CN

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

摘要

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

材料

货号

品牌

产品描述

Sigma-Aldrich

钴, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

Raney^®-镍, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

Sigma-Aldrich

镍, wire, diam. 0.25 mm, ≥99.9%

Sigma-Aldrich

钴, granular, 99.99% trace metals basis

Sigma-Aldrich

镍, powder, <1 μm, 99.8% trace metals basis

Sigma-Aldrich

钴, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Sigma-Aldrich

钴, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

钴, pieces, 99.5% trace metals basis

Sigma-Aldrich

镍, foil, thickness 0.25 mm, 99.995% trace metals basis

Sigma-Aldrich

镍, wire, diam. 0.5 mm, ≥99.99% trace metals basis

Sigma-Aldrich

镍, wire, diam. 0.5 mm, ≥99.9% trace metals basis

镍, pellets, 100g, max. size 10mm, 99.999%

Sigma-Aldrich

镍, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

钴, foil, thickness 1.0 mm, 99.95% trace metals basis

镍, foil, 100x100mm, thickness 0.25mm, annealed, 99%

Sigma-Aldrich

钴, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

镍, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis

镍, pellets, 20g, max. size 5mm, 99.99+%

镍, foil, 100x100mm, thickness 0.1mm, annealed, 99%

镍, foil, 100x100mm, thickness 1.0mm, annealed, 99.98%

镍, rod, 100mm, diameter 1.5mm, 99.99+%

镍, mesh, 130x130mm, nominal aperture 0.34mm, thickness 0.025mm, wire diameter 0.041mm, 70 wires/inch, open area 80%, electro-formed mesh, 99.9%

镍, foil, 100x100mm, thickness 1.6mm, 99%

镍, sphere, 100pcs, diameter 3.0mm, precision sphere grade 200, 99%

镍, foil, light tested, 25x25mm, thickness 0.0125mm, 99.99+%

镍, foil, 2m coil, thickness 0.025mm, coil width 600mm, as rolled, 99%

钴, foil, 100x100mm, thickness 0.25mm, as rolled, 99.9%

镍, pellets, 100g, max. size 10mm, 99.99+%

Sigma-Aldrich

钴, rod, diam. 5.0 mm, 99.95% trace metals basis

镍, foil, not light tested, 25x25mm, thickness 0.001mm, 99.95%