Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.

Frontiers in molecular neuroscience (2016-12-10)

Jenna M Ramaker, Robert S Cargill, Tracy L Swanson, Hanil Quirindongo, Marlène Cassar, Doris Kretzschmar, Philip F Copenhaver

PMID27932950

摘要

Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family of transmembrane glycoproteins expressed by all higher organisms, including two mammalian orthologs (APLP1 and APLP2) that have complicated investigations into the specific activities of APP. By comparison, insects express only a single APP-related protein (APP-Like, or APPL) that contains the same protein interaction domains identified in APP. However, unlike its mammalian orthologs, APPL is only expressed by neurons, greatly simplifying an analysis of its functions

材料

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产品描述

A2228

Sigma-Aldrich

单克隆抗 β-肌动蛋白抗体小鼠抗, clone AC-74, purified immunoglobulin, buffered aqueous solution

A8717

Sigma-Aldrich

抗淀粉样肽前体蛋白C-末端兔抗, IgG fraction of antiserum, buffered aqueous solution

565770

Sigma-Aldrich

γ-分泌酶抑制剂IIX, Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM).

565788

Sigma-Aldrich

β-分泌酶抑制剂 IV, β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1).

171601

Sigma-Aldrich

淀粉样肽前体蛋白 β-分泌酶抑制剂, The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

SAB4300464

Sigma-Aldrich

Anti-APP (Ab-668) antibody produced in rabbit, affinity isolated antibody