- Inhibitors of the FEZ-1 metallo-beta-lactamase.
Inhibitors of the FEZ-1 metallo-beta-lactamase.
Bioorganic & medicinal chemistry letters (2006-12-13)
Benoît M R Liénard, Louise E Horsfall, Moreno Galleni, Jean-Marie Frère, Christopher J Schofield
PMID17157014
摘要
Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7microM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
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