Skip to Content
Merck
CN
All Photos(2)

Key Documents

SAB3500566

Sigma-Aldrich

Anti-TCF12 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HEB, Anti-HTF4, Anti-bHLHb20

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

AAH50556

UniProt accession no.

Q99081

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TCF12(6938)

General description

Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3.

Immunogen

TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12.

Application

Anti-TCF12 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500566.

Physical form

Supplied in PBS with 0.02% sodium azide.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
59991004

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service