HPA010080
抗-COL6A3 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
抗胶原α-3（VI）链前体 兔抗
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:20-1:50
immunogen sequence
PRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQCDWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVT
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL6A3(1293)
General description
COL6A3（VI a3型胶原）是称为胶原的纤维化细胞外基质蛋白的a亚基。在肌肉中，它是表达最丰富的胶原之一。该基因位于人染色体2q37上。
Immunogen
胶原α-3（VI）链前体重组蛋白表位信号标签（PrEST）
Application
兔产生的抗COL6A3抗体，属于Prestige 抗体，由人类蛋白质图谱（HPA）项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。
Biochem/physiol Actions
在啮齿动物中的研究表明，瘦素治疗会负调控COL6A3（VIα 3型胶原）的表达。它在人脂肪组织中的表达也受瘦素的调节，在肥胖时其表达降低。在人类中，它的表达与BMI（体质指数）和脂肪量有关。COL6A3在肥胖和T2DM（2型糖尿病）患者中的表达相似，并且它调节脂肪组织巨噬细胞趋化和炎症。它的表达也与重量增加有关。这种蛋白在脂肪细胞中的表达与胰岛素抵抗有关，后者被认为依赖于PPAR（过氧化物酶体增殖物激活受体）α介导的脂肪细胞发育。
该基因的突变与乌尔里希型先天性肌营养不良的轻度和重度形式有关。该基因的突变也与Bethlem肌病有关，这是一种常染色体显性遗传疾病。
该基因的突变与乌尔里希型先天性肌营养不良的轻度和重度形式有关。该基因的突变也与Bethlem肌病有关，这是一种常染色体显性遗传疾病。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。
每种Prestige 抗体的检测方法如下：
每种Prestige 抗体的检测方法如下：
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
Physical form
磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠
Other Notes
相应抗原APREST86862
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Laura J McCulloch et al.
Endocrinology, 156(1), 134-146 (2014-10-23)
Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability, and contributes to metabolic dysfunction. Collagen type VI, α3 (COL6A3) encodes 1 subunit of a fibrotic extracellular matrix protein highly expressed in rodent AT. Knockout of collagen VI in
Rocío N Villar-Quiles et al.
Journal of neuromuscular diseases, 8(4), 633-645 (2021-03-23)
Dominant and recessive autosomal pathogenic variants in the three major genes (COL6A1-A2-A3) encoding the extracellular matrix protein collagen VI underlie a group of myopathies ranging from early-onset severe conditions (Ullrich congenital muscular dystrophy) to milder forms maintaining independent ambulation (Bethlem
Andrei Turtoi et al.
Journal of proteome research, 13(12), 5660-5669 (2014-10-18)
Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. Success stories evidenced by the use of antibody-drug conjugates in other tumor types are encouraging, but targets specific to glioblastoma and accessible through the bloodstream remain scarce.
Bartosz Wojtas et al.
Cancers, 11(3) (2019-03-02)
Gliosarcoma is a very rare brain tumor reported to be a variant of glioblastoma (GBM), IDH-wildtype. While differences in molecular and histological features between gliosarcoma and GBM were reported, detailed information on the genetic background of this tumor is lacking.
Zhou Fang et al.
Frontiers in cellular neuroscience, 15, 816781-816781 (2022-01-11)
Collagen VI (COL6) in the microenvironment was recently identified as an extracellular signal that bears the function of promoting orderly axon bundle formation. However, the large molecular weight of COL6 (≈2,000 kDa) limits its production and clinical application. It remains
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