A simplified and efficient synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

A simplified and efficient synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

Investigational new drugs (1996-01-01)

E C Taylor, R Chaudhari, K Lee

摘要

A new and extremely efficient synthesis of DDATHF from 4-vinylbenzoic acid and bromomalondialdehyde as precursors has been developed which proceeds in 48% overall yield.

材料

货号

品牌

产品描述

535079

Sigma-Aldrich

溴代丙二醛, 97%

232548

Sigma-Aldrich

3-乙氧基异丁烯醛, 96%