- Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2013-06-13)
J Gueudry, D Boutolleau, M Gueudin, S Burrel, A Miri, B Bodaghi, M Muraine
PMID23756055
摘要
Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein.