Roles of peptidoglycan recognition protein (PGRP) in immunity and implications for novel anti-infective measures.

Peptidoglycan recognition protein (PGRP) is an important host innate immunity arm capable of peptidoglycan and allied bacteria recognition. PGRP belongs to host pattern recognition receptors (PRRs) responsible for pathogen associated molecular patterns recognition, such as lipopolysaccharide, lipoteichoic acid, PGN, and mannose. As an essential host PRR, PGRP is well conserved from insects to mammals. The distribution, structure, function, regulation of gene expression, and evolution of PGRP from insects and mammals were summarized to furnish insights into this important molecule family.