- Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia.
Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia.
Frontiers in cellular neuroscience (2018-01-10)
Zhi-Hang Lin, Si-Yuan Wang, Li-Li Chen, Jia-Yuan Zhuang, Qing-Feng Ke, Dan-Rui Xiao, Wen-Ping Lin
PMID29311826
摘要
The spinal cord injury (SCI) is a detrimental neurological disease involving the primary mechanical injury and secondary inflammatory damage. Curtailing the detrimental neuroinflammation would be beneficial for spinal cord function recovery. Microglia reside in the spinal cord and actively participate in the onset, progression and perhaps resolution of post-SCI neuroinflammation. In the current study, we tested the effects of methylene blue on microglia both
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