- Subchronic administration of ascorbic acid elicits antidepressant-like effect and modulates cell survival signaling pathways in mice.
Subchronic administration of ascorbic acid elicits antidepressant-like effect and modulates cell survival signaling pathways in mice.
The Journal of nutritional biochemistry (2016-10-11)
Morgana Moretti, Josiane Budni, Camille Mertins Ribeiro, Débora Kurrle Rieger, Rodrigo Bainy Leal, Ana Lúcia S Rodrigues
PMID27721116
摘要
In this study, we examined the ability of subchronic ascorbic acid administration to produce an antidepressant-like effect in the mouse tail suspension test (TST). Moreover, we investigated the effect of this vitamin on hippocampal and cerebrocortical brain-derived neurotrophic factor (BDNF) immunocontent, phosphorylation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK), p38