Q2128
使君子氨酸
L-glutamate agonist, powder
别名:
β-(3,5-二氧代-1,2,4-氧杂重氮烷-2-基)-L-丙氨酸
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关于此项目
经验公式（希尔记法）:
C5H7N3O5
化学文摘社编号:
分子量:
189.13
Beilstein:
1078734
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.32
产品名称
使君子氨酸, powder
表单
powder
质量水平
颜色
white to off-white
溶解性
ethanol: <0.17 mg/mL
H2O: 0.5 mg/mL
0.1 M HCl: 1.4 mg/mL
1 M NH4OH: 20 mg/mL
organic solvents: insoluble
储存温度
2-8°C
SMILES字符串
N[C@@H](CN1OC(=O)NC1=O)C(O)=O
InChI
1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChI key
ASNFTDCKZKHJSW-REOHCLBHSA-N
基因信息
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一般描述
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.
应用
Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.
Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.
生化/生理作用
Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Sujeenthar Tharmalingam et al.
Neuropharmacology, 63(4), 667-674 (2012-06-02)
The metabotropic glutamate receptors (mGluRs) are evolutionarily conserved from nematodes to vertebrates. The Caenorhabditis elegans (C. elegans) genome contains three mGluR genes referred to as mgl-1, mgl-2, and mgl-3. The aim of this study was to characterize the pharmacological profiles
Optical recordings of Ca2+ signaling activities from identified inner ear cells in cochlear slices and hemicochleae
Xi Lin
Brain Res. Protoc., 11(2) (2003)
Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null
Pablo J Giraudi et al.
PloS one, 6(12), e29078-e29078 (2012-01-05)
We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine∶glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes). In this study we demonstrate that
Víctor Fernández-Dueñas et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-02)
In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than the orthosteric binding sites and can modulate agonist-mediated activation. Interestingly, allosteric regulation may allow a fine-tuned
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