Q2128
使君子氨酸
L-glutamate agonist, powder
别名:
β-(3,5-二氧代-1,2,4-氧杂重氮烷-2-基)-L-丙氨酸
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关于此项目
经验公式（希尔记法）:
C5H7N3O5
化学文摘社编号:
分子量:
189.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
1078734
产品名称
使君子氨酸, powder
InChI
1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
SMILES string
N[C@@H](CN1OC(=O)NC1=O)C(O)=O
InChI key
ASNFTDCKZKHJSW-REOHCLBHSA-N
form
powder
color
white to off-white
solubility
ethanol: <0.17 mg/mL, H2O: 0.5 mg/mL, 0.1 M HCl: 1.4 mg/mL, 1 M NH4OH: 20 mg/mL, organic solvents: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
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相关类别
General description
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.
Application
Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.
Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.
Biochem/physiol Actions
Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Xi Lin
Brain Res. Protoc., 11(2) (2003)
Sujeenthar Tharmalingam et al.
Neuropharmacology, 63(4), 667-674 (2012-06-02)
The metabotropic glutamate receptors (mGluRs) are evolutionarily conserved from nematodes to vertebrates. The Caenorhabditis elegans (C. elegans) genome contains three mGluR genes referred to as mgl-1, mgl-2, and mgl-3. The aim of this study was to characterize the pharmacological profiles
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Plotegher N, et al.
Cell Death and Differentiation, 27(5), 1588-1603 (2020)
Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null
Pablo J Giraudi et al.
PloS one, 6(12), e29078-e29078 (2012-01-05)
We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine∶glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes). In this study we demonstrate that
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