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SML3000

Sigma-Aldrich

Ripasudil Hydrochloride

≥98% (HPLC), rho-associated protein kinase (ROCK) inhibitor, powder

Synonym(s):

4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride, K-115 hydrochloride

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5 MG
CN¥1,128.87
25 MG
CN¥4,550.09

About This Item

Empirical Formula (Hill Notation):
C15H18FN3O2S · xHCl
CAS Number:
223645-67-8
Molecular Weight:
323.39 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,128.87

Estimated to ship onNovember 04, 2025Details

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Product Name

Ripasudil Hydrochloride, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1c2c(cnc1)cccc2[S](=O)(=O)N3[C@H](CNCCC3)C

InChI

1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1

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GSK334429 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0500

GSK334429 hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 5 mg/mL, clear (warmed)

solubility

H2O: 5 mg/mL (clear solution)

Biochem/physiol Actions

A potent and selective rho-associated protein kinase (ROCK) inhibitor with in vivo intraocular pressure (IOP) reducing efficacy.
Ripasudil (K-115) is a more potent and selective rho-associated protein kinase (ROCK) inhibitor (IC50 = 51 nM/ROCK1, 19 nM/ROCK2, 2.1 μM/PKACα, 27 μM/PKC, and 0.37 μM/CaMKII?) than Y-27632 and HA-1077 (Fasudil). Ripasudil demonstrates in vivo efficacy in reducing intraocular pressure (IOP) by stimulating aqueous humour drainage through the trabecular meshwork.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000413552
    0000413553
    0000413553
    0000413552
    0000313905

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    Seigo Nakabayashi et al.
    Experimental eye research, 139, 132-135 (2015-07-22)
    Ripasudil (K-115) is a novel Rho kinase inhibitor with a potent intraocular pressure-lowering effect. However, it is unclear whether ripasudil affects the retinal blood flow (RBF). We investigated the effect of ripasudil on feline retinal microcirculation. Ripasudil (5 μM, 50 μM or
    Karly P Garnock-Jones
    Drugs, 74(18), 2211-2215 (2014-11-22)
    Ripasudil hydrochloride hydrate (Glanatec® ophthalmic solution 0.4 %; hereafter referred to as ripasudil) is a small-molecule, Rho-associated kinase inhibitor developed by Kowa Company, Ltd. for the treatment of glaucoma and ocular hypertension. This compound, which was originally discovered by D.
    Akiko Futakuchi et al.
    Experimental eye research, 149, 107-115 (2016-07-11)
    The most common cause of glaucoma surgery failure is scar formation induced by activation of wound-healing responses and resultant fibrosis at the surgical site. We investigated the effects of ripasudil, a Rho kinase inhibitor, on activation of human conjunctival fibroblasts
    Tomoyuki Isobe et al.
    Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 579-590 (2015-12-19)
    1. We examined the metabolism of ripasudil (K-115), a selective and potent Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, by in vitro and in vivo studies. 2. First, we identified metabolites and metabolic enzymes involved in ripasudil metabolism. Species differences were observed
    Yoshio Kaneko et al.
    Scientific reports, 6, 19640-19640 (2016-01-20)
    Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, was the first ophthalmic solution developed for the treatment of glaucoma and ocular hypertension in Japan. Topical administration of K-115 decreased intraocular pressure (IOP) and increased outflow
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