The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions.

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions.

Chemical communications (Cambridge, England) (2011-03-25)

Elzbieta Sochacka, Karina Kraszewska, Marek Sochacki, Milena Sobczak, Magdalena Janicka, Barbara Nawrot

摘要

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H(2)O(2) to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results may explain the tRNA loss of biological function in oxidative stress conditions.

材料

产品编号

品牌

产品描述

T4509

Sigma-Aldrich

4-硫代尿苷, ≥98%