HPA011222
抗-GALNT2 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
抗-GalNAc-T2, 抗-UDP-GalNAc：多肽N-乙酰半乳糖胺基转移酶2, 抗-pp-GaNTase 2, 抗-多肽GalNAc转移酶2, 抗-多肽N-乙酰半乳糖胺基转移酶2, 抗-蛋白UDP乙酰半乳糖胺基转移酶2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200
immunogen sequence
SCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GALNT2(2590)
General description
GALNT2（多肽N-乙酰氨基半乳糖转移酶2）属于ppGalNAc-T家族，是一种II型跨膜蛋白。催化结构域位于高尔基体腔区，R型凝集素结构域位于C端。该基因位于人类染色体1q41-q42。
Immunogen
多肽N-乙酰半乳糖胺基转移酶2
Application
兔产生的抗GALNT2 抗体，属 Prestige 抗体，由 人类蛋白质图谱（HPA）项目 开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。该抗体还已通过免疫荧光 和蛋白质印迹测试。想要查看有关Prestige Antibodies和HPA的 方案 和其他实用信息，请访问 sigma.com/prestige。
Biochem/physiol Actions
GALNT2（多肽N-乙酰氨基半乳糖基转移酶2）催化蛋白质O-连接糖基化的第一步。它负责将第一个N-乙酰半乳糖胺（GalNAc）单糖附着到蛋白质上。该基因在癌症中表达上调，可能与肿瘤发生有关。它抑制基质金属蛋白酶（MMP）-2和转化生长因子（TGF）-β1的表达，从而抑制胃癌细胞的增殖和转移。它通过调节绒毛外滋养层（EVT）侵袭来调节胎盘发育。GALNT2还通过调节ENPP1（外核苷酸焦磷酸酶）的表达参与胰岛素稳态，ENPP1是胰岛素受体信号传导的抑制剂。它在2型糖尿病患者中的表达减少，因此，它可能在高血糖中发挥作用。它在口腔鳞状细胞癌（OSCC）中表达上调，并通过调节O-糖基化和EGFR（表皮生长因子受体）活性来增强OSCC的侵袭性。
Features and Benefits
Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。
每个Prestige Antibody都是按照以下方法进行测试的：
每个Prestige Antibody都是按照以下方法进行测试的：
- 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
- 364个人类重组蛋白片段的蛋白阵列。
Physical form
溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠
Other Notes
对应抗原APREST72034
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
常规特殊物品
低风险生物材料
此项目有
Mei-Chun Lin et al.
Oral oncology, 50(5), 478-484 (2014-03-04)
Oral squamous cell carcinoma (OSCC) is one of the leading cancers worldwide. Aberrant glycosylation affects many cellular properties in cancers, including OSCC. This study aimed to explore the role of N-acetylgalactosaminyltransferase 2 (GALNT2) in OSCC. Immunohistochemistry was performed to study
Wan-Ling Ho et al.
Oncotarget, 5(23), 12247-12259 (2014-11-05)
Aberrant expression of the simple mucin-type carbohydrate antigens such as Tn antigen is associated with malignant transformation and cancer progression. N-acetylgalactosaminyltransferase 2 (GALNT2), one of the enzymes that mediate the initial step of mucin-type O-glycosylation, is responsible for forming Tn
Antonella Marucci et al.
PloS one, 8(7), e70159-e70159 (2013-07-31)
Impaired insulin action plays a major role in the pathogenesis of type 2 diabetes, a chronic metabolic disorder which imposes a tremendous burden to morbidity and mortality worldwide. Unraveling the molecular mechanisms underlying insulin resistance would improve setting up preventive
Dong Hua et al.
International journal of molecular medicine, 30(6), 1267-1274 (2012-09-21)
Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which catalyzes initiation of mucin-type O-glycosylation, is also involved in
Iris A García et al.
Journal of cell science, 130(24), 4155-4167 (2017-11-03)
Many secretory cells increase the synthesis and secretion of cargo proteins in response to specific stimuli. How cells couple increased cargo load with a coordinate rise in secretory capacity to ensure efficient transport is not well understood. We used thyroid
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