HPA044682
Anti-PLIN4 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-KIAA1881, Anti-S3-12, Anti-perilipin 4
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:2500-1:5000, western blot: 0.04-0.4 μg/mL
immunogen sequence
GVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGT
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLIN4(729359)
General description
Perilipin 4 (PLIN4) is a lipid droplet protein, encoded by the gene mapped to human chromosome 19q13.3-13.4. PLIN4 is highly expressed in white adipose tissue and is also expressed at low levels in heart and skeletal muscle. The encoded protein and PLIN5 exhibit distinct though overlapping tissue expression pattern.
Immunogen
perilipin 4 recombinant protein epitope signature tag (PrEST)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Perilipin 4 (PLIN4) might be involved in the formation of lipid droplets (LDs) in adipocytes. Perilipins play a vital role in regulation of lipid turnover. In mice, knockdown of this gene downregulates Plin5 expression and decreases cardiac lipid accumulation. Mutation in the gene is linked to development of gastric cancer. In addition, variation in the gene might also lead to obesity.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Other Notes
Corresponding Antigen APREST82778
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
Richardson K
PLoS ONE, 6 (2011)
Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.
Zhang J
Scientific Reports (2015)
Perilipin 4 in human skeletal muscle: localization and effect of physical activity.
Pourteymour S
Physiological Reports, 3 (2015)
Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice.
Chen W
American Journal of Physiology. Endocrinology and Metabolism, 304(7) (2013)
Shirin Pourteymour et al.
Physiological reports, 3(8), doi:10-doi:10 (2015-08-13)
Perilipins (PLINs) coat the surface of lipid droplets and are important for the regulation of lipid turnover. Knowledge about the physiological role of the individual PLINs in skeletal muscle is limited although lipid metabolism is very important for muscle contraction.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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