- Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
Bioorganic & medicinal chemistry letters (2005-05-03)
Hong Yong, Yu Gui Gu, Richard F Clark, Thomas Marron, Zhenkun Ma, Niru Soni, Gregory G Stone, Angela M Nilius, Kennan Marsh, Stevan W Djuric
PMID15863336
摘要
A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.