effect are not known. In this study, we report the effects of physiological
Yunxin Liu et al.
Endocrine-related cancer, 21(4), 639-651 (2014-07-13)
Patients with ulcerative colitis are at a very high risk of developing colorectal cancer. Corticotrophin-releasing hormone (CRH) family peptides and their receptors (CRHRs) are found to modulate inflammation and tumor cell growth. However, the role of CRH family peptides and
Wei Chen et al.
Molecular medicine reports, 12(5), 7712-7720 (2015-10-16)
A previous nationwide Chinese epidemiological study revealed through isolation of A‑B+ Clostridium difficile strains, which produce toxin B (TcdB), but not toxin A TcdA, that the strains are widespread and more frequent in east Asian countries,. The development of a
Su Zhang et al.
Current protocols in nucleic acid chemistry, Chapter 4, Unit 4-Unit 4 (2013-03-21)
This unit describes the chemical synthesis of α-L-threofuranosyl nucleic acid (TNA) triphosphates for thymidine (T), guanosine (G), cytidine (C), and the diaminopurine (D) analog of adenosine and their incorporation into TNA oligonucleotides by enzyme-mediated polymerization of a DNA primer-template complex.
Formation of thymidine, cyclic deoxyguanosine and cyclic deoxycytidine adducts of the mutagen 2-bromoacrolein and their role in mutagenicity and clastogenicity.
J H Meerman et al.
IARC scientific publications, (125)(125), 449-452 (1994-01-01)
JungJin Lee et al.
Biochemical and biophysical research communications, 452(1), 42-47 (2014-08-19)
Protein phosphatase 4 (PP4) has been known to have critical functions in DNA double strand break (DSB) repair and cell cycle by the regulation of phosphorylation of its target proteins, such as H2AX, RPA2, KAP-1, 53BP1. However, it is largely
Saskia Willenbrock et al.
PloS one, 9(6), e98788-e98788 (2014-06-11)
The architectural transcription factor HMGA2 is abundantly expressed during embryonic development. In several malignant neoplasias including prostate cancer, high re-expression of HMGA2 is correlated with malignancy and poor prognosis. The let-7 miRNA family is described to regulate HMGA2 negatively. The
Raed Rizkallah et al.
Oncotarget, 6(3), 1446-1461 (2015-01-13)
TOPK/PBK is an oncogenic kinase upregulated in most human cancers and its high expression correlates with poor prognosis. TOPK is known to be activated by Cdk1 and needed for mitotic cell division; however, its mitotic functions are not yet fully
M Ailenberg et al.
British journal of pharmacology, 172(15), 3748-3763 (2015-04-09)
Dynasore has been used extensively as an inhibitor of clathrin-mediated endocytosis. While studying the role of endocytosis in LPS-induced signalling events, we discovered that dynasore itself induced activation of NF-κB, independently of its effects on endocytosis and without involving the
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