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Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil","externalUrl":false,"widths":[],"title":"LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18","uuid":"82ec29e6-e74e-4886-8cb8-1a05ee797339","link":"","caption":"","captionTitle":"Figure 1.","displayPopupTitle":false,":type":"cms-commons/components/content/image"},"table":{"anchorId":null,"enableSort":false,"verticalTable":false,"headline":"Conditions","title":null,"caption":null,"table":"\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n

Sample/Matrix	Sample spiked into rat plasma
SPE Well Plate	HybridSPE®-PLus 96-Well Plate (575659-U)
Condition	100 uL of spiked rat plasma was added to the HybridSPE plate well, followed by 300 uL of protein precipitation solvent, acetonitrile with 1% formic acid. (The plate, sealed, secured on a vibrater, agitated by vibration at 1000 rpm for 2 min. The plate was transfered to a vacuum manifold. Vacuum was applied at 10 in Hg for 4 min.)
Column	Titan C18, 5 cm x 2.1 mm I.D., 1.9 µm particles (577122-U)
Column Temp.	35 °C
Mobile Phase	[A] Water; [B] methanol, both with 0.1% formic acid/10 mM ammonium formate
Gradient	0-1 min, 45%B; 1.5-4 min 90%B, 4.5-8 min 45%B
Flow Rate	0.2 mL/min
Pressure	2900 psi
Injection	1 µL
Detector	MS, ESI(+), MRM mode

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Analysis Note	Sample pretreatment: Sample spiked into rat plasma \r\n \r\nDetector: \r\nMRM transitions: \r\nPeak MRM \r\n1. Quinidine 325.2/81.1, 307.1 \r\n2. Verapamil 455.3/165.1 \r\n3. Digoxin 798.5/651.5 \r\n4. Amiodarone 646.1/58.1, 100.1
Categories	Analytical Chromatography, Clinical, SPE Applications, cardiac drugs, Antihypertensives, antihypertensives, Cardiac Drugs, Cardiac drugs
Featured Industry	Clinical
Legal Information	HybridSPE is a registered trademark of Sigma-Aldrich Co. LLC, Titan is a trademark of Sigma-Aldrich Co. LLC
Suitability	Application for LC-MS

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