- Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).
Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).
Bioorganic & medicinal chemistry letters (2006-12-08)
Abdelselam Ali, Marianne Bliese, Jo-Anne M Rasmussen, Roger M Sargent, Simon Saubern, David G Sawutz, John S Wilkie, David A Winkler, Kevin N Winzenberg, Ruth C J Woodgate
PMID17150358
摘要
A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.