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Merck
CN
  • Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.

Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.

Chemical & pharmaceutical bulletin (1990-10-01)
M Yamazaki, S Itoh, J Saji, K Tanabe, H Nakahama, Y Orita
摘要

2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot and the horizontal asymptote. Curvature in this plot indicated the existence of 2 classes of binding. One class was at a specific site, probably at carbonic anhydrase. Chromatographic data seemed to support the possibility.

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Sigma-Aldrich
4-氨基-6-氯-1,3-苯二磺酰胺, 98%
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Supelco
苯并噻二嗪相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material
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100 mL
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¥401.84
4 x 25 mL
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¥472.26
800 mL
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¥2,010.54
20 L
请联系客服了解存货情况
¥27,647.10