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SML3000

Sigma-Aldrich

Ripasudil Hydrochloride

≥98% (HPLC)

Synonym(s):

4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride, K-115 hydrochloride

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10 L
CN¥16,781.63
50 L
CN¥72,703.07

CN¥16,781.63


Estimated to ship onAugust 14, 2025Details


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10 L
CN¥16,781.63
50 L
CN¥72,703.07

About This Item

Empirical Formula (Hill Notation):
C15H18FN3O2S · xHCl
CAS Number:
Molecular Weight:
323.39 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥16,781.63


Estimated to ship onAugust 14, 2025Details


Request a Bulk Order
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Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1c2c(cnc1)cccc2[S](=O)(=O)N3[C@H](CNCCC3)C

InChI

1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1

InChI key

QSKQVZWVLOIIEV-NSHDSACASA-N

Biochem/physiol Actions

A potent and selective rho-associated protein kinase (ROCK) inhibitor with in vivo intraocular pressure (IOP) reducing efficacy.
Ripasudil (K-115) is a more potent and selective rho-associated protein kinase (ROCK) inhibitor (IC50 = 51 nM/ROCK1, 19 nM/ROCK2, 2.1 μM/PKACα, 27 μM/PKC, and 0.37 μM/CaMKII?) than Y-27632 and HA-1077 (Fasudil). Ripasudil demonstrates in vivo efficacy in reducing intraocular pressure (IOP) by stimulating aqueous humour drainage through the trabecular meshwork.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

动植物来源培养基

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