- Nano-precipitated curcumin loaded particles: effect of carrier size and drug complexation with (2-hydroxypropyl)-β-cyclodextrin on their biological performances.
Nano-precipitated curcumin loaded particles: effect of carrier size and drug complexation with (2-hydroxypropyl)-β-cyclodextrin on their biological performances.
International journal of pharmaceutics (2017-01-29)
Carla Serri, Mario Argirò, Linda Piras, Damiano Gustavo Mita, Antonina Saija, Luigi Mita, Maurizio Forte, Simona Giarra, Marco Biondi, Stefania Crispi, Laura Mayol
PMID28130197
摘要
In this work, curcumin (CURC)-encapsulating nanoparticles (NPs), made up of an amphiphilic blend of poloxamers and PLGA (PPC NPs) at different polymer concentrations, were prepared by nanoprecipitation. CURC was preliminarily complexed with (2-hydroxypropyl)-β-cyclodextrin (HPβCD) to improve its loading efficiency. The formation of host-guest complexes of CURC with HPβCD (CD-CURC) was confirmed by means of
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