- A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau.
A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau.
Cerebral cortex (New York, N.Y. : 1991) (2015-05-23)
Lei Pei, Shan Wang, Huijuan Jin, Linlin Bi, Na Wei, Honglin Yan, Xin Yang, Chengye Yao, Mengmeng Xu, Shu Shu, Yu Guo, Huanhuan Yan, Jianhua Wu, Hao Li, Pei Pang, Tian Tian, Qing Tian, Ling-Qiang Zhu, You Shang, Youming Lu
PMID25995053
摘要
Synaptic spine loss is one of the major preceding consequences of stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death in a mouse model with stroke. We found that DAPK1 phosphorylates Tau protein at Ser262 (pS(262)) in cortical neurons of stroke mice. Either genetic deletion of DAPK1 kinase domain (KD) in mice (DAPK1-KD(-/-)) or blocking DAPK1-Tau interaction by systematic application of a membrane permeable peptide protects spine damages and improves neurological functions against stroke insults. Thus, disruption of DAPK1-Tau interaction is a promising strategy in clinical management of stroke.
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