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Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity.

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity.

Marine drugs (2015-10-17)

Shogo Mori, Howard Williams, Davey Cagle, Kristopher Karanovich, F David Horgen, Roger Smith, Coran M H Watanabe

摘要

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

材料

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产品描述

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甲醇, ACS reagent, ≥99.8%

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二甲基亚砜-d ₆, 99.9 atom % D

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甲醇-d₄, ≥99.8 atom % D

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乙腈, ACS reagent, ≥99.5%

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二氯甲烷, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

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Triton^™ X-100, laboratory grade

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甲醇-d₄, ≥99.8 atom % D

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