[Time-related effect of betapressin+ in patients with essential hypertension stage II].

Time-related effect of betapressin (penbutolol) has been studied in 24 patients with essential hypertension stage II. The drug was given in the morning, afternoon and evening in a dose 40 mg. Control group consisted of 20 patients with essential hypertension stage II on betapressin at a mean daily dose 108.4 +/- 6.25 mg. Pre- and posttreatment hemodynamic parameters were registered at tetrapolar chest rheography. Arterial pressure was measured according to N.S. Korotkov. In the study group the parameters were taken 6 times a day each 4 hours before and after the treatment course. The course lasted for 20 days on the average in both groups. The study discovered time-related effect of betapressin; negative chronotropic effect in the morning and evening, negative inotropic effect in the day time. The hypotensive effect varied with the day hour being the highest in the single administration.