- Phosphatidylinositol 4,5-bisphosphate (PIP
Phosphatidylinositol 4,5-bisphosphate (PIP
The Journal of physiology (2017-04-07)
Matthew K Kirchner, Robert C Foehring, Lie Wang, Giri Kumar Chandaka, Joseph C Callaway, William E Armstrong
PMID28383826
摘要
Afterhyperpolarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular neurons regulate repetitive firing and spike frequency adaptation but relatively little is known about PIP Oxytocin (OT)- and vasopressin (VP)-secreting magnocellular neurons of the supraoptic nucleus (SON) display calcium-dependent afterhyperpolarizations (AHPs) following a train of action potentials that are critical to shaping the firing patterns of these cells. Previous work demonstrated that the lipid phosphatidylinositol 4,5-bisphosphate (PIP