- Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Bioorganic & medicinal chemistry (2009-06-23)
Hendra Gunosewoyo, Mark J Coster, Maxwell R Bennett, Michael Kassiou
PMID19540765
摘要
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.