pH-Responsive Aerobic Nanoparticles for Effective Photodynamic Therapy.

Photodynamic therapy (PDT), an O To overcome this obstacle, a stimuli-responsive drug delivery system with O The nanoparticles exhibited high stability in aqueous medium and efficient cellular uptake by tumor cells facilitating their accumulation in tumors by enhanced permeability and retention (EPR) effect. In acidic environment, irradiation caused disassembly of the nanoparticles resulting in the quick release of Catalase and the photosensitizer with continuous formation of cytotoxic singlet oxygen ( Due to the unique O