Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Anticancer research (2015-01-01)

Maurizio Pompili, Nicoletta De Matthaeis, Antonio Saviano, Ilario De Sio, Giampiero Francica, Franco Brunello, Alessandro Cantamessa, Antonio Giorgio, Umberto Scognamiglio, Fabio Fornari, Francesco Giangregorio, Fabio Piscaglia, Silvia Gualandi, Eugenio Caturelli, Paola Roselli, Laura Riccardi, Gian Ludovico Rapaccini

PMID25550567

摘要

The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm. Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis. The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group. PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

材料

产品编号

品牌

产品描述

E7023

Sigma-Aldrich

乙醇，Pure 200纯度, Molecular Biology

459844

Sigma-Aldrich

纯乙醇, 200 proof, ACS reagent, ≥99.5%

459828

Sigma-Aldrich

纯乙醇, 200 proof

493546

Sigma-Aldrich

纯乙醇, 200 proof, meets USP testing specifications

459836

Sigma-Aldrich

纯乙醇, 200 proof, anhydrous, ≥99.5%

E7148

Sigma-Aldrich

乙醇，Pure 190纯度, for molecular biology

493511

Sigma-Aldrich

纯乙醇, 190 proof, ACS spectrophotometric grade, 95.0%

51976

Sigma-Aldrich

酒精, BioUltra, Molecular Biology, ≥99.8%, (absolute alcohol, without additive, A15 o¹)

270741

Sigma-Aldrich

酒精试剂, denatured, suitable for HPLC

362808

Sigma-Aldrich

酒精试剂, reagent grade

PHR1070

Supelco

无水乙醇, Pharmaceutical Secondary Standard; Certified Reference Material

493538

Sigma-Aldrich

纯乙醇, 190 proof, meets USP testing specifications

187380

Sigma-Aldrich

乙醇，变性, denatured, reagent grade

02483

Supelco

酒精, standard for GC

02857

Sigma-Aldrich

酒精, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL¹, ~96% (based on denaturant-free substance)

E-029

Supelco

乙醇-50标准液 CRM, 50 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-033

Supelco

乙醇-300标准液 CRM, 300 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

277649

Sigma-Aldrich

酒精试剂, anhydrous, ≤0.003% water

E-040

Supelco

乙醇-10标准液 CRM, 10 mg/dL in H₂O, pack of 10 × 1.2 mL ampules, certified reference material, Cerilliant^®

E-030

Supelco

乙醇-80 标准液 CRM, 80 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-031

Supelco

乙醇-100（10支/盒)标准液 CRM, 100 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

32221

Sigma-Aldrich

酒精, puriss. p.a., absolute, ≥99.8% (GC)

676829

Sigma-Aldrich

酒精试剂, anhydrous, ≤0.005% water

48075

Supelco

Ethanol 溶液, certified reference material, 2000 μg/mL in methanol

29221

Sigma-Aldrich

酒精, tested according to Ph. Eur.

E-053

Supelco

乙醇-500标准液 CRM, 500 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E2385

Supelco

10% (v/v) 乙醇标准品, 10 % (v/v) in H₂O, analytical standard

E-041

Supelco

乙醇-150, 150 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-032

Supelco

乙醇-200 (10支/盒)标准液 CRM, 200 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-036

Supelco

乙醇-400（10支/盒)标准液 CRM, 400 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®